US5525735A
Expired / Lapsed
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Methods for synthesizing diverse collections of pyrrolidine compounds
Assignee: Affymax Technologies NV
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Filing: 1994-12-12
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Granted: 1996-06-11
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Expires: 2014-12-12
Abstract
Abstract Disclosed are methods for synthesizing very large collections of diverse pyrrolidine compounds and derivatives thereof on solid supports and synthetic compound libraries comprising pyrrolidine groups and derivatives thereof prepared by such methods.
Inventors
- 👤 Mark A. Gallop
- 👤 Martin A. Murphy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:58
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00583; B01J2219/00592; B01J2219/00718; B01J2219/0072
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
86 words
A synthetic compound library comprising a plurality of different compounds each compound covalently linked to a solid support wherein each of said compounds comprise at least one pyrrolidinyl group which group is prepared by the method which comprises (a) selecting a solid support comprising at least one compound attached thereto which compound comprises a moiety selected from the group consisting of a complementary group having at least one site of carbon-carbon unsaturation and an azomethine ylide precursor; and (b) converting said moiety to a pyrrolidinyl group.
Claim 2
Dependent Claim
86 words
A synthetic compound library comprising a plurality of different compounds each compound covalently linked to a solid support wherein each of said compounds comprise at least one pyrrolidinyl group which group is prepared by the method which comprises (a) selecting a solid support comprising at least one compound attached thereto which compound comprises a moiety selected from the group consisting of a complementary group having at least one site of carbon-carbon unsaturation and an azomethine ylide precursor; and (b) converting said moiety to a pyrrolidinyl group.
Claim 3
Dependent Claim
25 words
The synthetic compound library according to claim 1 wherein each compound of said plurality of different compounds is covalently linked to the same solid support.
Claim 4
Dependent Claim
25 words
The synthetic compound library according to claim 1 wherein each compound of said plurality of different compounds is covalently linked to a different solid support.
Claim 5
Dependent Claim
31 words
The synthetic compound library according to claim 1 wherein each compound in said library comprises a peptide compound wherein the pyrrolidinyl group is located at any point in the peptide sequence.
Claim 6
Dependent Claim
21 words
The synthetic compound library according to claim 1 wherein each compound in said library comprises a plurality of different pyrrolidinyl compounds.
Claim 7
Dependent Claim
20 words
The synthetic compound library according to claim 1, further comprising the step of: (c) cleaving the compound from the support.
Claim 8
Dependent Claim
22 words
The synthetic compound library according to claim 1, further comprising the step of: (c) treating said pyrrolidinyl group with an acylating reagent.
Claim 9
Dependent Claim
52 words
The synthetic compound library according to claim 7, wherein the acylating reagent comprises a compound having the formula: HSCH.sub.2 CHR.sup.3 C(O)X wherein R 3 is selected from the group consisting of alkyl, alkoxy, carboxyl, carboxyl ester, R 5 --C(O)-- where R 5 is alkyl or aryl and X is bromine or chlorine.
Claim 10
Dependent Claim
19 words
The synthetic compound library according to claim 8, wherein each compound in said library comprises a different mercaptoacyl proline.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-11 | 1999-12-11 | 2000-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-11 | 2003-12-11 | 2004-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-11 | 2007-12-11 | 2008-06-11 | $7700.00 | Window Closed / Lapsed |