US5610054A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enzymatic RNA molecule targeted against Hepatitis C virus
Assignee: Sirna Therapeutics Inc
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Filing: 1994-01-13
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Granted: 1997-03-11
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Expires: 2014-01-13
Abstract
Abstract An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.
Inventors
- 👤 Kenneth G. Draper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:52
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1131; A; A61; A61P; A61P1/00; A61P1/16; A61P31/00; A61P31/12; C07; C07K; C07K14/00; C07K14/005; C12N15/63; C12N15/79; C12N15/85; C12N15/86; C12Q; C12Q1/00; C12Q1/70; C12Q1/701; C12Q1/706; C12Q1/707; A61K; A61K38/00; C12N2310/00; C12N2310/10; C12N2310/11; C12N2310/111; C12N2310/12; C12N2310/121; C12N2310/122; C12N2310/30; C12N2310/31; C12N2310/315; C12N2310/32; C12N2310/321; C12N2310/322; C12N2310/35; C12N2310/352; C12N2310/3521; C12N2310/353; C12N2310/3531; C12N2310/3533; C12N2310/3535; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24222; C12N2770/24241; C12N2770/24243
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
16 words
An enzymatic RNA molecule which is active to specifically cleave RNA of hepatitis C virus (HCV).
Claim 2
Dependent Claim
16 words
An enzymatic RNA molecule which is active to specifically cleave RNA of hepatitis C virus (HCV).
Claim 3
Dependent Claim
17 words
The enzymatic RNA molecule of claim 1 which specifically cleaves RNA of HCV in the 5'non-translated region.
Claim 4
Dependent Claim
17 words
The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hammerhead motif.
Claim 5
Dependent Claim
26 words
The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis Delta virus, group I intron, or RNaseP RNA motif.
Claim 6
Dependent Claim
37 words
The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence comprising any of SEQ. ID. NOS. 1-8, and wherein said enzymatic RNA molecule is in a hepatitis Delta virus configuration.
Claim 7
Dependent Claim
21 words
The enzymatic RNA molecule of claim 1 which specifically cleaves RNA of HCV in the RNA encoding the core (c) region.
Claim 8
Dependent Claim
22 words
The enzymatic RNA molecule of claim 1 which specifically cleaves RNA of HCV in the RNA encoding the proteases NS3 or NS2NS3.
Claim 9
Dependent Claim
37 words
The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence comprising any of SEQ. ID. NOS. 001-506, and wherein said enzymatic RNA molecule is in a hepatitis Delta virus configuration.
Claim 10
Dependent Claim
35 words
The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence comprising any of SEQ. ID. NOS. 001-506, and wherein said enzymatic RNA molecule is in a hammerhead configuration.
Claim 11
Dependent Claim
22 words
The enzymatic RNA molecule of any of claims 1-5 and 6-9, wherein said enzymatic RNA molecule comprises at least one sugar modification.
Claim 12
Dependent Claim
23 words
The enzymatic RNA molecule of any of claims 1-5 and 6-9, wherein said enzymatic RNA molecule comprises at least one phosphate backbone modification.
Claim 13
Dependent Claim
15 words
The enzymatic RNA molecule of claim 10, wherein said sugar modification is a 2'-O-methyl group.
Claim 14
Dependent Claim
15 words
The enzymatic RNA molecule of claim 11, wherein said phosphate modification is a phosphorothioate group.
Claim 15
Dependent Claim
36 words
An expression vector including a nucleic acid encoding the enzymatic RNA molecule of may of claims 1-5, and 6-9, in a manner which allows expression of said enzymatic RNA molecule within a mammalian cell in vitro.
Claim 16
Dependent Claim
17 words
A mammalian cell including the enzymatic RNA molecule of any of claims 1-5, and 6-9, in vitro.
Claim 17
Dependent Claim
12 words
The cell of claim 15, wherein said cell is a human cell.
References Cited (Backward Citations)
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