US5630837A — Acoustic ablation

Claim 1

Independent Claim 140 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an array of acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for controlling one or more of said ablation transducers independently of other ones of said transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter, at least one of said acoustic transducers having an annular configuration designed for generating acoustic energy that radiates in a radial pattern surrounding the circumference of said catheter body.

Claim 2

Dependent Claim 140 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an array of acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for controlling one or more of said ablation transducers independently of other ones of said transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter, at least one of said acoustic transducers having an annular configuration designed for generating acoustic energy that radiates in a radial pattern surrounding the circumference of said catheter body.

Claim 3

Dependent Claim 20 words

The catheter system of claim 1, wherein each of said acoustic transducers is a full cylinder having said annular configuration.

Claim 4

Dependent Claim 28 words

The catheter system of claim 1, wherein each of said acoustic transducers is a half cylinder and wherein said transducers are arranged in pairs having said annular configuration.

Claim 5

Dependent Claim 14 words

The catheter system of claim 1, wherein said annular configuration comprises a full cylinder.

Claim 6

Dependent Claim 14 words

The catheter system of claim 1, wherein said controlling mechanism controls said transducers individually.

Claim 7

Dependent Claim 16 words

The catheter system of claim 1, wherein the array is a plurality of annular acoustic transducers.

Claim 8

Dependent Claim 12 words

The catheter system of claim 1, wherein the mechanism includes a controller.

Claim 9

Dependent Claim 29 words

The catheter system of claim 1, wherein the mechanism includes a series of switches, including a switch coupling one or more of said ablation transducers to the power source.

Claim 10

Dependent Claim 24 words

The catheter system of claim 1, wherein the mechanism includes a phase controller for selectively varying the phase of said power driving said transducers.

Claim 11

Dependent Claim 21 words

The catheter system of claim 9, wherein the mechanism further includes delay lines connecting the ablation transducers to said power source.

Claim 12

Dependent Claim 23 words

The catheter system of claim 1 wherein said mechanism includes a frequency control for varying the frequency of the power driving said transducers.

Claim 13

Dependent Claim 30 words

The catheter system of claim 1, further comprising: insulation, positioned between adjacent transducers of the array of acoustic ablation transducers, to electrically and acoustically insulate adjacent transducers from each other.

Claim 14

Dependent Claim 19 words

The catheter system of claim 1 wherein said ablation transducers are embedded in the wall of said catheter body.

Claim 15

Dependent Claim 32 words

The catheter system of claim 1 including a lumenal space in heat transfer communication with said transducer array for providing a passage for a flow of cooling fluid to cool said transducers.

Claim 16

Dependent Claim 21 words

The catheter system of claim 1, wherein adjacent ablation transducers are spaced by a distance of about 0.001 to 0.12 inches.

Claim 17

Dependent Claim 19 words

The catheter system of claim 1, wherein said transducers have a beam angle from about 22° to about 122°.

Claim 18

Dependent Claim 27 words

The catheter system of claim 1, wherein said transducers are constructed for generating acoustic energy at power levels in the range of about 1 to 102 db.

Claim 19

Dependent Claim 24 words

The catheter system of claim 1, further comprising: an array of matching layers corresponding to and coupled to the array of annular acoustic transducers.

Claim 20

Dependent Claim 41 words

The catheter system of claim 1 further comprising: an acoustic energy redirection device positioned in the vicinity of said acoustic ablation transducer array and configured for directing acoustic energy produced by said acoustic ablation transducer array toward tissue to be ablated.

Claim 21

Dependent Claim 21 words

The catheter system of claim 19, wherein said redirection device is a reflecting shield positioned about a portion of said array.

Claim 22

Dependent Claim 24 words

The catheter system of claim 20, further comprising: a rotation mechanism coupled to the catheter body for rotating the catheter body about its axis.

Claim 23

Dependent Claim 22 words

The catheter system of claim 1, further comprising: a sheath for surrounding the catheter body, a portion of the sheath being sonolucent.

Claim 24

Dependent Claim 70 words

The catheter system of claim 22, wherein the catheter body includes a catheter lumenal space in heat communication with said transducers and a fluid port in communication with said catheter lumenal space, said catheter body is disposed within said sheath and said sheath further includes a sheath lumenal space for circulating cooling fluid through the sheath lumenal space, the fluid port, and the catheter lumenal space to cool said transducers.

Claim 25

Dependent Claim 55 words

The catheter system of claim 22, wherein said catheter body is disposed within said sheath and said sheath further includes a lumenal space in heat communication with said transducers and an outlet port in communication with said lumenal space for circulating cooling fluid through the sheath and the outlet port to cool the ablation transducers.

Claim 26

Dependent Claim 30 words

The catheter system of claims 22, wherein said catheter body is disposed within said sheath and said sheath includes an end opening through which said catheter body can be extended.

Claim 27

Dependent Claim 15 words

The catheter system of claim 22, wherein the sheath further includes a sonolucent standoff balloon.

Claim 28

Dependent Claim 12 words

The catheter system of claim 1, further including an acoustic imaging transducer.

Claim 29

Dependent Claim 13 words

The catheter system of claim 1 further including a radio frequency ablation electrode.

Claim 30

Dependent Claim 10 words

The catheter system of claim 1 further including mapping electrodes.

Claim 31

Dependent Claim 175 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, a flexible sheath of extended length constructed for delivery to locations within a body of a living being and constructed to receive said catheter body, said sheath being at least partially sonolucent, a lumen within said catheter body, and a fluid port in communication with said lumen and said sheath, said fluid port being constructed to cause fluid to pass between said lumen and a space external to said catheter body and within said sheath, said lumen and said sheath being constructed to cause fluid to pass in a longitudinal direction relative to said catheter body and in the vicinity of said acoustic ablation device to cool said acoustic ablation device.

Claim 32

Dependent Claim 175 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, a flexible sheath of extended length constructed for delivery to locations within a body of a living being and constructed to receive said catheter body, said sheath being at least partially sonolucent, a lumen within said catheter body, and a fluid port in communication with said lumen and said sheath, said fluid port being constructed to cause fluid to pass between said lumen and a space external to said catheter body and within said sheath, said lumen and said sheath being constructed to cause fluid to pass in a longitudinal direction relative to said catheter body and in the vicinity of said acoustic ablation device to cool said acoustic ablation device.

Claim 33

Dependent Claim 20 words

The catheter system of claim 30, wherein said acoustic ablation device includes a radiating outer surface, and an inner surface.

Claim 34

Dependent Claim 20 words

The catheter system of claim 31, wherein said lumen causes fluid to pass in the vicinity of said inner surface.

Claim 35

Dependent Claim 18 words

The catheter system of claim 31, where said acoustic ablation device includes an array of annular acoustic transducers.

Claim 36

Dependent Claim 100 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a sonolucent standoff balloon for positioning said acoustic ablation device in proximity to tissue to be ablated, said acoustic ablation device being positioned to ablate said tissue by passage of acoustic energy through said balloon.

Claim 37

Dependent Claim 100 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a sonolucent standoff balloon for positioning said acoustic ablation device in proximity to tissue to be ablated, said acoustic ablation device being positioned to ablate said tissue by passage of acoustic energy through said balloon.

Claim 38

Dependent Claim 115 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and an acoustic energy redirection device positioned in the vicinity of said acoustic ablation device and constructed for redirecting a portion of acoustic energy produced by said acoustic ablation device in a direction of another portion of said acoustic energy produced by said acoustic ablation device toward tissue to be ablated.

Claim 39

Dependent Claim 115 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an acoustic ablation device constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and an acoustic energy redirection device positioned in the vicinity of said acoustic ablation device and constructed for redirecting a portion of acoustic energy produced by said acoustic ablation device in a direction of another portion of said acoustic energy produced by said acoustic ablation device toward tissue to be ablated.

Claim 40

Dependent Claim 24 words

The catheter system of claim 35, further comprising: a rotation mechanism coupled to the catheter body for rotating the catheter body about its axis.

