US5707986A
Expired / Lapsed
US
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Angiographic method using green porphyrins in primate eyes
Assignee: Massachusetts Eye and Ear Infirmary
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Filing: 1994-03-14
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Granted: 1998-01-13
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Expires: 2014-03-14
Abstract
Abstract An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.
Inventors
- 👤 Joan W. Miller
- 👤 Lucy H.Y. Young
- 👤 Evangelos S. Gragoudas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1275; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/409; A61K31/555; A61K41/00; A61K41/0057; A61K41/0071; A61K49/00; A61K49/001; A61K49/0013; A61K49/0017; A61K49/0019; A61K49/0021; A61K49/0036; A61K49/0063; A61K49/0069; A61K49/0076; A61K49/0084; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
126 words
An angiographic method to observe the condition of blood vessels, including neovasculature in the eye of an intact living primate, which method comprises: a. administering to said primate comprising at least one eye for which said observation is desired and containing said neovasculature an amount of green porphyrin which will provide an observable amount of green porphyrin in the blood vessels and neovasculature of said eye; b. permitting sufficient time to elapse so that an observable amount of said green porphyrin resides in the blood vessels and neovasculature of the eye; and c. applying light of a wavelength in the range of about 550-700 nm to the eye so as to effect fluorescence of the green porphyrin; and d. detecting said fluorescence with a suitable camera.
Claim 2
Dependent Claim
126 words
An angiographic method to observe the condition of blood vessels, including neovasculature in the eye of an intact living primate, which method comprises: a. administering to said primate comprising at least one eye for which said observation is desired and containing said neovasculature an amount of green porphyrin which will provide an observable amount of green porphyrin in the blood vessels and neovasculature of said eye; b. permitting sufficient time to elapse so that an observable amount of said green porphyrin resides in the blood vessels and neovasculature of the eye; and c. applying light of a wavelength in the range of about 550-700 nm to the eye so as to effect fluorescence of the green porphyrin; and d. detecting said fluorescence with a suitable camera.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said green porphyrin is a BPD.
Claim 4
Dependent Claim
10 words
The method of claim 2 wherein said BPD is BPD-MA.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein said green porphyrin is complexed with low-density lipoprotein.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein said green porphyrin is contained in a liposomal preparation.
Claim 7
Dependent Claim
14 words
The method of claim 3 wherein said BPD-MA is contained in a liposomal preparation.
References Cited (Backward Citations)
US5171749A
Cited
US5214036A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |