US5707332A
Expired / Lapsed
US
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Apparatus and method to reduce restenosis after arterial intervention
Assignee: Columbia University
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Filing: 1995-11-30
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Granted: 1998-01-13
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Expires: 2015-11-30
Abstract
Abstract An apparatus guided by a guidewire within a patient's artery for reducing restenosis after arterial intervention in the patient's artery. A radiation dose delivery wire with a radiation source encapsulated within its distal end is inserted into a blind lumen in a balloon catheter to deliver radiation to a target area of the patient's artery.
Inventors
- 👤 Judah Z. Weinberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:16
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002; A61B; A61B17/00; A61B17/22; A61B2017/22051; A61B2017/22065; A61B2017/22068; A61M; A61M25/00; A61M25/10; A61M2025/1043; A61M2025/1047; A61M2025/1081; A61N5/1007; A61N2005/1008; A61N2005/1019; A61N2005/1021; A61N2005/1092; A61N2005/1094
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
106 words
An apparatus for reducing restenosis after arterial intervention in a patient's artery comprising: a balloon catheter with a fluid delivery port connected thereto; and a radioactive fluid inserted into the balloon catheter through the fluid delivery port, said radioactive fluid being selected from the group consisting of non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay.
Claim 2
Independent Claim
106 words
An apparatus for reducing restenosis after arterial intervention in a patient's artery comprising: a balloon catheter with a fluid delivery port connected thereto; and a radioactive fluid inserted into the balloon catheter through the fluid delivery port, said radioactive fluid being selected from the group consisting of non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay.
Claim 3
Dependent Claim
127 words
The apparatus of claim 1, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are selected from the group consisting of NA-24, SI-31, K-42, SC-43, SC-44, CO-55, MN-56, CU-61, NI-65, GA-66, GA-68, ZN-71, GA-72, AS-72, SE-73, BR-75, AS-76, BR-76, GE-77, KR-77, AS-78, Y-85, KR-87, ZR-87, NB-89, Y-90, NB-90, SR-91, Y-92, Y-93, ZR-97, IN-110, AG-112, AG-113, SB-122, SN-127, TE-129, BA-139, LA-140, LA-141, LA-142, PR-142, PR-145, TB-148, PM-150, EU-152, HO-166, RE-188, RE-190, IR-194, BI-212, and radioactive sodium-chloride.
Claim 4
Dependent Claim
72 words
The apparatus of claim 2, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are dissolved in an aqueous fluid.
Claim 5
Dependent Claim
70 words
The apparatus of claim 2, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are in gas phase.
Claim 6
Independent Claim
111 words
A method for reducing restenosis after arterial intervention in a patient's artery comprising: inserting a balloon catheter with a fluid delivery port connected thereto into the patient's artery; providing a radioactive fluid selected from the group consisting of non-iodine and nonphosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 KeV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay; and inserting the radioactive fluid into the balloon catheter through the fluid delivery port.
Claim 7
Independent Claim
111 words
A method for reducing restenosis after arterial intervention in a patient's artery comprising: inserting a balloon catheter with a fluid delivery port connected thereto into the patient's artery; providing a radioactive fluid selected from the group consisting of non-iodine and nonphosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 KeV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay; and inserting the radioactive fluid into the balloon catheter through the fluid delivery port.
Claim 8
Dependent Claim
127 words
The method of claim 5, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are selected from the group consisting of NA-24, SI-31, K-42, SC-43, SC-44, CO-55, MN-56, CU-61, NI-65, GA-66, GA-68, ZN-71, GA-72, AS-72, SE-73, BR-75, AS-76, BR-76, GE-77, KR-77, AS-78, Y-85, KR-87, ZR-87, NB-89, Y-90, NB-90, SR-91, Y-92, Y-93, ZR-97, IN-110, AG-112, AG-113, SB-122, SN-127, TE-129, BA-139, LA-140, LA-141, LA-142, PR-142, PR-145, TB-148, PM-150, EU-152, HO-166, RE-188, RE-190, IR-194, BI-212, and radioactive sodium-chloride.
Claim 9
Dependent Claim
72 words
The method of claim 6, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are dissolved in an aqueous fluid.
Claim 10
Dependent Claim
70 words
The method of claim 6, wherein said non-iodine and non-phosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 keV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay, are in gas phase.
Claim 11
Independent Claim
111 words
A method for reducing restenosis after arterial intervention in a patient's artery comprising: inserting a balloon catheter with a fluid delivery port connected thereto into the patient's artery; and selecting a radioactive fluid from the group consisting of non-iodine and nonphosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 KeV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay; and inserting the radioactive fluid into the balloon catheter through the fluid delivery port.
Claim 12
Independent Claim
111 words
A method for reducing restenosis after arterial intervention in a patient's artery comprising: inserting a balloon catheter with a fluid delivery port connected thereto into the patient's artery; and selecting a radioactive fluid from the group consisting of non-iodine and nonphosphorus based radioisotopes that decay with emission of beta plus or beta minus radiation, that have a half-life of between approximately 1 and 72 hours, that have an average decay energy of approximately 500-2000 KeV, and that have radiation intensity of greater than or equal to approximately 50%, said radiation intensity being measured in % per decay; and inserting the radioactive fluid into the balloon catheter through the fluid delivery port.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |