US5514374A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cosmetic or pharmaceutical composition containing a black horehound extract
Assignee: LVMH Recherche GIE
•
Filing: 1992-11-27
•
Granted: 1996-05-07
•
Expires: 2012-11-27
Abstract
Abstract PCT No. PCT/FR92/01105 Sec. 371 Date May 27, 1994 Sec. 102(e) Date May 27, 1994 PCT Filed Nov. 27, 1992 PCT Pub. No. WO93/10804 PCT Pub. Date Jun. 10, 1993.A black horehound extract is used to prepare a cosmetic or pharmaceutical composition, particularly a dermatological composition, for promoting skin pigmentation, preventing or delaying the growth of grey hairs, treating pigmentary disorders, reducing triglyceride levels in fat cells, and preventing the build-up of body fat such as in cellulite. The composition may particularly be used effectively to promote skin or hair pigmentation and a reduction in the build-up of body fat such as in cellulite.
Inventors
- 👤 Frederic Bonte
- 👤 Alain Meybeck
- 👤 Marc Dumas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:01
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/06; A61K; A61K36/00; A61K36/18; A61K36/185; A61K36/53; A61K8/00; A61K8/18; A61K8/96; A61K8/97; A61K8/9783; A61K8/9789; A61P; A61P17/00; A61P3/00; A61P3/06; A61Q19/04; A61Q5/00; A61Q5/06; A61Q5/065; A61Q5/10
Claims Analysis
Total Claims: 68
Claim 1
Independent Claim
117 words
A method of promoting pigmentation of skin or hair, comprising applying to areas of the skin, scalp or hair of a person in need thereof, an effective amount of at least one solvent extract of black horehound to increase the pigmentation of said areas, to restore normal pigmentation of said areas or to prevent or slow down the appearance of white or grey hair said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and super-critical carbon dioxide gas.
Claim 2
Independent Claim
117 words
A method of promoting pigmentation of skin or hair, comprising applying to areas of the skin, scalp or hair of a person in need thereof, an effective amount of at least one solvent extract of black horehound to increase the pigmentation of said areas, to restore normal pigmentation of said areas or to prevent or slow down the appearance of white or grey hair said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and super-critical carbon dioxide gas.
Claim 3
Dependent Claim
23 words
The method of claim 1, wherein said black horehound is selected from the group consisting of Ballota nigra, Ballota lanata and Ballota suavelens.
Claim 4
Dependent Claim
43 words
The method of claim 1, wherein said extract of black horehound is an extract selected from the group consisting of an extract of the whole plant, an extract of the aerial part, an extract of the stem, and an extract of the leaves.
Claim 5
Dependent Claim
61 words
The method of claim 1, wherein said extract of black horehound is an extract obtained by at least one extraction step with an organic solvent selected from the group consisting of an alcohol, from 1 to 4 carbon atoms, a water/alcohol admixture, a chlorinated solvent from 1 to 2 carbon atoms, and an organic ester from 3 to 6 carbon atoms.
Claim 6
Dependent Claim
19 words
The method of claim 4, wherein said alcohol is selected from the group consisting of methanol, ethanol and propanol.
Claim 7
Dependent Claim
19 words
The method of claim 4, wherein said chlorinated solvent is selected from the group consisting of chloroform and dichloromethane.
Claim 8
Dependent Claim
11 words
The method of claim 4, wherein said organic ester is ethylacetate.
Claim 9
Dependent Claim
35 words
The method of claim 1, wherein said extract of black horehound is applied at a concentration, expressed by dry weight, ranging between 0.0001% and 5% by weight, based on the total weight of the composition.
Claim 10
Dependent Claim
35 words
The method of claim 1, wherein said extract of black horehound is applied at a concentration, expressed by dry weight, ranging between 0.01% and 0.5% by weight, based on the total weight of the composition.
Claim 11
Dependent Claim
20 words
The method of claim 1, wherein said extract of black horehound is present in a composition further comprising a xanthine.
Claim 12
Dependent Claim
20 words
The method of claim 10, wherein said xanthine is selected from the group consisting of 1-methylxanthine, 3-methylxanthine, 3-isobutylmethylxanthine and theophylline.
