US5534548A
Expired / Lapsed
US
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Method of treating preeclampsia
Assignee: Abbott Laboratories
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Filing: 1994-05-03
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Granted: 1996-07-09
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Expires: 2014-05-03
Abstract
Abstract Straight-chain alkanoic acids, substituted at the Ω-carbon atom by a substituted phenyl, naphthyl, furyl, or thienyl group and by a substituted 1,4-benzoquinon-2-yl group are effective in the therapy or prophylaxis of conditions associated with lipid peroxide injury to vascular endothelium particularly preeclampsia and eclampsia in pregnant females.
Inventors
- 👤 Anthony Killian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 08:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K31/33; A61K31/335; A61K31/34; A61K31/38
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
128 words
A method for the therapy or prophylaxis of preeclampsia and eclampsia in pregnant females comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound selected from the group consisting of compounds having the structural formula ##STR2## wherein n is an integer of from 2 to 10, inclusive; R 1 and R 2 are methyl; and R 4 is selected from the group consisting of unsubstituted phenyl, and phenyl substituted with one or more substituents selected from the group consisting of alkyl of one to three carbon atoms, alkoxy of one to three carbon atoms, and halogen; R 5 is selected from the group consisting of carboxyl alkoxycarbonyl of two to five carbon atoms, and phenoxycarbonyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
128 words
A method for the therapy or prophylaxis of preeclampsia and eclampsia in pregnant females comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound selected from the group consisting of compounds having the structural formula ##STR2## wherein n is an integer of from 2 to 10, inclusive; R 1 and R 2 are methyl; and R 4 is selected from the group consisting of unsubstituted phenyl, and phenyl substituted with one or more substituents selected from the group consisting of alkyl of one to three carbon atoms, alkoxy of one to three carbon atoms, and halogen; R 5 is selected from the group consisting of carboxyl alkoxycarbonyl of two to five carbon atoms, and phenoxycarbonyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein n is 6 or 7.
Claim 4
Dependent Claim
32 words
The method of claim 2 wherein said compound is selected from the group consisting of 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid, 6-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-6-(4-methoxyphenyl)hexanoic acid, 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-(4-methoxyphenyl)heptanoic acid, 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-(4-fluorophenyl)heptanoic acid, and 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-(4-methylphenyl)heptanoic acid; or a pharmaceutically acceptable salt thereof.
Claim 5
Independent Claim
39 words
A method for the therapy or prophylaxis of preeclampsia and eclampsia in a pregnant female woman comprising administering to a patient in need of such treatment a therapeutically effective amount of 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt thereof.
Claim 6
Independent Claim
39 words
A method for the therapy or prophylaxis of preeclampsia and eclampsia in a pregnant female woman comprising administering to a patient in need of such treatment a therapeutically effective amount of 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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