US5515859A — Myocardial infarction and ischemia detection meth…

Claim 1

Independent Claim 113 words

A device for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber adapted to receive and contain the patient's expired breath; a light source positioned to shine a light into the sample chamber; a first light detector positioned to detect the light at a first predetermined frequency after it has traversed the sample chamber, the first light detector providing a first signal corresponding to the intensity of the light detected at said first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and indicator means, responsive to the first signal, for providing an indication of the value of the first signal.

Claim 2

Independent Claim 113 words

A device for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber adapted to receive and contain the patient's expired breath; a light source positioned to shine a light into the sample chamber; a first light detector positioned to detect the light at a first predetermined frequency after it has traversed the sample chamber, the first light detector providing a first signal corresponding to the intensity of the light detected at said first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and indicator means, responsive to the first signal, for providing an indication of the value of the first signal.

Claim 3

Dependent Claim 12 words

The device of claim 1, wherein said light source shines infrared light.

Claim 4

Dependent Claim 62 words

The device of claim 2, further comprising a second light detector positioned to detect the light at a second predetermined frequency after it has traversed the sample chamber, the second light detector providing a second signal corresponding to the intensity of the light detected at said second predetermined frequency, where the second predetermined frequency corresponds to a second absorption band of adenosine.

Claim 5

Dependent Claim 36 words

The device of claim 3, wherein at least one of said light detectors comprises an optical bandpass filter and a photodetector arranged such that the light travels through said optical bandpass filter before striking said photodetector.

Claim 6

Dependent Claim 27 words

The device of claim 4, wherein said optical bandpass filter has a center frequency of 1300 cm -1 wavenumbers which corresponds to an absorption band of adenosine.

Claim 7

Dependent Claim 27 words

The device of claim 4, wherein said optical bandpass filter has a center frequency of 1580 cm -1 wavenumbers which corresponds to an absorption band of adenosine.

Claim 8

Dependent Claim 27 words

The device of claim 4, wherein said optical bandpass filter has a center frequency of 1610 cm -1 wavenumbers which corresponds to an absorption band of adenosine.

Claim 9

Dependent Claim 27 words

The device of claim 4, wherein said optical bandpass filter has a center frequency of 2880 cm -1 wavenumbers which corresponds to an absorption band of adenosine.

Claim 10

Dependent Claim 109 words

The device of claim 1, further comprising a reference chamber to receive and contain a reference gas, wherein said light source is positioned to shine said light into said reference chamber, and further comprising a reference light detector positioned to detect said light at said first predetermined frequency after it has traversed said reference chamber, said reference light detector providing a reference signal corresponding to an intensity of said light detected at the first predetermined frequency and wherein said indicator means comprises means responsive to the reference signal for providing an indication of the difference between the value of the first signal and the value of the reference signal.

Claim 11

Independent Claim 73 words

A method for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, the method comprising: containing the breath; shining a light through the breath; detecting the light after it has passed though the breath; providing a first signal corresponding to an intensity of the light detected at a first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and indicating the value of the signal.

Claim 12

Independent Claim 73 words

A method for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, the method comprising: containing the breath; shining a light through the breath; detecting the light after it has passed though the breath; providing a first signal corresponding to an intensity of the light detected at a first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and indicating the value of the signal.

Claim 13

Dependent Claim 16 words

The method of claim 10, wherein the shining step includes shining light in the infrared range.

Claim 14

Dependent Claim 36 words

The method of claim 10, further comprising providing a signal corresponding to the intensity of the light detected at a second predetermined frequency, where the second predetermined frequency corresponds to a second absorption band of adenosine.

Claim 15

Dependent Claim 20 words

The method of claim 10 further including providing a reference signal and comparing the reference signal to the first signal.

Claim 16

Independent Claim 60 words

A device for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the adenosine; and display mean operatively coupled to said analyzing means to provide an output correlative to the existence of the adenosine.

Claim 17

Independent Claim 60 words

A device for detecting adenosine in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the adenosine; and display mean operatively coupled to said analyzing means to provide an output correlative to the existence of the adenosine.

Claim 18

Dependent Claim 49 words

The device of claim 14 further comprising means to initialize said device including reference means for receiving an exemplar having initializing qualities, said reference means coupled to said analyzing means and comparing means coupled to said analyzing means to receive data therefrom whereby said device will have been initialized.