Claim 41

Dependent Claim 152 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, a linear array of annular acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for selectively controlling one or more of said ablation transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter body, said mechanism including: a power applicator configured for providing power to one or more of said transducers, and a phase shifter configured for shifting the phase of said power provided to one or more of said transducers independently of other ones of said transducers.

Claim 42

Dependent Claim 152 words

A catheter system for tissue ablation, comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, a linear array of annular acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for selectively controlling one or more of said ablation transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter body, said mechanism including: a power applicator configured for providing power to one or more of said transducers, and a phase shifter configured for shifting the phase of said power provided to one or more of said transducers independently of other ones of said transducers.

Claim 43

Dependent Claim 23 words

The catheter system of claim 37, wherein said mechanism further includes a controller constructed to control said power applicator and said phase shifter.

Claim 44

Dependent Claim 30 words

The catheter system of claim 37, wherein said power applicator includes a series of switches, including a switch coupling one or more of said ablation transducers to the power source.

Claim 45

Dependent Claim 34 words

The catheter system of claim 37, wherein said phase shifter includes a phase controller for selectively varying the phase of said power provided to one or more of said transducers by said power applicator.

Claim 46

Dependent Claim 25 words

The catheter system of claim 40, wherein said phase shifter further includes delay lines connecting one or more of said transducers to said power source.

Claim 47

Dependent Claim 34 words

The catheter system of claim 37, wherein said mechanism further includes a frequency control device for varying the frequency of said power provided to one or more of said transducers by said power applicator.

Claim 48

Independent Claim 216 words

A method for selective acoustic ablation of tissue within the body of a living being, comprising providing a catheter system for acoustic ablation of tissue, said catheter system comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an array of acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for controlling one or more of said ablation transducers independently of other ones of said transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter body, at least one of said acoustic transducers having an annular configuration designed for generating acoustic energy that radiates in a radial pattern surrounding the circumference of said catheter body, threading said catheter body into said body of said living being such that the transducer array is located in proximity to tissue to be ablated, and controlling at least one of said ablation transducers to provide a desired energy pattern for ablation of tissue at a select location separated from said catheter body.

Claim 49

Independent Claim 216 words

A method for selective acoustic ablation of tissue within the body of a living being, comprising providing a catheter system for acoustic ablation of tissue, said catheter system comprising: a catheter body of extended length constructed for delivery to locations within a body of a living being, said catheter body being adapted for connection to a power source, an array of acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source and for generating acoustic energy, in response to said received power, sufficient for ablation of tissue, and a mechanism for controlling one or more of said ablation transducers independently of other ones of said transducers to produce a desired acoustic energy pattern for ablating tissue at a select location spaced from said catheter body, at least one of said acoustic transducers having an annular configuration designed for generating acoustic energy that radiates in a radial pattern surrounding the circumference of said catheter body, threading said catheter body into said body of said living being such that the transducer array is located in proximity to tissue to be ablated, and controlling at least one of said ablation transducers to provide a desired energy pattern for ablation of tissue at a select location separated from said catheter body.

Claim 50

Dependent Claim 13 words

The method of claim 43, wherein controlling said transducers provides different shaped lesions.

Claim 51

Dependent Claim 14 words

The method of claim 44, wherein the different shaped lesions include a linear lesion.

Claim 52

Dependent Claim 20 words

The method of claim 43, wherein controlling said transducers ablates different discrete portions of tissue without moving said catheter body.

Claim 53

Dependent Claim 15 words

The method of claim 43, wherein controlling includes providing power selectively to the ablation transducers.

Claim 54

Dependent Claim 19 words

The method of claim 43, wherein controlling further includes controlling the phase of power applied to the ablation transducers.

Claim 55

Dependent Claim 18 words

The method of claim 43, wherein controlling includes controlling the frequency of power applied to the ablation transducers.

Claim 56

Dependent Claim 49 words

The method of claim 43 wherein controlling includes controlling said transducers in said array to ablate select discrete tissue locations radially adjacent select transducers in said array by providing power only to said select transducers and choosing a frequency to locate the maxima at the select discrete tissue locations.

