US5543328A
Expired / Lapsed
US
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Adenoviruses having modified fiber proteins
Assignee: Genetic Therapy Inc
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Filing: 1993-08-13
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Granted: 1996-08-06
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Expires: 2013-08-13
Abstract
Abstract An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.
Inventors
- 👤 Alan McClelland
- 👤 Susan C. Stevenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:26
CPC Classifications
C; C12; C12N; C12N7/00; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/52; C07K14/525; C07K14/775; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; C12N15/87; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/644; C12Y; C12Y304/00; C12Y304/21; C12Y304/21022; A; A61; A61K; A61K38/00; A61K48/00; C07K2319/00; C12N2710/00; C12N2710/00011; C12N2710/10011; C12N2710/10311; C12N2710/10322; C12N2710/10341; C12N2710/10343; C12N2710/10351; C12N2810/00; C12N2810/50; C12N2810/80; C12N2810/85; C12N2810/852; C12N2810/853
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
31 words
An adenovirus wherein at least a portion of the adenovirus fiber protein is removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 2
Dependent Claim
31 words
An adenovirus wherein at least a portion of the adenovirus fiber protein is removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 3
Dependent Claim
26 words
An adenovirus including a fusion protein of an adenovirus fiber protein and a ligand which is specific for a receptor located on a desired cell type.
Claim 4
Dependent Claim
26 words
An adenovirus including a fusion protein of an adenovirus fiber protein and a ligand which is specific for a receptor located on a desired cell type.
Claim 5
Dependent Claim
55 words
The adenovirus of claim 1 wherein said adenovirus fiber protein includes a head portion and a shaft portion, and said portion of the adenovirus fiber protein which is removed and replaced with a ligand which is specific for a receptor found on a desired cell type is at least a portion of the head portion.
Claim 6
Dependent Claim
43 words
The adenovirus of claim 1 wherein said adenovirus is Adenovirus 3, and amino acid residues 132 to 319 of the fiber of adenovirus 3 are removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 7
Dependent Claim
43 words
The adenovirus of claim 1 wherein said adenovirus is Adenovirus 5, and amino acid residues 400 to 581 of the fiber of Adenovirus 5 are removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 8
Dependent Claim
44 words
The adenovirus of claim 1 wherein said adenovirus is Adenovirus 41, and amino acid residues 387 to 563 of the long fiber of Adenovirus 41 are removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 9
Dependent Claim
44 words
The adenovirus of claim 1 wherein said adenovirus is Adenovirus 41, and amino acid residues 231 to 387 of the short fiber of Adenovirus 41 are removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
Claim 10
Dependent Claim
19 words
The adenovirus of claim 1 wherein said ligand is the LDL receptor binding region of the apolipoprotein E molecule.
Claim 11
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is epidermal growth factor.
Claim 12
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is fibroblast growth factor.
Claim 13
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is PDGF.
Claim 14
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is colony stimulating factor.
Claim 15
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is IGF-I.
Claim 16
Dependent Claim
11 words
The adenovirus of claim 1 wherein in said ligand is IGF-II.
Claim 17
Dependent Claim
31 words
The adenovirus of claim 1 wherein said ligand is selected from the group consisting of Interleukin 1,; Interleukin-2; Interleukin-3; Interleukin-4; Interleukin-5; Interleukin-6; Interleukin-7; Interleukin-8; Interleukin-9; Interleukin-10; Interleukin-11; Interleukin-12; Interleukin-13; and Interleukin-14.
Claim 18
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is TNF-alpha.
Claim 19
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is TNF-beta.
Claim 20
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is transferrin.
Claim 21
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is alpha-2-macroglobulin.
Claim 22
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is alpha-1 acid glycoprotein.
Claim 23
Dependent Claim
11 words
The adenovirus of claim 1 wherein said ligand is mannose-containing peptide.
Claim 24
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is sialyl-Lewis-X antigen-containing peptide.
Claim 25
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is a CD34 ligand.
Claim 26
Dependent Claim
12 words
The adenovirus of claim 1 wherein said ligand is a CD40 ligand.
Claim 27
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is ICAM-1.
Claim 28
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is M-CSF.
Claim 29
Dependent Claim
11 words
The adenovirus of claim 1 wherein said ligand is circumsporozoite protein.
Claim 30
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is VLA-4.
Claim 31
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is LFA-1.
Claim 32
Dependent Claim
10 words
The adenovirus of claim 1 wherein said ligand is NGF.
Claim 33
Dependent Claim
11 words
The adenovirus of claim 1 wherein said ligand is HIV gp120.
Claim 34
Dependent Claim
13 words
The adenovirus of claim 1 wherein said ligand is Class II MHC antigen.
Claim 35
Dependent Claim
16 words
The adenovirus of claim 1 wherein said ligand is an Fv antigen-binding domain of an immunoglobulin.
Claim 36
Dependent Claim
37 words
An adenoviral vector wherein DNA encoding a portion of the fiber protein of the adenovirus is removed and is replaced with DNA encoding a ligand which is specific for a receptor located on a desired cell type.
Claim 37
Dependent Claim
37 words
An adenoviral vector wherein DNA encoding a portion of the fiber protein of the adenovirus is removed and is replaced with DNA encoding a ligand which is specific for a receptor located on a desired cell type.
Claim 38
Dependent Claim
34 words
An adenoviral vector including a DNA sequence comprised of DNA encoding an adenovirus fiber protein operatively linked to DNA encoding a ligand which is specific for a receptor located on a desired cell type.
Claim 39
Dependent Claim
34 words
An adenoviral vector including a DNA sequence comprised of DNA encoding an adenovirus fiber protein operatively linked to DNA encoding a ligand which is specific for a receptor located on a desired cell type.
References Cited (Backward Citations)
WO1994010323A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-06 | 2000-02-05 | 2000-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-06 | 2004-02-05 | 2004-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-06 | 2008-02-05 | 2008-08-06 | $7700.00 | Window Closed / Lapsed |