US5683710A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Percutaneous absorption preparation
Assignee: Toa Eiyo Ltd
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Filing: 1995-09-13
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Granted: 1997-11-04
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Expires: 2015-09-13
Abstract
Abstract A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.
Inventors
- 👤 Hitoshi Akemi
- 👤 Takateru Muraoka
- 👤 Kazuhiro Higashio
- 👤 Saburo Otsuka
- 👤 Takashi Kinoshita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:33
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
189 words
A percutaneous absorption preparation comprising a backing and a pressure-sensitive adhesive layer containing a drug for percutaneous absorption formed on one side of the backing, wherein the pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester comprising a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms, a monoglyceride comprising a higher fatty acid having 8 to 10 carbon atoms and glycerol, wherein the weight ratio of said fatty acid ester to said monoglyceride is from 1:0.05 to 1:0.25, wherein the higher fatty acid is selected from the group consisting of caprylic acid, pelargonic acid and capric acid, and isosorbide dinitrate as the drug for percutaneous absorption, in an amount in the range of 2 to 50% by weight, and wherein the pressure-sensitive adhesive layer is crosslinked, wherein the total content of said fatty acid ester and monoglyceride is from 60 to 200 parts by weight per 100 parts by weight of said acrylic copolymer.
Claim 2
Dependent Claim
189 words
A percutaneous absorption preparation comprising a backing and a pressure-sensitive adhesive layer containing a drug for percutaneous absorption formed on one side of the backing, wherein the pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester comprising a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms, a monoglyceride comprising a higher fatty acid having 8 to 10 carbon atoms and glycerol, wherein the weight ratio of said fatty acid ester to said monoglyceride is from 1:0.05 to 1:0.25, wherein the higher fatty acid is selected from the group consisting of caprylic acid, pelargonic acid and capric acid, and isosorbide dinitrate as the drug for percutaneous absorption, in an amount in the range of 2 to 50% by weight, and wherein the pressure-sensitive adhesive layer is crosslinked, wherein the total content of said fatty acid ester and monoglyceride is from 60 to 200 parts by weight per 100 parts by weight of said acrylic copolymer.
Claim 3
Dependent Claim
40 words
The percutaneous absorption preparation as claimed in claim 1, wherein said backing is a porous film or a laminate of a porous film and a non-porous plastic film, and the pressure-sensitive adhesive layer is formed on the porous film side.
Claim 4
Dependent Claim
24 words
The percutaneous absorption preparation of claim 1, wherein the isosorbide dinitrate is in an amount in the range of 10 to 40% by weight.
Claim 5
Dependent Claim
26 words
The percutaneous absorption preparation of claim 1, wherein the total content of the fatty acid ester and monoglyceride is from 70 to 180 parts by weight.
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JPS57116011A
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DE3839410A1
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EP0436203A2
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JPH03223212A
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US5204109A
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EP0531938A1
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US5419912A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-03 | 2001-05-05 | 2001-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-03 | 2005-05-05 | 2005-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-03 | 2009-05-05 | 2009-11-04 | $7700.00 | Window Closed / Lapsed |