US5571149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
Assignee: FISHER-WALLACE LABORATORIES LLC
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Filing: 1994-04-13
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Granted: 1996-11-05
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Expires: 2014-04-13
Abstract
Abstract The present invention pertains to a portable non-invasive electronic apparatus which can be used to relieve pain or alter the symptoms of certain neurological dysfunctions. A specifically contoured constant current and current limited waveform is generated and applied to selectively positioned electrodes. A program controlled processor tracks usage of the unit to prevent abuse and monitor progress. An overall treatment regimen centered on the stimulator may be effected simply and safely. The invention also provides an apparatus and method for the iontophoretic topical administration of a pharmaceutical agent. The apparatus is operated in a monopolar mode with a particular complex waveform which synergistically enhances the amount of various neurobiochemical species in the cerebral spinal fluid and the blood plasma.
Inventors
- 👤 Saul Liss
- 👤 Bernard Liss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:30
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/36014; A61N1/36021; A61N1/325
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
162 words
In combination, in a system for the iontophoretic topical delivery of a pharmaceutically active agent, said system comprising: a. means for generating a substantially constant current pulsed DC output voltage; b. means for converting said output voltage into an n-modulated output adjustable constant current waveform, wherein n is an integer; c. a pharmaceutically active agent effective for topical administration; d. contact means for containing and delivering said pharmaceutically active agent to a topical area of a patient in need of treatment, said contact means including at least two electrodes; e. means for directing said n-modulated output waveform to said contact means; wherein said n-modulated output waveform comprises a first waveform component ranging between 1 and 300,000 KHz, a second waveform component ranging between 10 and 199,000 Hz, and a third waveform component ranging between 100 and 300,000 Hz, and each waveform component is substantially time invariant and distinct from said other waveform components, said double modulated output waveform having a monopolar characteristic.
Claim 2
Dependent Claim
162 words
In combination, in a system for the iontophoretic topical delivery of a pharmaceutically active agent, said system comprising: a. means for generating a substantially constant current pulsed DC output voltage; b. means for converting said output voltage into an n-modulated output adjustable constant current waveform, wherein n is an integer; c. a pharmaceutically active agent effective for topical administration; d. contact means for containing and delivering said pharmaceutically active agent to a topical area of a patient in need of treatment, said contact means including at least two electrodes; e. means for directing said n-modulated output waveform to said contact means; wherein said n-modulated output waveform comprises a first waveform component ranging between 1 and 300,000 KHz, a second waveform component ranging between 10 and 199,000 Hz, and a third waveform component ranging between 100 and 300,000 Hz, and each waveform component is substantially time invariant and distinct from said other waveform components, said double modulated output waveform having a monopolar characteristic.
Claim 3
Dependent Claim
29 words
The system of claim 1 wherein said first waveform component has a 50% duty cycle, and said second waveform component has a 75% duty cycle but not limited thereto.
Claim 4
Dependent Claim
18 words
The system of claim 1, wherein the first waveform ranges from about 10 Hz to about 100 KHz.
Claim 5
Dependent Claim
14 words
The system of claim 3, wherein the first waveform ranges from about 10-50 KHz.
Claim 6
Dependent Claim
19 words
The system of claim 4, wherein said second waveform component ranges from about 10 KHz to about 20 KHz.
Claim 7
Dependent Claim
18 words
The system of claim 1, wherein said third waveform ranges from about 100 Hz to about 100 KHz.
Claim 8
Dependent Claim
31 words
The system of claim 1, wherein said first waveform component is approximately 15,000 Hz, said second waveform component is approximately 15 Hz, and said third waveform component is approximately 500 Hz.
Claim 9
Dependent Claim
32 words
The system of claim 1, wherein the pharmaceutical agent is selected from the group consisting of anti-inflammatory agents, proteins and/or hormones, nicotine, antianginal and/or vasodilator compounds, vitamins and cofactors, antihypertensives, and anesthetics.
Claim 10
Dependent Claim
25 words
The system of claim 8, wherein the pharmaceutical agent is selected from the group consisting of hydrocortisone, insulin, nicotine, nitroglycerin, nicotinic acid, propranolol, and lidocaine.
