US5567720A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutically active agents that impede amyloid formation in vivo
Assignee: DMS Pharmaceutical Inc
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Filing: 1994-06-27
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Granted: 1996-10-22
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Expires: 2014-06-27
Abstract
Abstract Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10 -5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.
Inventors
- 👤 Paul Averback
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 14:08
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6893; G01N33/6896; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/395; A61K31/40; A61K31/41; A61K31/42; A61K31/495; A61K31/505; A61K31/55; A61K31/63; A61K31/655; A61K31/70; C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; C07H19/00; C07H19/02; C07H19/04; C07H19/06; G01N33/5005; G01N33/5008; G01N33/5082; G01N33/5088; G01N2333/00; G01N2333/435; G01N2333/46; G01N2333/47; G01N2333/4701; G01N2333/4709; G01N2500/00; G01N2800/00; G01N2800/28; G01N2800/2814; G01N2800/2821; Y; Y10; Y10S; Y10S436/00; Y10S436/811; Y10S530/00; Y10S530/827; Y10S530/839
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
59 words
A method of treating cerebral amyloidosis, comprising the step of administering to a subject, in whom amyloid formation is anticipated, a pharmaceutically effective amount of a compound that inhibits formation of amyloid fibrils when administered, at an in-tissue concentration of about 10 -5 M or less, to a test animal that has received an intracerebral injection of dense microspheres.
Claim 2
Independent Claim
59 words
A method of treating cerebral amyloidosis, comprising the step of administering to a subject, in whom amyloid formation is anticipated, a pharmaceutically effective amount of a compound that inhibits formation of amyloid fibrils when administered, at an in-tissue concentration of about 10 -5 M or less, to a test animal that has received an intracerebral injection of dense microspheres.
Claim 3
Dependent Claim
37 words
A method according to claim 1, wherein said compound inhibits formation of amyloid fibrils by acting on DMS components such that a structural transition of DMS protein in the brain to a β-pleated sheet conformation is prevented.
Claim 4
Dependent Claim
27 words
A method according to claim 1, wherein said subject does not display clinical or other evidence indicative of Alzheimer's disease or dementia associated with another disease state.
Claim 5
Dependent Claim
24 words
A method according to claim 3, wherein said administering prevents a decline in brain function in said subject, said decline being short of dementia.
Claim 6
Dependent Claim
34 words
A method according to claim 1, wherein symptoms of dementia are not evident in said subject but said subject tests positive for increased risk of Alzheimer's disease or dementia due to another disease state.
Claim 7
Dependent Claim
19 words
A method according to claim 5, wherein said subject tests positive for presence of DMS disruption in the brain.
Claim 8
Dependent Claim
29 words
A method according to claim 1, wherein said compound is selected from the group consisting of pyrimethamine, cromolyn sodium, erythromycin, purpurogallin, tartrazine, sulfanilamide, benzopurpurine 4B, 29H,31H-phthalocyanine, 5-methyl-2-thiouridine and 1,2-benzlsoxazole.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-22 | 2000-04-22 | 2000-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-22 | 2004-04-22 | 2004-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-22 | 2008-04-22 | 2008-10-22 | $7700.00 | Window Closed / Lapsed |