US5580569A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Article for tissue-specific delivery of therapeutic agents
Assignee: Individual
•
Filing: 1993-11-04
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Granted: 1996-12-03
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Expires: 2013-11-04
Abstract
Abstract An article for tissue-specific delivery of therapeutic agents constitutes a substrate of a material that is biodegradable in situ in human tissue, which substrate is configured into a projectile and proportioned for insertion into a channel of an endoscope, the substrate having incorporated thereinto selectable therapeutic agents to be delivered, the projectile including, upon an exterior surface, a capacity for tissue affixation to the tissue of interest.
Inventors
- 👤 Vincent C. Giampapa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 19:15
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
76 words
An article for tissue-specific delivery of therapeutic agents, comprising: a substrate of a material which is bioerodable in situ in human tissue, said substrate configured as a projectile and proportioned for insertion into a channel of an endoscopic instrument, said substrate comprising a matrix including therapeutic agents to be selectably delivered as a function of the bioerosion of said substrate, said projectile including, upon an exterior surface thereof, an angiogenic agent and means for tissue affixation.
Claim 2
Dependent Claim
76 words
An article for tissue-specific delivery of therapeutic agents, comprising: a substrate of a material which is bioerodable in situ in human tissue, said substrate configured as a projectile and proportioned for insertion into a channel of an endoscopic instrument, said substrate comprising a matrix including therapeutic agents to be selectably delivered as a function of the bioerosion of said substrate, said projectile including, upon an exterior surface thereof, an angiogenic agent and means for tissue affixation.
Claim 3
Dependent Claim
17 words
The article as recited in claim 1, in which said tissue affixation means comprises: tissue anchoring means.
Claim 4
Dependent Claim
17 words
The article as recited in claim 1, in which said tissue affixation means comprises: tissue adhesion means.
Claim 5
Dependent Claim
30 words
The article as recited in claim 2, in which said tissue anchoring means comprises: a material comprising means for bioerosion at a slower rate than said substrate of said article.
Claim 6
Dependent Claim
32 words
The article as recited in claim 1, wherein said substrate includes an agent or growth factor selected from the agents consisting of: a vaso-inductive agent, a vaso-inhibiting agent, and tumor necrosis factors.
Claim 7
Dependent Claim
38 words
The article as recited in claim 5, in which said vaso-inductive agent is selected from the group consisting of: vascular endothelial growth factor, platelet growth factor, vascular permeability growth factor, fibroblast growth factor, and transforming growth factor beta.
Claim 8
Dependent Claim
38 words
The article as recited in claim 1, in which said therapeutic agents to be delivered are selected from the group consisting of chemotherapeutics, tumorcidals, analgesics, hormones, enzymes, anesthetics, anti-inflammatories, antibiotics, immunoglobulins, gene therapeutics, and cellular replacement therapeutics and.
Claim 9
Dependent Claim
36 words
The article as recited in claim 1 in which the material of said substrate is selected from the group of materials consisting of processed sheep dermal collagen, Hench's bioglass, fibrinogen, polyimino-carbonates, polyglycolic acid and polylactic acid.
References Cited (Backward Citations)
US4771757A
Cited
US4863428A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-03 | 2000-06-03 | 2000-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-03 | 2004-06-03 | 2004-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-03 | 2008-06-03 | 2008-12-03 | $7700.00 | Window Closed / Lapsed |