Claim 11
Dependent Claim
148 words
In combination, in a system for the treatment of certain neural responsive conditions, said system comprising: a. means for generating a substantially constant current pulsed DC output voltage; b. means for converting said output voltage into an n-modulated output adjustable constant current waveform; c. contact means comprising at least two contacts for conducting said n-modulated output adjustable constant current to a mammalian host: d. means for directing said n-modulated output waveform across said at least two contacts; wherein said n-modulated output waveform comprises a first waveform component ranging between 1 KHz and 300 GHz, a second waveform component ranging between 1 and 199,000 Hz, a third waveform component ranging between 100 and 300,000 Hz, and a fourth waveform component ranging from 0.1 Hz to 1,000 Hz, each waveform component being substantially time invariant and distinct from said other waveform components, said n-modulated output waveform having a monopolar characteristic.
Claim 12
Dependent Claim
148 words
In combination, in a system for the treatment of certain neural responsive conditions, said system comprising: a. means for generating a substantially constant current pulsed DC output voltage; b. means for converting said output voltage into an n-modulated output adjustable constant current waveform; c. contact means comprising at least two contacts for conducting said n-modulated output adjustable constant current to a mammalian host: d. means for directing said n-modulated output waveform across said at least two contacts; wherein said n-modulated output waveform comprises a first waveform component ranging between 1 KHz and 300 GHz, a second waveform component ranging between 1 and 199,000 Hz, a third waveform component ranging between 100 and 300,000 Hz, and a fourth waveform component ranging from 0.1 Hz to 1,000 Hz, each waveform component being substantially time invariant and distinct from said other waveform components, said n-modulated output waveform having a monopolar characteristic.
Claim 13
Dependent Claim
33 words
The system of claim 10, wherein said first waveform component has a 50% duty cycle and said second waveform component has from about a 50% duty cycle to about a 75% duty cycle.
Claim 14
Dependent Claim
17 words
The system of claim 10, further comprising a means for intermittently reversing polarity of said n-modulated waveform.
Claim 15
Dependent Claim
17 words
The system of claim 10, wherein said first waveform component is a carrier frequency of 20-100 GHz.
Claim 16
Dependent Claim
20 words
The system of claim 10, wherein said second waveform component is a modulation frequency in the range of 10-1000 Hz.
Claim 17
Dependent Claim
18 words
The system of claim 10, wherein said third waveform component is a modulation frequency of 15 KHz±5 KHz.
Claim 18
Dependent Claim
20 words
The system of claim 10, wherein said fourth waveform component is a modulation frequency in the range of 1-50 Hz.
Claim 19
Dependent Claim
59 words
The system of claim 10, wherein said first waveform component has a frequency in the range of 50-75 GHz, said second waveform component has a frequency in the range of 500±50 Hz, said third waveform component has a frequency in the range of 15 KHz±2 KHz, and said fourth waveform has a frequency in the range of 5-25 Hz.
Claim 20
Dependent Claim
117 words
In combination in a method for the treatment of pain or symptoms of neural dysfunction distress, comprising the steps of: a. developing a treatment regimen comprising a series of individual treatment sessions; b. programming an n-modulated waveform generator with said treatment regimen; c. monitoring and recording an implementation of said treatment regimen with said n-modulated waveform generator; and d. replaying a historical account of said treatment regimen for review; wherein said n-modulated waveform generator generates a first waveform component ranging between 1 KHz and 300 GHz, a second waveform component ranging between 10 and 199,000 Hz, a third waveform component ranging between 100 and 300,000 Hz, and fourth waveform component ranging from 0.1 Hz to 1,000 Hz.
Claim 21
Dependent Claim
117 words
In combination in a method for the treatment of pain or symptoms of neural dysfunction distress, comprising the steps of: a. developing a treatment regimen comprising a series of individual treatment sessions; b. programming an n-modulated waveform generator with said treatment regimen; c. monitoring and recording an implementation of said treatment regimen with said n-modulated waveform generator; and d. replaying a historical account of said treatment regimen for review; wherein said n-modulated waveform generator generates a first waveform component ranging between 1 KHz and 300 GHz, a second waveform component ranging between 10 and 199,000 Hz, a third waveform component ranging between 100 and 300,000 Hz, and fourth waveform component ranging from 0.1 Hz to 1,000 Hz.
Claim 22
Dependent Claim
59 words
The method of claim 18, wherein said first waveform component has a frequency in the range of 50-75 GHz, said second waveform component has a frequency in the range of 500±50 Hz, said third waveform component has a frequency in the range of 15 KHz±2 KHz, and said fourth waveform has a frequency in the range of 5-25 Hz.
Claim 23
Dependent Claim
26 words
The method of claim 18, wherein said waveform generator further includes an abuse-preventing circuit that automatically stops any waveform output when usage exceeds a pre-programmed limit.
References Cited (Backward Citations)
US5135478A
Cited
US5109847A
Cited
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