US5571083A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and system for cell transplantation
Assignee: Individual
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Filing: 1995-06-06
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Granted: 1996-11-05
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Expires: 2015-06-06
Abstract
Abstract A system and method are disclosed for internally delivering cellular transplants to a patient under the automatic control of a computer. A diagnostic imaging modality, such as a CAT or MRI scanning system, generates one or more images of the patient's anatomy showing an anatomical region into which it is desired to deliver the cellular transplants. For each such image, location coordinates with respect to a patient support means are calculated by the computer for each individual pixel making up the image. Location coordinates arc then defined for a select body region corresponding to pixels of the anatomical image(s) designated by a user of the system to receive the cellular transplants. The computer then operates a manipulator arm in order to position a tranplantation tool such as an injection needle or catheter mounted on the arm adjacent to the select body region. In the case of an injection needle, the needle is inserted into the region at the appropriate depth, and an injector is operated under computer control to force a predetermined amount of a transplant medium containing the cellular transplants out of a lumen within the injection needle and into the select body region.
Inventors
- 👤 Jerome H. Lemelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:42
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/561; G01R33/563; G01R33/56308; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
236 words
A system for delivering cellular transplant material to a patient comprising: a computer; a tranplantation tool for delivering a fluid transplant medium containing cellular transplants into tissue; an automatic manipulator including a manipulator arm assembly for supporting and operating said tranplantation tool and a power driving device for moving said manipulator arm along multiple axes; a patient support structure having a support surface; a power driven device operable under computer control for moving said support surface and said manipulator arm assembly relative to one another to cause the manipulator arm assembly to controllably move said tranplantation tool into select regions of the patient's body; a scanning system including an imaging device for generating image information of select anatomical regions of the patient's body; a plurality of sensors for sensing the relative positions of said patient support, said manipulator arm assembly, and said scanning imaging device, and generating and feeding coded signals representing the sensed positions to said computer; a first computer program for calculating location coordinates of select body regions defined by pixels of images produced by said scanning imaging device and using the coded signals representing the sensed relative positions of said patient support means and said imaging device; and a second computer program for calculating location coordinates of said injection needle and determining when said tranplantation tool is located at said select body region into which it is desired to deliver said cellular transplants.
Claim 2
Independent Claim
236 words
A system for delivering cellular transplant material to a patient comprising: a computer; a tranplantation tool for delivering a fluid transplant medium containing cellular transplants into tissue; an automatic manipulator including a manipulator arm assembly for supporting and operating said tranplantation tool and a power driving device for moving said manipulator arm along multiple axes; a patient support structure having a support surface; a power driven device operable under computer control for moving said support surface and said manipulator arm assembly relative to one another to cause the manipulator arm assembly to controllably move said tranplantation tool into select regions of the patient's body; a scanning system including an imaging device for generating image information of select anatomical regions of the patient's body; a plurality of sensors for sensing the relative positions of said patient support, said manipulator arm assembly, and said scanning imaging device, and generating and feeding coded signals representing the sensed positions to said computer; a first computer program for calculating location coordinates of select body regions defined by pixels of images produced by said scanning imaging device and using the coded signals representing the sensed relative positions of said patient support means and said imaging device; and a second computer program for calculating location coordinates of said injection needle and determining when said tranplantation tool is located at said select body region into which it is desired to deliver said cellular transplants.
Claim 3
Dependent Claim
55 words
A system in accordance with claim 1 further comprising an electronic display device for displaying images and allowing the designation and inputting to said computer of select pixels of said images that correspond to select regions of the patient's body into which it is desired to dispose said transplantation tool and deliver said cellular transplants.
Claim 4
Dependent Claim
49 words
A system in accordance with claim 1 wherein said imaging device includes an ultrasonic pulse-echo transducing means and wherein said actuator for effecting relative movement between said patient support surface and said imaging device includes a manipulator arm assembly for positioning said ultrasonic transducer under control of said computer.
Claim 5
Dependent Claim
17 words
A system in accordance with claim 1 wherein said scanning system includes a magnetic resonance imaging device.
Claim 6
Dependent Claim
17 words
A system in accordance with claim 1 wherein said scanning system includes a computerized axial tomography scanner.
Claim 7
Dependent Claim
28 words
A system in accordance with claim 1 further comprising an actuator for effecting relative movement between said patient support and said imaging device under control of said computer.
Claim 8
Dependent Claim
51 words
A system in accordance with claim 1 wherein said transplantation tool is an injector assemby comprising an injection needle having a conduit therein for flowing a fluid transplant medium containing cellular transplants into tissue in which the needle is inserted and an injector for forcing the transplant medium through said conduit.
Claim 9
Dependent Claim
39 words
A system in accordance with claim 7 further comprising a program for automatically controlling movement of said manipulator arm assembly so as to cause the insertion of said injection needle into said select body region at a desired depth.
