US5525646A
Expired / Lapsed
US
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Bioresorbable material and an article of manufacture made of such material for medical use
Assignee: SUNSTAR LAUSANNE SA
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Filing: 1992-03-04
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Granted: 1996-06-11
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Expires: 2012-03-04
Abstract
Abstract This invention relates to a bioresorbable material and an article of manufacture of such material for medical use comprising homopolymers, copolymers, or a blend thereof selected from the group of monomers including glycolic acid, lactic acid, caprolactone, trimethylene carbonate, paradioxanone and 1,5 dioxepan-2-one, a plasticizer selected from the group including ethyl, butyl and hexyl esters of acetylated or non-acetylated citric acid, ethyl terminated oligomers of lactic acid, having no less than 2 and no more than 10 units, and lactic acid esters of glycerol, the material comprises 50% of amorphous polymer or polymers to impart to the material plastic malleability substantially without memory.
Inventors
- 👤 Dan Lundgren
- 👤 Jan Gottlow
- 👤 Torbjorn Mathisen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 10:18
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/141; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/502; A61L31/04; A61L31/06
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
114 words
Bioresorbable material adaptable for medical use comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate, said amorphous polymer comprising at least 50% by weight of said material; at least one crystalline polymer selected from the group consisting of poly-l-lactide, polycaprolactone and polydioxanone; and a plasticizer selected from the group consisting of ethyl, butyl and hexyl esters of acetylated citric acid, and ethyl-terminated oligomers of lactic acid having no less than 2 and no more than 10 units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 2
Dependent Claim
114 words
Bioresorbable material adaptable for medical use comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate, said amorphous polymer comprising at least 50% by weight of said material; at least one crystalline polymer selected from the group consisting of poly-l-lactide, polycaprolactone and polydioxanone; and a plasticizer selected from the group consisting of ethyl, butyl and hexyl esters of acetylated citric acid, and ethyl-terminated oligomers of lactic acid having no less than 2 and no more than 10 units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 3
Dependent Claim
121 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate, said amorphous polymer comprising at least 50% by weight of said material; at least one crystalline polymer selected from the group consisting of poly-l-lactide, polycaprolactone and polydioxanone; and a plasticizer selected from the group consisting of ethyl, butyl and hexyl esters of acetylated citric acid, and ethyl-terminated oligomers of lactic acid having no less than 2 and no more than l units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 4
Dependent Claim
121 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate, said amorphous polymer comprising at least 50% by weight of said material; at least one crystalline polymer selected from the group consisting of poly-l-lactide, polycaprolactone and polydioxanone; and a plasticizer selected from the group consisting of ethyl, butyl and hexyl esters of acetylated citric acid, and ethyl-terminated oligomers of lactic acid having no less than 2 and no more than l units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 5
Dependent Claim
74 words
A bioresorbable material adaptable for medical use comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate; and a plasticizer based on ethyl terminated lactic acid oligomers having no less than 2 and no more than 10 units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 6
Dependent Claim
74 words
A bioresorbable material adaptable for medical use comprising: bioresorbable polymer comprising at least one amorphous polymer or copolymer selected from the group consisting of poly-d,l-lactide, and copolymers of poly-d,l-lactide and polycaprolactone, poly-l-lactide, or polytrimethylene carbonate; and a plasticizer based on ethyl terminated lactic acid oligomers having no less than 2 and no more than 10 units of lactic acid; said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 7
Dependent Claim
22 words
The bioresorbable composition of claim 3, wherein the amount of plasticizer ranges from about 5 to 25% by weight of said composition.
Claim 8
Dependent Claim
21 words
The bioresorbable material of claim 1, wherein said crystalline polymer ranges from about 5 to 40% by weight of said material.
Claim 9
Dependent Claim
23 words
The bioresorbable composition of claim 1, wherein the amount of plasticizer ranges from about 5 to about 25% by weight of said composition.
Claim 10
Dependent Claim
32 words
The bioresorbable material of claim 6, wherein the plasticizer is at least one citrate ester, and the proportion of plasticizer ranges from about 9 to about 17% by weight of said material.
Claim 11
Dependent Claim
49 words
The bioresorbable material of claim 6, wherein said amorphous polymer is selected from at least one of the group consisting of poly-d,l-lactide and copolymers of poly-d-l-lactide and poly-l-lactide, the plasticizer is at least one ethyl-terminated lactic acid oligomer, and said plasticizer comprises about 20% by weight of said material.
