US5710177A
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Synergistic combinations of active substance for the cosmetic or dermatological care of the skin, hair & nails
Assignee: Beiersdorf AG
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Filing: 1993-12-07
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Granted: 1998-01-20
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Expires: 2013-12-07
Abstract
Abstract PCT No. PCT/DE93/01166 Sec. 371 Date Aug. 11, 1995 Sec. 102(e) Date Aug. 11, 1995 PCT Filed Dec. 7, 1993 PCT Pub. No. WO94/14412 PCT Pub. Date Jul. 7, 1994Cosmetic and/or dermatological active compound combinations comprising a) an active amount of biotin and/or biotin esters, b) an active amount of one or more alpha -hydroxycarboxylic acids of the formula R'(R'')(OH)C COOHand/or an active amount of one or more alpha -ketocarboxylic acids of the formula R'C(O) COOHor their physiologically acceptable salts or esters wherein R' and R'' represent H-; branched or unbranched C1-25-alkyl- or C1-25-alkyl-substituted by one or more carboxyl groups and/or hydroxyl groups and/or a aldehyde groups and/or oxo groups (keto groups); phenyl- or phenyl substituted by one or more carboxyl groups and/or hydroxyl groups and/or branched and/or unbranched C1-25-alkyl groups; or wherein the alpha -carbon atom of the alpha -hydroxycarboxylic acid, together with R' and R'', forms a cycloalkyl group having 3 to 7 ring atoms or the cycloalkyl substituted by one or more carboxyl groups and/or hydroxyl groups and/or oxo groups (keto groups) and/or branched and/or unbranched C1-25-alkyl groups; and c) an active amount of one or more antioxidants.
Inventors
- 👤 Gerhard Sauermann
- 👤 Uwe Schonrock
- 👤 Volker Schreiner
- 👤 Franz Stab
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:52
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/67; A61K8/33; A61K8/36; A61K8/365; A61P; A61P17/00; A61P29/00; A61P43/00; A61Q; A61Q19/00; A61Q19/08; A61Q3/00; A61Q5/00; A61K2800/00; A61K2800/40; A61K2800/59; A61Q19/007
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
229 words
Cosmetic and/or dermatologically active compound combinations comprising a) an active amount of biotin and/or biotin esters, b) an active amount of one or more α-hydroxycarboxylic acids of the general formula ##STR12## and/or an active amount of one or more α-keto-carboxylic acids of the general formula ##STR13## wherein R' and R" independently of one another are chosen from the group consisting of (b1) H--, (b2) branched or unbranched C 1-25 -alkyl-, (b3) branched or unbranched C 1-25 -alkyl- which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or aldehyde groups and/or oxo groups (keto groups), (b4) phenyl- and (b5) phenyl- which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or branched and/or unbranched C 1-25 -alkyl groups, or wherein the α-carbon atom of the α-hydroxycarboxylic acid, together with R' and R", forms a (b6) unsubstituted cycloalkyl group having 3 to 7 ring atoms or a (b7) cycloalkyl group having 3 to 7 ring atoms which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or oxo groups (keto groups) and/or branched and/or unbranched C 1-25 -alkyl groups, and where the α-hydroxycarboxylic acid or the α-hydroxycarboxylic acids or the α-keto-carboxylic acid or the α-keto-carboxylic acids can optionally be present in the form of their physiologically tolerated salts and/or ethyl esters and/or methyl esters, and c) an active amount of one or more antioxidants.
Claim 2
Dependent Claim
229 words
Cosmetic and/or dermatologically active compound combinations comprising a) an active amount of biotin and/or biotin esters, b) an active amount of one or more α-hydroxycarboxylic acids of the general formula ##STR12## and/or an active amount of one or more α-keto-carboxylic acids of the general formula ##STR13## wherein R' and R" independently of one another are chosen from the group consisting of (b1) H--, (b2) branched or unbranched C 1-25 -alkyl-, (b3) branched or unbranched C 1-25 -alkyl- which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or aldehyde groups and/or oxo groups (keto groups), (b4) phenyl- and (b5) phenyl- which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or branched and/or unbranched C 1-25 -alkyl groups, or wherein the α-carbon atom of the α-hydroxycarboxylic acid, together with R' and R", forms a (b6) unsubstituted cycloalkyl group having 3 to 7 ring atoms or a (b7) cycloalkyl group having 3 to 7 ring atoms which is substituted by one or more carboxyl groups and/or hydroxyl groups and/or oxo groups (keto groups) and/or branched and/or unbranched C 1-25 -alkyl groups, and where the α-hydroxycarboxylic acid or the α-hydroxycarboxylic acids or the α-keto-carboxylic acid or the α-keto-carboxylic acids can optionally be present in the form of their physiologically tolerated salts and/or ethyl esters and/or methyl esters, and c) an active amount of one or more antioxidants.