Claim 13
Dependent Claim
28 words
The method of claim 10, wherein said xanthine is present at a concentration ranging between 0.001% and 2% by weight, based on the total weight of the composition.
Claim 14
Dependent Claim
28 words
The method of claim 10, wherein said xanthine is present at a concentration ranging between 0.01% and 0.5% by weight, based on the total weight of the composition.
Claim 15
Dependent Claim
33 words
The method of claim 1, wherein said extract of black horehound is present in a composition further comprising a tyrosine component selected from the group consisting of tyrosine N-malyltyrosine and a tyrosine ester.
Claim 16
Dependent Claim
28 words
The method of claim 14, wherein said tyrosine component is at a concentration ranging between 0.001% and 10% by weight, based on the total weight of the composition.
Claim 17
Dependent Claim
12 words
The method of claim 14, wherein said tyrosine ester is glucose tyrosinate.
Claim 18
Dependent Claim
60 words
The method of claim 1, wherein said extract of black horehound is present in a composition further comprising another active substance selected from the group consisting of vitamins, quinine, rubefacients, a papilla fibroblast culture supernatant, a keratin hydrolyzate; a trace element, a 5-α-reductase element, a 5-αreductase inhibitor, cyproterone acetate, minoxidil, azelaic acid, a 1,4-methyl-4-azasteroid, and an extract of Serenoa repens.
Claim 19
Dependent Claim
15 words
The method of claim 17, wherein said vitamin is belonging to the B vitamin group.
Claim 20
Dependent Claim
10 words
The method of claim 17, wherein said rubefacient is methylnicotinate.
Claim 21
Dependent Claim
20 words
The method of claim 17, wherein said trace element is selected from the group consisting of zinc, selenium and copper.
Claim 22
Dependent Claim
11 words
The method of claim 17, wherein said 5-α-reductase inhibitor is progesterone.
Claim 23
Dependent Claim
10 words
The method of claim 17, wherein said 1,4-methyl-4-azasteroid is 17-β-N,N-diethylcarbamoyl-4-methyl-4-aza-5-α-androstan-3-one.
Claim 24
Dependent Claim
40 words
The method of claim 1, wherein said extract of black horehound is present in a composition further comprising at least one active substance selected from the group consisting of a xanthine, an extract of ivy and an extract of Coleus.
Claim 25
Dependent Claim
10 words
The method of claim 23, wherein said xanthine is caffeine.
Claim 26
Dependent Claim
16 words
The method of claim 23, wherein said extract of Coleus is an extract of Coleus forskohlii.
Claim 27
Dependent Claim
32 words
The method of claim 1, wherein said extract of black horehound is applied topically and is present in a composition further comprising an agent promoting penetration and diffusion in the skin structure.
Claim 28
Dependent Claim
34 words
The method of claim 26, wherein said agent promoting penetration and diffusion in the skin structure is selected from the group consisting of ethyl alcohol, a glycol, oleic acid, laurocapram and an essential oil.
Claim 29
Dependent Claim
19 words
The method of claim 27, wherein said glycol is selected from the group consisting of glycerol and propylene glycol.
Claim 30
Dependent Claim
19 words
The method of claim 27, wherein said essential oil is selected from the group consisting of menthol and eucalyptol.
Claim 31
Dependent Claim
32 words
The method of claim 1, wherein said extract of black horehound is applied topically and is present in a composition further comprising an agent promoting penetration and diffusion in the skin structure.
Claim 32
Dependent Claim
34 words
The method of claim 30, wherein said agent promoting penetration and diffusion in the skin structure is selected from the group consisting of ethyl alcohol, a glycol, oleic acid, laurocapram and an essential oil.
Claim 33
Dependent Claim
19 words
The method of claim 31, wherein said glycol is selected from the group consisting of glycerol and propylene glycol.
Claim 34
Dependent Claim
19 words
The method of claim 27, wherein said essential oil is selected from the group consisting of methanol and eucalyptol.
Claim 35
Dependent Claim
24 words
The method of claim 1, wherein said extract of black horehound is present in a composition further comprising hydrated lipidic lamellar phases or liposomes.