Claim 57

Dependent Claim 42 words

The method of claim 43, wherein controlling includes controlling said transducers in said array to ablate a select discrete tissue area by controlling the phase of said transducers in a manner that acoustic energy from multiple transducers causes ablation in said area.

Claim 58

Dependent Claim 21 words

The method of claim 51, wherein said area has a width along the device axis that is shorter than said array.

Claim 59

Dependent Claim 14 words

The method of claim 51, wherein said area is axially beyond said transducer array.

Claim 60

Dependent Claim 22 words

The method of claim 43, wherein controlling includes controlling said transducers to ablate tissue in a ring-like pattern around said catheter body.

Claim 61

Dependent Claim 27 words

The method of claim 54, further comprising delivering said catheter body into an atrium of a heart of said body of said living being for treating fibrillation.

Claim 62

Dependent Claim 34 words

The method of claim 43, wherein said catheter system includes mapping electrodes and said method further includes mapping a heart within said body of said living being to determine a location for said ablation.

Claim 63

Dependent Claim 27 words

The method of claim 43, further comprising: flowing cooling fluid through a catheter lumenal space in heat communication with the transducer array to cool the transducer array.

Claim 64

Dependent Claim 23 words

The method of claim 43, further comprising, before the step of threading: inserting the catheter body into a sheath have a sonolucent portion.

Claim 65

Dependent Claim 28 words

The method of claim 58, further comprising: flowing cooling fluid through a sheath lumenal space in said sheath in heat communication with the transducers to cool the transducers.

Claim 66

Dependent Claim 25 words

The method of claim 59, wherein the step of flowing includes flowing cooling fluid through an outlet port in communication with said sheath lumenal space.

Claim 67

Dependent Claim 30 words

The method of claim 59, wherein the step of flowing includes flowing cooling fluid through a fluid port in communication with a catheter lumenal space and said sheath lumenal space.

Claim 68

Dependent Claim 85 words

A method for tissue ablation comprising: providing a catheter system for acoustic ablation as described in claim 1, positioning said catheter system with an imaging device within a heart of said body of said living being such that the transducer array is located in proximity to cardiac tissue to be ablated, controlling one or more of said ablation transducers to provide a therapeutic energy pattern for ablation of tissue at a select location, and withdrawing the catheter system from the body of the living being.

Claim 69

Independent Claim 177 words

A method for tissue ablation, comprising: positioning a flexible sheath of extended length within a body of a living being, said sheath being at least partially sonolucent, inserting a catheter system having a catheter body of extended length within said sheath, said catheter body being adapted for connection to a power source, providing power from said power source to an acoustic ablation device constructed for receiving power, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and passing fluid through a lumen within said catheter body and through a fluid port in communication with said lumen and said sheath, said fluid port being constructed to cause the fluid to pass between said lumen and a space external to said catheter body and within said sheath, and said lumen and said sheath being constructed to cause the fluid to pass in a longitudinal direction relative to said catheter body and in the vicinity of said acoustic ablation device to cool said acoustic ablation device.

Claim 70

Independent Claim 177 words

A method for tissue ablation, comprising: positioning a flexible sheath of extended length within a body of a living being, said sheath being at least partially sonolucent, inserting a catheter system having a catheter body of extended length within said sheath, said catheter body being adapted for connection to a power source, providing power from said power source to an acoustic ablation device constructed for receiving power, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and passing fluid through a lumen within said catheter body and through a fluid port in communication with said lumen and said sheath, said fluid port being constructed to cause the fluid to pass between said lumen and a space external to said catheter body and within said sheath, and said lumen and said sheath being constructed to cause the fluid to pass in a longitudinal direction relative to said catheter body and in the vicinity of said acoustic ablation device to cool said acoustic ablation device.

Claim 71

Dependent Claim 22 words

The method of claim 63, wherein generating acoustic energy includes radiating acoustic energy from an outer surface of said acoustic ablation device.

