US5571523A
Expired / Lapsed
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Antioxidant-induced apoptosis in vascular smooth muscle cells
Assignee: Harvard University
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Filing: 1995-03-09
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Granted: 1996-11-05
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Expires: 2015-03-09
Abstract
Abstract A method of inhibiting arteriosclerosis or smooth muscle cell proliferation by identifying an animal having an artery suspected of needing such inhibition and contacting the artery with an apoptosis-inducing amount of an antioxidant.
Inventors
- 👤 Mu-En Lee
- 👤 Edgar Haber
- 👤 Jer-Chia Tsai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:45
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61K; A61K31/00; A61K31/095; A61K31/10; A61K31/185; A61K31/19; A61K31/195; A61K31/197; A61K31/198; A61K31/33; A61K31/38; A61K31/381; A61K31/395; A61K31/41; A61K31/425; A61K31/495; A61K31/505; A61K31/513; A61K38/00; A61K38/04; A61K38/06; A61K38/063; A61P; A61P9/00; A61P9/10; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/422
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
31 words
A method of inhibiting arteriosclerosis in an animal, comprising identifying an animal having an artery suspected of needing said inhibition and contacting said artery with an apoptosis-inducing amount of an antioxidant.
Claim 2
Independent Claim
31 words
A method of inhibiting arteriosclerosis in an animal, comprising identifying an animal having an artery suspected of needing said inhibition and contacting said artery with an apoptosis-inducing amount of an antioxidant.
Claim 3
Dependent Claim
11 words
The method of claim 1, wherein said animal is a human.
Claim 4
Dependent Claim
12 words
The method of claim 1, wherein said antioxidant is a sulfur-containing antioxidant.
Claim 5
Dependent Claim
12 words
The method of claim 3, wherein said antioxidant comprises a sulfhydryl group.
Claim 6
Dependent Claim
10 words
The method of claim 3, wherein said antioxidant is N-acetylcysteine.
Claim 7
Dependent Claim
10 words
The method of claim 3, wherein said antioxidant is pyrrolidinedithiocarbamate.
Claim 8
Dependent Claim
38 words
The method of claim 3, wherein said antioxidant is chosen from the group consisting of 2-mercaptoethanol, dithiothreitol, glutathione, S-adenosylmethionine, dithiocarbamate, propylthiouracil, dimethylsulfoxide, cysteine, methionine, cysteamine, oxo-thiazolidinecarboxylate, timonacic acid, WR-2721, malotilate, 1,2-dithiol 3-thione, 1,3-dithiol 2-thione, lipoamide, sulfarlem, and oltipraz.
Claim 9
Dependent Claim
16 words
The method of claim 3, wherein said antioxidant is a mixture of two or more antioxidants.
Claim 10
Dependent Claim
12 words
The method of claim 8, wherein said mixture comprises N-acetylcysteine and pyrrolidinedithiocarbamate.
Claim 11
Independent Claim
32 words
A method of inhibiting vascular smooth muscle cell proliferation in an animal, comprising identifying an animal in need of said inhibition, and introducing an antioxidant into a blood vessel of said animal.
Claim 12
Independent Claim
32 words
A method of inhibiting vascular smooth muscle cell proliferation in an animal, comprising identifying an animal in need of said inhibition, and introducing an antioxidant into a blood vessel of said animal.
Claim 13
Dependent Claim
11 words
The method of claim 10, wherein said animal is a human.
Claim 14
Dependent Claim
15 words
The method of claim 10, wherein said proliferation occurs at the site of vascular injury.
Claim 15
Dependent Claim
12 words
The method of claim 10, wherein said antioxidant is a sulfur-containing antioxidant.
Claim 16
Dependent Claim
12 words
The method of claim 13, wherein said antioxidant comprises a sulfhydryl group.
Claim 17
Dependent Claim
10 words
The method of claim 13, wherein said antioxidant is N-acetylcysteine.
Claim 18
Dependent Claim
10 words
The method of claim 13, wherein said antioxidant is pyrrolidinedithiocarbamate.
References Cited (Backward Citations)
US5464833A
Cited
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| 3.5 Years (Year 4) | 1999-11-05 | 2000-05-06 | 2000-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-05 | 2004-05-06 | 2004-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-05 | 2008-05-06 | 2008-11-05 | $7700.00 | Window Closed / Lapsed |