US5565448A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicament
Assignee: GlaxoSmithKline LLC
•
Filing: 1993-02-24
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Granted: 1996-10-15
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Expires: 2013-02-24
Abstract
Abstract The present invention relates to the treatment and prevention of conditions wherein protein Kinase C inhibition is indicated.
Inventors
- 👤 Ponnal Nambi
- 👤 Ashok D. Patil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61P; A61P1/00; A61P1/16; A61P19/00; A61P19/02; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P37/00; A61P37/02; A61P37/04; A61P43/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
40 words
A method of treating inflammation in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR2## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
40 words
A method of treating inflammation in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR2## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
8 words
The method of claim 1 for treating arthritis.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 6
Independent Claim
41 words
A method of treating renal failure in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR3## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 7
Independent Claim
41 words
A method of treating renal failure in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR3## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
16 words
The method of claim 5 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
16 words
The method of claim 5 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 10
Independent Claim
41 words
A method of treating septic shock in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR4## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 11
Independent Claim
41 words
A method of treating septic shock in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR4## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
16 words
The method of claim 8 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
16 words
The method of claim 8 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 14
Independent Claim
43 words
A method of treating central nervous system disorders in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR5## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 15
Independent Claim
43 words
A method of treating central nervous system disorders in a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR5## in which R is H or Br; or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
16 words
The method of claim 11 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
16 words
The method of claim 11 wherein the compound is 4-(2-amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo(2,3-c)azepine-8-one or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
WO1987007274A2
Cited
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