US5567434A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of liposome and lipid complex compositions
Assignee: University of California, San Diego
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Filing: 1995-06-07
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Granted: 1996-10-22
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Expires: 2015-06-07
Abstract
Abstract Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and either injecting the resulting solution into an aqueous solution, or the aqueous solution into the resulting solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.
Inventors
- 👤 Francis C. Szoka, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 19:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/543; A61K47/544; A61K9/10; A61K9/127; A61K9/1277; Y; Y10; Y10S; Y10S436/00; Y10S436/829
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
90 words
A product of the process for preparing a lipid suspension of particle size less than about 10,000 nm in diameter encapsulating a therapeutically, pharmaceutically or diagnostically useful compound, which process comprises: dissolving said useful compound and an encapsulating amount of a suitable lipid in a sufficient amount of a solvent mixture comprising a non-halogenated hydrocarbon aprotic solvent to provide a compound/lipid solution; and extruding said compound/lipid solution through a suitably-sized aperture into an aqueous solution to form a lipid-compound suspension of particle size less than about 10,000 nm in diameter.
Claim 2
Dependent Claim
90 words
A product of the process for preparing a lipid suspension of particle size less than about 10,000 nm in diameter encapsulating a therapeutically, pharmaceutically or diagnostically useful compound, which process comprises: dissolving said useful compound and an encapsulating amount of a suitable lipid in a sufficient amount of a solvent mixture comprising a non-halogenated hydrocarbon aprotic solvent to provide a compound/lipid solution; and extruding said compound/lipid solution through a suitably-sized aperture into an aqueous solution to form a lipid-compound suspension of particle size less than about 10,000 nm in diameter.
Claim 3
Dependent Claim
29 words
The product-by-process of claim 1 further comprising a lipid suspension of liposomes and a useful compound selected from the group consisting of cisplatin, doxorubicin, epinephrine, mebendazole, niridazole, and taxol.
Claim 4
Dependent Claim
28 words
The product-by-process of claim 1 further comprising a lipid suspension of lipidic particles and a useful compound selected from the group consisting of amphotericin B, nystatin, and primaricin.
Claim 5
Dependent Claim
30 words
The product-by-process of claim 1 wherein the lipid-compound suspension has a particle size between 20 and 600 μm and wherein the therapeutically, pharmaceutically, or diagnostically useful compound is amphotericin B.
References Cited (Backward Citations)
US5277914A
Cited
US5077057A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1999-10-22 | 2000-04-22 | 2000-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-22 | 2004-04-22 | 2004-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-22 | 2008-04-22 | 2008-10-22 | $7700.00 | Window Closed / Lapsed |