Claim 3
Dependent Claim
36 words
Active compound combinations according to claim 1, wherein the weight ratio of biotin and/or esters thereof to the α-hydroxycarboxylic acid or acids and/or the α-keto-carboxylic acid or acids is in the range from 1:500 to 20:1.
Claim 4
Dependent Claim
34 words
Active compound combinations according to claim 1, wherein the biotin esters are compounds of the structure: ##STR14## wherein R is H, branched or unbranched C 1-18 -alkyl- or branched or unbranched C 1-18 -alkenyl-.
Claim 5
Dependent Claim
39 words
Active compound combinations according to claim 1, wherein the α-hydroxy acids are chosen from the group consisting of (b2) α-hydroxy-fatty acids, (b3) α-hydroxy-sugar acids or aliphatic α-hydroxy-fruit acids, (b4) unsubstituted aromatic α-hydroxycarboxylic acids and (b5) substituted aromatic α-hydroxycarboxylic acids.
Claim 6
Dependent Claim
72 words
Active compound combinations according to claim 4, wherein the α-hydroxy acids are chosen from the group consisting of (b2) α-hydroxycarboxylic acids according to the formula ##STR15## α-hydroxy-isocarboxylic acids according to the formula ##STR16## α-hydroxy-anteisocarboxylic acids according to the formula ##STR17## wherein n in each case is a number from 7 to 31, and (b3) aldonic acids, aldaric acids, uronic acids, glyceric acid, malic acid, lactic acid, hydroxy acetic acid and citric acid.
Claim 7
Dependent Claim
64 words
Active compound combinations according to claim 1, wherein the antioxidants are chosen from the group consisting of ascorbic acid, ascorbic acid derivatives, tocopherols, tocopheryl esters and other tocopherol derivatives, folic acid, phytic acid, ubiquinones, bile extract, cis-urocanic acid, trans-urocanic acid, carnosine, histidine, flavones, flavonoids, cysteine, cysteine, cysteine derivatives, tyrosine, carotenes and lycopene (psi-carotene), α-liponic acid, glutathione, glutathione esters, zinc oxide and zinc salts. salts.
Claim 8
Dependent Claim
17 words
Cosmetic and/or dermatological formulations comprising an active amount of an active compound combination according to claim 1.
Claim 9
Dependent Claim
47 words
Cosmetic and/or dermatological formulations according to claim 7, wherein the active amount ranges from 0.001-0.20% by weight of biotin and/or biotin esters, 0.001-5.00% by weight of one or more α-hydroxy-carboxylic acids and/or one or more α-keto-carboxylic acids and 0.001-10.00% by weight of an antioxidant or several antioxidants.
Claim 10
Dependent Claim
84 words
Process for the preparation of the cosmetic or dermatological formulations according to claim 7, wherein the biotin and/or biotin esters, preferably in an amount corresponding to 0.001-0.20% by weight, one or more α-hydroxycarboxylic acids and/or one or more α-keto-carboxylic acids in an amount corresponding to 0.001-5.0% by weight, and an antioxidant or several antioxidants in an amount corresponding to 0.001-5.00% by weight, in each case based on the total weight of the formulations, are incorporated into cosmetic or dermatological formulations in a known manner.
Claim 11
Dependent Claim
30 words
A method of caring for at least one of the skin and an integumentary appendages which comprises applying thereto an amount effective therefor of a combination according to claim 1.
Claim 12
Dependent Claim
24 words
A method of improving the appearance of dry skin which comprises applying thereto an amount effective therefor of a combination according to claim 1.
Claim 13
Dependent Claim
24 words
A method of improving the appearance of aged skin which comprises applying thereto an amount effective therefor of a combination according to claim 1.
Claim 14
Dependent Claim
32 words
A method of stimulating the endogenous capacity for the synthesis of skin fats or biochemical precursors thereof which comprises applying thereto an amount effective therefor of a combination according to claim 1.
Claim 15
Dependent Claim
34 words
A method of treating the skin of a patient with the manifestation of a topic dermatitis or seborrhoeic eczema which comprises applying thereto an amount effective therefor of a combination according to claim 1.
Claim 16
Dependent Claim
12 words
Active compounds according to claim 6, wherein the cysteine derivative is N-acetylcysteine.
Claim 17
Dependent Claim
11 words
Active compounds according to claim 6, wherein the carotene is β-carotene.
References Cited (Backward Citations)
EP0383467A2
Cited
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