Claim 10
Dependent Claim
37 words
A system in accordance with claim 7 further comprising a program for automatically controlling operation of said injector so as to cause it to inject a pretermined amount of said transplant medium into said select body region.
Claim 11
Dependent Claim
36 words
A system in accordance with claim 1 wherein said transplantation tool is a catheter having an outflow port for delivering transplant cells to an intraductal or other internal body site into which the catheter is inserted.
Claim 12
Independent Claim
257 words
A method for internally delivering cellular transplant material into a patient, comprising the steps of: supporting a patient on a patient support which is relatively movable with respect to a tranplantation tool mounted on a computer controlled manipulator arm to permit the tool to be inserted into select regions of the patient's body under control of a computer; scanning a select portion of the patient's body with a scanning device so as to generate scanning information relating to select regions of the patient's body; sensing the relative positions of said patient support, said tranplantation tool, and said scanning imaging device, and generating and feeding coded signals representing the sensed positions to a computer in digitized form; operating the computer to calculate location coordinates of a select body region requiring treatiment and defined by select pixels making of the images produced by said scanning imaging device, using the coded signals to predeterminately and relatively position of said patient support means and said scanning device; designating and inputting to a computer information defining select pixels of images produced by said scanning device which information represents select regions of the patient's body to which it is desired to deliver select cellular transplant material; calculating location coordinates of said injection device and determining if an operating end of said tranplantation tool is properly located at a select body region into which it is desired to deliver the cellular transplants; and, when so located, operating said tranplantation tool to deliver a select amount of said transplant medium into said select body region.
Claim 13
Independent Claim
257 words
A method for internally delivering cellular transplant material into a patient, comprising the steps of: supporting a patient on a patient support which is relatively movable with respect to a tranplantation tool mounted on a computer controlled manipulator arm to permit the tool to be inserted into select regions of the patient's body under control of a computer; scanning a select portion of the patient's body with a scanning device so as to generate scanning information relating to select regions of the patient's body; sensing the relative positions of said patient support, said tranplantation tool, and said scanning imaging device, and generating and feeding coded signals representing the sensed positions to a computer in digitized form; operating the computer to calculate location coordinates of a select body region requiring treatiment and defined by select pixels making of the images produced by said scanning imaging device, using the coded signals to predeterminately and relatively position of said patient support means and said scanning device; designating and inputting to a computer information defining select pixels of images produced by said scanning device which information represents select regions of the patient's body to which it is desired to deliver select cellular transplant material; calculating location coordinates of said injection device and determining if an operating end of said tranplantation tool is properly located at a select body region into which it is desired to deliver the cellular transplants; and, when so located, operating said tranplantation tool to deliver a select amount of said transplant medium into said select body region.
Claim 14
Dependent Claim
53 words
A method in accordance with claim 11 wherein said imaging device and said patient support are relatively movable with respect to each other and said method further comprising the step of selectively positioning said scanning device under computer control so as cause it to generate images of select portions of the patient's body.
Claim 15
Dependent Claim
51 words
A method in accordance with claim 11 wherein said transplantation tool is an injector assemby comprising an injection needle having a conduit therein for flowing a fluid transplant medium containing cellular transplants into tissue in which the needle is inserted and an injector for forcing the transplant medium through said conduit.
Claim 16
Dependent Claim
59 words
A method in accordance with claim 13 further comprising the steps of automatically moving said injection device under control of said computer until said injection device is inserted into tissue of said select body region into which select tissue it is desired to deliver said cellular transplant material and automatically injecting a select amount of said transplant medium therein.
Claim 17
Dependent Claim
25 words
A method in accordance with claim 14 further comprising the step of computer controlling the amount of transplant material injected into said select body region.
Claim 18
Dependent Claim
30 words
A method in accordance with claim 13 further comprising the step of injecting a medicinal agent into said select body region through a second conduit extending through said injection needle.
Claim 19
Dependent Claim
20 words
A method in accordance with claim 13 wherein said hepatocytes are injected into a branch of the patient's portal vein.
Claim 20
Dependent Claim
36 words
A method in accordance with claim 11 wherein said transplantation tool is a catheter having an outflow port for delivering transplant cells to an intraductal or other internal body site into which the catheter is inserted.
Claim 21
Dependent Claim
13 words
A method in accordance with claim 11 wherein said cellular transplants comprise hepatocytes.
Claim 22
Dependent Claim
16 words
A method in accordance with claim 11 wherein said hepatocytes are injected into the patient's spleen.
References Cited (Backward Citations)
US5474687A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-11-05 | 2000-05-06 | 2000-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-05 | 2004-05-06 | 2004-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-05 | 2008-05-06 | 2008-11-05 | $7700.00 | Window Closed / Lapsed |