Therapeutic use of adenosine compounds as surgical anesthetics

Claim 1

A method of performing surgery on a mammal comprising the steps of: a) determining a baseline value of a physiologic parameter selected from the group consisting of respiratory rate, blood pressure, blood oxygen, blood carbon dioxide, and heart rate; b) monitoring the physiologic parameter to ascertain deviations from the baseline value; c) initiating administration of a pharmaceutical composition comprising a compound selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate; d) adjusting the rate at which the pharmaceutical composition is administered to said mammal so as to provide a level of said compound sufficient to produce at least two effects selected from the group consisting of sedation, analgesia, inhibition of stress, and skeletal muscle relaxation; e) initiating surgery; and f) adjusting the rate at which the pharmaceutical composition is administered to said mammal so as to provide a level of said compound sufficient to maintain said effects, wherein the rate can be adjusted to maintain the blood pressure within about 20% of a baseline value while maintaining said effects or, when said blood pressure differs from said baseline value by more than about 20%, the rate can be adjusted to return the blood pressure to within about 20% of the baseline value while maintaining said effects.

Claim 2

A method of performing surgery on a mammal comprising the steps of: a) determining a baseline value of a physiologic parameter selected from the group consisting of respiratory rate, blood pressure, blood oxygen, blood carbon dioxide, and heart rate; b) monitoring the physiologic parameter to ascertain deviations from the baseline value; c) initiating administration of a pharmaceutical composition comprising a compound selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate; d) adjusting the rate at which the pharmaceutical composition is administered to said mammal so as to provide a level of said compound sufficient to produce at least two effects selected from the group consisting of sedation, analgesia, inhibition of stress, and skeletal muscle relaxation; e) initiating surgery; and f) adjusting the rate at which the pharmaceutical composition is administered to said mammal so as to provide a level of said compound sufficient to maintain said effects, wherein the rate can be adjusted to maintain the blood pressure within about 20% of a baseline value while maintaining said effects or, when said blood pressure differs from said baseline value by more than about 20%, the rate can be adjusted to return the blood pressure to within about 20% of the baseline value while maintaining said effects.

Claim 13

A method of providing anesthesia to a mammal for surgery, comprising the step of: administering a pharmaceutical composition to said mammal at a rate sufficient to produce a level of anesthesia in said mammal sufficient to anesthetize said mammal for surgery while maintaining a physiologic parameter of said mammal within a desired range, wherein said pharmaceutical composition comprises an adenosine compound selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, and said physiologic parameter is selected from the group consisting of blood pressure, heart rate, respiratory rate, pH, and partial pressure of at least one blood gas.

Claim 14

A method of providing anesthesia to a mammal for surgery, comprising the step of: administering a pharmaceutical composition to said mammal at a rate sufficient to produce a level of anesthesia in said mammal sufficient to anesthetize said mammal for surgery while maintaining a physiologic parameter of said mammal within a desired range, wherein said pharmaceutical composition comprises an adenosine compound selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, and said physiologic parameter is selected from the group consisting of blood pressure, heart rate, respiratory rate, pH, and partial pressure of at least one blood gas.

Claim 19

A method of maintaining anesthesia in an anesthetized mammal, comprising the step of: administering to an anesthetized mammal a pharmaceutical composition at a rate sufficient to maintain a desired level of anesthesia in said mammal, wherein said pharmaceutical composition comprises an adenosine compound, wherein said adenosine compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, and said rate is sufficient to provide an anesthetically effective amount of said adenosine compound without inducing hypotension in said mammal, and wherein said desired level of anesthesia can be maintained and hypotension avoided in said mammal during surgical stimulation by adjustment of said rate of administration, and said desired level of anesthesia can be maintained despite dosage reduction of at least one compound other than an adenosine compound which would be required in the absence of said adenosine compound to maintain said desired level of anesthesia.

Claim 20

A method of maintaining anesthesia in an anesthetized mammal, comprising the step of: administering to an anesthetized mammal a pharmaceutical composition at a rate sufficient to maintain a desired level of anesthesia in said mammal, wherein said pharmaceutical composition comprises an adenosine compound, wherein said adenosine compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, and said rate is sufficient to provide an anesthetically effective amount of said adenosine compound without inducing hypotension in said mammal, and wherein said desired level of anesthesia can be maintained and hypotension avoided in said mammal during surgical stimulation by adjustment of said rate of administration, and said desired level of anesthesia can be maintained despite dosage reduction of at least one compound other than an adenosine compound which would be required in the absence of said adenosine compound to maintain said desired level of anesthesia.

Claim 23

A method of anesthetizing a mammal for surgery, comprising: a first step of administering a first anesthetic agent to said mammal; a second step of administering to said mammal as an anesthetic adjuvant a composition comprising an adenosine compound, wherein said adenosine compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate; and adjusting the rate of said administration of said adenosine compound in order to cause at least two effects selected from the group consisting of sedation, analgesia, inhibition of stress, and muscle relaxation, whereby said mammal is anesthetized sufficiently for surgery by said first and second steps, and said effects are maintained during surgery on said mammal.

Claim 24

A method of anesthetizing a mammal for surgery, comprising: a first step of administering a first anesthetic agent to said mammal; a second step of administering to said mammal as an anesthetic adjuvant a composition comprising an adenosine compound, wherein said adenosine compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate; and adjusting the rate of said administration of said adenosine compound in order to cause at least two effects selected from the group consisting of sedation, analgesia, inhibition of stress, and muscle relaxation, whereby said mammal is anesthetized sufficiently for surgery by said first and second steps, and said effects are maintained during surgery on said mammal.

Claim 26

A method of anesthetizing a mammal for surgery utilizing an adenosine compound, comprising the step of: administering to a mammal an anesthetically effective amount of a composition comprising an adenosine compound sufficient to anesthetize said mammal for surgery, wherein said compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate.

Claim 27

A method of anesthetizing a mammal for surgery utilizing an adenosine compound, comprising the step of: administering to a mammal an anesthetically effective amount of a composition comprising an adenosine compound sufficient to anesthetize said mammal for surgery, wherein said compound is selected from the group consisting of adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate.