US5702823A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible coated article
Assignee: Cobe Cardiovascular Inc
•
Filing: 1996-10-10
•
Granted: 1997-12-30
•
Expires: 2016-10-10
Abstract
Abstract The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.
Inventors
- 👤 Lloyd Forrestal
- 👤 Marc Voorhees
- 👤 Yung-Ming Chen
- 👤 Richard A. Edrich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:47
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L31/00; A61L31/08; A61L31/10; A61L33/00; A61L33/06; A61L33/068; C; C09; C09D; C09D183/00; C09D183/10; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978; Y10T428/24998; Y10T428/249987; Y10T428/249991; Y10T428/249992; Y10T428/31504; Y10T428/31652; Y10T428/31663; Y10T428/31667; Y10T428/31678; Y10T428/31681; Y10T428/31786; Y10T428/31797
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
38 words
A metallic article having a base metal and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.02 to 0.35.
Claim 2
Dependent Claim
38 words
A metallic article having a base metal and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.02 to 0.35.
Claim 3
Dependent Claim
19 words
A metallic article according to claim 1 wherein the X-ray fluorescence intensity ratio is the range 0.05 to 0.25.
Claim 4
Dependent Claim
20 words
A metallic article according to claim 1 wherein the X-ray fluorescence intensity ratio is in the range 0.09 to 0.18.
Claim 5
Dependent Claim
19 words
A metallic article according to claim 1 wherein said article is a flat-sheet heat exchanger or a membrane compartment.
Claim 6
Dependent Claim
13 words
A metallic article according to claim 4 wherein said article is stainless steel.
Claim 7
Dependent Claim
13 words
A metallic article according to claim 5 wherein said stainless steel is 316L.
Claim 8
Dependent Claim
15 words
A metallic article according to claim 1 wherein the triblock copolymer is a polycaprolactone-polysiloxane-polycaprolactone copolymer.
Claim 9
Dependent Claim
42 words
A metallic article according to claim 7 wherein the triblock copolymer comprises polycaprolactone blocks having each a nominal molecular weight in the range 1000 to 10,000 and a polysiloxane block having a nominal molecular weight in the range of 1000 to 5000.
Claim 10
Dependent Claim
37 words
A metallic article according to claim 8 wherein the triblock copolymer comprises polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range of 2000 to 3000.
Claim 11
Dependent Claim
24 words
A metallic article according to claim 1 wherein the biocompatible coating is subjected to ionizing radiation to produce an insoluble and tenaciously adhering coating.
Claim 12
Independent Claim
69 words
A method of coating a metallic article with a polylactone-polysiloxane-polylactone triblock copolymer comprising the steps of contacting the article with a solution of the copolymer in a solvent capable of wetting the article, the solution having a specified concentration of the copolymer, said concentration imparting to the article, after drying, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 13
Independent Claim
69 words
A method of coating a metallic article with a polylactone-polysiloxane-polylactone triblock copolymer comprising the steps of contacting the article with a solution of the copolymer in a solvent capable of wetting the article, the solution having a specified concentration of the copolymer, said concentration imparting to the article, after drying, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 14
Dependent Claim
15 words
A method according to claim 11 wherein the metallic article is a stainless steel article.
Claim 15
Dependent Claim
20 words
A method according to claim 11 wherein the X-ray fluorescence relative intensity is in the range of 0.09 to 0.18.
Claim 16
Dependent Claim
43 words
A method according to claim 11 wherein the triablock copolymer has polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range of 2000 to 3000 and the solvent is methyl ethyl ketone.
Claim 17
Dependent Claim
32 words
A method according to claim 11 comprising the additional step of subjecting the article having a surface coating of the copolymer to ionizing radiation to produce an insoluble and tenaciously adhering coating.
Claim 18
Dependent Claim
21 words
A method according to claim 15 wherein the ionizing radiation is in the form of x-rays, γ-rays or an electron beam.
Claim 19
Dependent Claim
20 words
A method according to claim 15 wherein the radiation is x-rays in the dose range of 0.35 to 13.0 Mrad.
Claim 20
Independent Claim
70 words
A method of coating a metallic article with a polylactone-polysiloxane-polylactone triblock copolymer comprising contacting said article with a solution of the copolymer in a solvent capable of wetting the article, the solution having a specified concentration of the copolymer, said concentration being such that, after drying, the article has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range of 0.05 to 0.25.
Claim 21
Independent Claim
70 words
A method of coating a metallic article with a polylactone-polysiloxane-polylactone triblock copolymer comprising contacting said article with a solution of the copolymer in a solvent capable of wetting the article, the solution having a specified concentration of the copolymer, said concentration being such that, after drying, the article has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range of 0.05 to 0.25.
Claim 22
Dependent Claim
15 words
A method according to claim 18 wherein the metallic article is a stainless steel article.
Claim 23
Dependent Claim
20 words
A method according to claim 19 wherein the X-ray fluorescence relative intensity is in the range of 0.09 to 0.18.
Claim 24
Dependent Claim
43 words
A method according to claim 18 wherein the triblock copolymer has polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range of 2000 to 3000 and the solvent is methyl ethyl ketone.
Claim 25
Dependent Claim
32 words
A method according to claim 18 comprising the additional step of subjecting the article having a surface coating of the copolymer to ionizing radiation to produce an insoluble and tenaciously adhering coating.
Claim 26
Dependent Claim
21 words
A method according to claim 22 wherein the ionizing radiation is in the form of x-rays, γ-rays or an electron beam.
Claim 27
Dependent Claim
20 words
A method according to claim 22 wherein the radiation is x-rays in the dose range of 0.25 to 13.0 Mrad.
References Cited (Backward Citations)
US3651616A
Cited
DE1944969A1
Cited
US4675361A
Cited
US4636552A
Cited
US4663413A
Cited
US4872867A
Cited
US4970765A
Cited
US4929510A
Cited
US5179142A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-12-29 | 2001-06-30 | 2001-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-12-29 | 2005-06-30 | 2005-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-12-29 | 2009-06-30 | 2009-12-30 | $7700.00 | Window Closed / Lapsed |