Claim 12
Dependent Claim
30 words
The bioresorbable material of claim 6, wherein said material comprises about 76% by weight poly-d,l-lactide, 10% by weight poly-l-lactide as polymers, and 14% by weight acetyltri-n-butyl citrate as said plasticizer.
Claim 13
Dependent Claim
32 words
The bioresorbable material of claim 8, wherein said material comprises about 75% by weight poly-d, l-lactide and 10% by weight polycaprolactone as polymers, and 15% by weight acetyltri-n-butyl citrate as said plasticizer.
Claim 14
Dependent Claim
30 words
The bioresorbable material of claim 4, wherein said material comprises about 80% by weight poly-d,l-lactide, and 20% by weight of at least one ethyl-terminated oligomer of lactic acid as plasticizer.
Claim 15
Dependent Claim
20 words
The article of claim 2, wherein said crystaline polymer ranges from about 5 to 40% by weight of said material.
Claim 16
Dependent Claim
23 words
The article of claim 2, wherein the amount of plasticizer ranges from about 5 to about 25% by weight of the bioresorbable material.
Claim 17
Dependent Claim
60 words
The article of claim 13, wherein said amorphous polymer is selected from at least one of the group consisting of poly-d-l-lactide and copolymers of poly-d,l-lactide and poly-l-lactide, based on polylactic acid and said plasticizer is at least one citrate ester, and that the proportion of plasticizer ranges from about 9 to about 17% by weight of the said bioresorbable material.
Claim 18
Dependent Claim
50 words
The article of claim 13, wherein said amorphous polymer is selected from at least one of the group consisting of poly-d,l-lactide and copolymers of poly-d-l-lactide and poly-l-lactide, the plasticizer is at least one ethyl-terminated lactic acid oligomer and said plasticizer amounts to about 20% by weight of said bioresorbable material.
Claim 19
Dependent Claim
31 words
The article of claim 13, wherein said bioresorbable material comprises about 76% by weight poly-d,l-lactide and 10% by weight poly-l-lactide as polymers, and 14% by weight acetyltri-n-butyl citrate as said plasticizer.
Claim 20
Dependent Claim
17 words
The article of claim 2, wherein said article comprises a medical device comprising apertures formed by perforating.
Claim 21
Dependent Claim
55 words
Bioresorbable material adaptable for medical use comprising a bioresorbable polymer comprising about 75% by weight of said material of amorphous poly-d,l-lactide, and about 10% by weight of polycaprolactone, as polymers, and about 15% by weight acetyltri-n-butyl citrate as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 22
Dependent Claim
55 words
Bioresorbable material adaptable for medical use comprising a bioresorbable polymer comprising about 75% by weight of said material of amorphous poly-d,l-lactide, and about 10% by weight of polycaprolactone, as polymers, and about 15% by weight acetyltri-n-butyl citrate as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 23
Dependent Claim
54 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising about 75% by weight amorphous poly-d,l-lactide and about 10% by weight of polycaprolactone as polymers, and about 15% by weight acetyltri-n-butyl citrate as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 24
Dependent Claim
54 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising about 75% by weight amorphous poly-d,l-lactide and about 10% by weight of polycaprolactone as polymers, and about 15% by weight acetyltri-n-butyl citrate as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 25
Dependent Claim
52 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising about 80% by weight amorphous poly-d,l-lactide, and about 20% by weight of at least one ethyl-terminated oligomer of lactic acid as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 26
Dependent Claim
52 words
An article of manufacture adaptable for medical use made from a bioresorbable material comprising about 80% by weight amorphous poly-d,l-lactide, and about 20% by weight of at least one ethyl-terminated oligomer of lactic acid as a plasticizer, said material being characterized by having plastic malleability substantially without memory combined with low swelling.
Claim 27
Dependent Claim
28 words
The article of claim 19 wherein said article comprises a medical device comprising apertures formed by perforating, wherein said apertures have a minimum transverse dimension of 10 μm.
Claim 28
Dependent Claim
16 words
The article of claim 21 wherein the total area of said apertures is at least 6%.
Claim 29
Dependent Claim
24 words
The article of claim 21, wherein said apertures are spaced at a center to center distance ranging from about 700 μm to 150 μm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-11 | 1999-12-11 | 2000-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-11 | 2003-12-11 | 2004-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-11 | 2007-12-11 | 2008-06-11 | $7700.00 | Window Closed / Lapsed |