US5552162A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for improvement of scar size and appearance
Assignee: Arch Development Corp
•
Filing: 1993-02-09
•
Granted: 1996-09-03
•
Expires: 2013-02-09
Abstract
Abstract A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar. Further disclosed is a method for improving the size and appearance of a scar comprises covering said scar with a thermal insulating material that elevates the surface temperature of the scar and that contains a therapeutically effective amount of a medicament.
Inventors
- 👤 Raphael C. Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:33
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/008; A61L26/0066; A61L2300/00; A61L2300/40; A61L2300/432
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
81 words
A method for improving the size and appearance of an existing hypertrophic or keloid scar comprising stimulating collagenase activity in said scar for a period of time sufficient to result in a noticeable improvement in said scar, wherein stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar from about 0.5° C. to about 5° C., wherein said thermal insulating material contains a therapeutically effective amount of a medicament.
Claim 2
Independent Claim
81 words
A method for improving the size and appearance of an existing hypertrophic or keloid scar comprising stimulating collagenase activity in said scar for a period of time sufficient to result in a noticeable improvement in said scar, wherein stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar from about 0.5° C. to about 5° C., wherein said thermal insulating material contains a therapeutically effective amount of a medicament.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the medicament is a calcium antagonist.
Claim 4
Dependent Claim
23 words
The method of claim 2 wherein the calcium antagonist is a calmodulin inhibitor, a Protein Kinase C inhibitor, or a calcium transport blocker.
Claim 5
Dependent Claim
21 words
The method of claim 3 wherein the calcium transport blocker is verapamil, nifedipine, nicardipine, nimodipine, diltiazem, cobalt chloride or nickel chloride.
Claim 6
Dependent Claim
23 words
The method of claim 3 wherein the calcium transport blocker is a phenylalkylamine compound, a benzothiazepine compound, or a biologically compatible polyvalent salts.
Claim 7
Dependent Claim
13 words
The method of claim 3 wherein the calmodulin inhibitor is trifluoperazine or tamoxifen.
Claim 8
Independent Claim
50 words
A method for improving the size and appearance of a hypertrophic or keloid scar comprising covering said scar with a hydrogel-containing composition for a period of time sufficient to reduce the amount of scar tissue, thereby resulting in a noticeable improvement in said scar after removal of said hydrogel-containing composition.
Claim 9
Independent Claim
50 words
A method for improving the size and appearance of a hypertrophic or keloid scar comprising covering said scar with a hydrogel-containing composition for a period of time sufficient to reduce the amount of scar tissue, thereby resulting in a noticeable improvement in said scar after removal of said hydrogel-containing composition.
Claim 10
Dependent Claim
18 words
The method according to claim 7 wherein said hydrogel-containing composition comprises a therapeutically effective amount of a medicament.
Claim 11
Dependent Claim
12 words
The method of claim 8 wherein the medicament is a calcium antagonist.
Claim 12
Dependent Claim
23 words
The method of claim 9 wherein the calcium antagonist is a calmodulin inhibitor, a Protein Kinase C inhibitor, or a calcium transport blocker.
Claim 13
Dependent Claim
21 words
The method of claim 10 wherein the calcium transport blocker is verapamil, nifedipine, nicardipine, nimodipine, diltiazem, cobalt chloride or nickel chloride.
Claim 14
Dependent Claim
23 words
The method of claim 10 wherein the calcium transport blocker is a phenylalkylamine compound, a benzothiazepine compound, or a biologically compatible polyvalent salts.
Claim 15
Dependent Claim
13 words
The method of claim 10 wherein the calmodulin inhibitor is trifluoperazine or tamoxifen.
References Cited (Backward Citations)
US4272518A
Cited
US4659700A
Cited
US5013769A
Cited
WO1991001624A2
Cited
US5132119A
Cited
WO1991002497A1
Cited
WO1991006323A1
Cited
WO1994002130A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-09-03 | 2000-03-04 | 2000-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-09-03 | 2004-03-04 | 2004-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-09-03 | 2008-03-04 | 2008-09-03 | $7700.00 | Window Closed / Lapsed |