Claim 72

Dependent Claim 25 words

The method of claim 64, wherein radiating acoustic energy includes radiation of acoustic energy in a radial pattern surrounding the circumference of said catheter body.

Claim 73

Dependent Claim 27 words

The method of claim 63, wherein passing fluid through said lumen causes fluid to pass in the vicinity of an inner surface of said acoustic ablation device.

Claim 74

Independent Claim 115 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to an acoustic ablation device constructed for receiving power from said power source, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, placing a sonolucent standoff balloon within the body of the living being, inserting said catheter body within said balloon such that said acoustic ablation device is positioned in proximity to tissue to be ablated, and ablating said tissue by passage of acoustic energy through said balloon.

Claim 75

Independent Claim 115 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to an acoustic ablation device constructed for receiving power from said power source, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, placing a sonolucent standoff balloon within the body of the living being, inserting said catheter body within said balloon such that said acoustic ablation device is positioned in proximity to tissue to be ablated, and ablating said tissue by passage of acoustic energy through said balloon.

Claim 76

Independent Claim 107 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to an acoustic ablation device constructed for receiving power from said power source, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and redirecting a portion of said acoustic energy in a direction of another portion of said acoustic energy toward tissue to be ablated, with an acoustic energy redirection device positioned in the vicinity of said acoustic ablation device.

Claim 77

Independent Claim 107 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to an acoustic ablation device constructed for receiving power from said power source, generating acoustic energy with said acoustic ablation device, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and redirecting a portion of said acoustic energy in a direction of another portion of said acoustic energy toward tissue to be ablated, with an acoustic energy redirection device positioned in the vicinity of said acoustic ablation device.

Claim 78

Dependent Claim 15 words

The method of claim 68, wherein redirecting said acoustic energy includes reflecting said acoustic energy.

Claim 79

Dependent Claim 15 words

The method of claim 68, wherein redirecting includes rotating said catheter body about its axis.

Claim 80

Independent Claim 158 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to a linear array of annular acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source, generating acoustic energy with said array of acoustic transducers, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and ablating tissue at a select location spaced from said catheter body by selectively controlling one or more of said ablation transducers independently of others of said ablation transducers to produce a desired acoustic energy pattern, including providing said power to one or more of said transducers independently of other ones of said transducers, and shifting the phase of said power provided to one or more of said transducers independently of other ones of said transducers.

Claim 81

Independent Claim 158 words

A method for tissue ablation, comprising: positioning a catheter body of extended length within a body of a living being, said catheter body being adapted for connection to a power source, providing power to a linear array of annular acoustic transducers disposed along the length of said catheter body and constructed for receiving power from said power source, generating acoustic energy with said array of acoustic transducers, in response to said received power, said acoustic energy being sufficient for ablation of tissue, and ablating tissue at a select location spaced from said catheter body by selectively controlling one or more of said ablation transducers independently of others of said ablation transducers to produce a desired acoustic energy pattern, including providing said power to one or more of said transducers independently of other ones of said transducers, and shifting the phase of said power provided to one or more of said transducers independently of other ones of said transducers.

Claim 82

Dependent Claim 24 words

The method of claim 71, wherein generating acoustic energy includes radiating acoustic energy in a radial pattern surrounding the circumference of said catheter body.

Claim 83

Dependent Claim 24 words

The method of claim 71, wherein providing said power includes switching said power on and off to one or more of said ablation transducers.

Claim 84

Dependent Claim 24 words

The method of claim 73, wherein varying the phase further includes delaying the application of said power to one or more of said transducers.

Claim 85

Dependent Claim 24 words

The method of claim 71, wherein shifting the phase includes varying the phase of said power provided to one or more of said transducers.

Claim 86

Dependent Claim 24 words

The method of claim 71, wherein ablating tissue further includes varying the frequency of said power provided to one or more of said transducers.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2000-05-19	2000-11-18	2001-05-20	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2004-05-19	2004-11-18	2005-05-20	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2008-05-19	2008-11-18	2009-05-20	$7700.00	Window Closed / Lapsed

Acoustic ablation

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