Claim 19

Dependent Claim 30 words

The device of claim 15 wherein said analyzing means includes plural sensors, each said sensor tuned to a different characteristic of adenosine to render less likely a false positive reading.

Claim 20

Dependent Claim 53 words

The device of claim 16 further including means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit, whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

Claim 21

Independent Claim 24 words

A method for diagnosing cardiovascular distress, the steps including: sampling expired breath; analyzing the breath for adenosine; and displaying results of the analyzing step.

Claim 22

Independent Claim 24 words

A method for diagnosing cardiovascular distress, the steps including: sampling expired breath; analyzing the breath for adenosine; and displaying results of the analyzing step.

Claim 23

Independent Claim 42 words

A method for diagnosing cardiovascular distress, the steps including: sampling expired breath; analyzing the breath for a telltale correlative of the distress; and displaying results of the analyzing step, including initializing the diagnostic procedure by comparing the breath with a known reference.

Claim 24

Independent Claim 42 words

A method for diagnosing cardiovascular distress, the steps including: sampling expired breath; analyzing the breath for a telltale correlative of the distress; and displaying results of the analyzing step, including initializing the diagnostic procedure by comparing the breath with a known reference.

Claim 25

Dependent Claim 25 words

The method of claim 19 including sensing the expired breath with multiple sensors, thereby providing multiple characteristics of the expired breath to minimize false positives.

Claim 26

Independent Claim 173 words

A device for detecting a substance in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the substance; display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance; means to initialize said device including reference means for receiving an exemplar having initializing qualities; said reference means coupled to said analyzing means; comparing means coupled to said analyzing means to receive data therefrom whereby said device will have been initialized; said analyzing means including plural sensors, each said sensor tuned to a different characteristic of the substance to render less likely a false positive reading; and means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

Claim 27

Independent Claim 173 words

A device for detecting a substance in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the substance; display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance; means to initialize said device including reference means for receiving an exemplar having initializing qualities; said reference means coupled to said analyzing means; comparing means coupled to said analyzing means to receive data therefrom whereby said device will have been initialized; said analyzing means including plural sensors, each said sensor tuned to a different characteristic of the substance to render less likely a false positive reading; and means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

Claim 28

Independent Claim 112 words

A device for detecting a substance in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the substance; display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance; means to initialize said detector; and means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit, whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

Claim 29

Independent Claim 112 words

A device for detecting a substance in a patient's expired breath indicative of cardiovascular distress, comprising: a sample chamber to receive and contain the breath; means for analyzing the breath contained within said sample chamber for the existence of the substance; display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance; means to initialize said detector; and means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit, whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

Claim 30

Independent Claim 133 words

A method for determining the concentration of adenosine in a patient's expired breath indicative of cardiovascular distress, the steps including: containing a sample of expired breath from the patient; shining a light through the sample of expired breath; detecting and recording the light intensity before it has passed through the sample of expired breath; detecting and recording the light intensity after it has passed through the sample of expired breath; calculating the concentration of adenosine by utilizing the formula: ##EQU3## where C is the concentration of adenosine, I O is the light intensity before the light has passed through the sample of expired breath, I F is the light intensity after the light has passed through the sample of expired breath, a is the absorption constant, and b is the absorption path length.

Claim 31

Independent Claim 133 words

A method for determining the concentration of adenosine in a patient's expired breath indicative of cardiovascular distress, the steps including: containing a sample of expired breath from the patient; shining a light through the sample of expired breath; detecting and recording the light intensity before it has passed through the sample of expired breath; detecting and recording the light intensity after it has passed through the sample of expired breath; calculating the concentration of adenosine by utilizing the formula: ##EQU3## where C is the concentration of adenosine, I O is the light intensity before the light has passed through the sample of expired breath, I F is the light intensity after the light has passed through the sample of expired breath, a is the absorption constant, and b is the absorption path length.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1999-05-14	1999-11-13	2000-05-14	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2003-05-14	2003-11-13	2004-05-14	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2007-05-14	2007-11-13	2008-05-14	$7700.00	Window Closed / Lapsed

Myocardial infarction and ischemia detection method and apparatus

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