Claim 36
Dependent Claim
99 words
A pharmaceutical or cosmetic composition formulated for topical administration to the skin, scalp or hair, comprising a pharmaceutically or cosmetically effective amount of a solvent extract of black horehound in a pharmaceutically or cosmetically acceptable excipient adapted for said topical administration to the skin or scalp, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 37
Dependent Claim
99 words
A pharmaceutical or cosmetic composition formulated for topical administration to the skin, scalp or hair, comprising a pharmaceutically or cosmetically effective amount of a solvent extract of black horehound in a pharmaceutically or cosmetically acceptable excipient adapted for said topical administration to the skin or scalp, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 38
Dependent Claim
23 words
The composition of claim 35, wherein the black horehound is selected from the group consisting of Ballota nigra, Ballota lanata and Ballota suavelens.
Claim 39
Dependent Claim
41 words
The composition of claim 35, wherein said extract of black horehound is selected from the group consisting of an extract of the whole plant, an extract of the aerial part, an extract of the stem and an extract of the leaves.
Claim 40
Dependent Claim
61 words
The composition of claim 35, wherein said extract of black horehound is an extract obtained by at least one extraction step with an organic solvent selected from the group consisting of an alcohol from 1 to 4 carbon atoms, a water/alcohol admixture, a chlorinated solvent from 1 to 2 carbon atoms, and an organic ester from 3 to 6 carbon atoms.
Claim 41
Dependent Claim
38 words
The composition of claim 35, wherein said extract of black horehound is present in a composition at a concentration, expressed by dry weight, ranging between 0.0001% and 5% by weight, based on the total weight of the composition.
Claim 42
Dependent Claim
38 words
The composition of claim 35, wherein said extract of black horehound is present in a composition at a concentration, expressed by dry weight, ranging between 0.01% and 0.5% by weight, based on the total weight of the composition.
Claim 43
Dependent Claim
59 words
The composition of claim 35, further comprising at least another active substance selected from the group consisting of a xanthine, a tyrosine component, an extract of ivy, an extract of Coleus, vitamins, quinine, rubefacients, a papilla fibroblast culture supernatant, a keratin hydrolyzate; trace elements, 5-α-reductase inhibitors, cyproterone acetate, minoxidil, azelaic acid, a 1,4-methyl-4-azasteroid, and an extract of Serenoa repens.
Claim 44
Dependent Claim
21 words
The composition of claim 41, wherein said xanthine is selected from the group consisting of 1-methylxanthine, 3-methylxanthine, 3-isobutylmethylxanthine, theophylline and caffeine.
Claim 45
Dependent Claim
21 words
The composition of claim 41, further comprising a tyrosine component selected from the group consisting of tyrosine, N-malyltyrosine and tyrosine ester.
Claim 46
Dependent Claim
29 words
The composition of claim 43, wherein said tyrosine component is present at a concentration ranging between 0.001% and 10% by weight, based on the total weight of the composition.
Claim 47
Dependent Claim
14 words
The composition of claim 41, wherein said vitamin belongs to the B vitamin group.
Claim 48
Dependent Claim
11 words
The composition of claim 41, wherein said rubefacient is methyl nicotinate.
Claim 49
Dependent Claim
20 words
The method of claim 41, wherein said trace element is selected from the group consisting of zinc, selenium and copper.
Claim 50
Dependent Claim
11 words
The composition of claim 41, wherein said 5-α-reductase inhibitor is progesterone.
Claim 51
Dependent Claim
10 words
The composition of claim 41, wherein said 1,4-methyl-4-azasteroid is 17-β-N,N-diethylcarbamoyl-4-methyl-4-aza-5-α-androstan-3-one.
Claim 52
Dependent Claim
16 words
The composition of claim 41, wherein said extract of Coleus is an extract of Coleus forskohlii.
Claim 53
Dependent Claim
17 words
The composition of claim 35, further comprising an agent promoting penetration and diffusion in the skin structures.
Claim 54
Dependent Claim
30 words
The composition of claim 51, wherein said agent promoting penetration and diffusion is selected from the group consisting of ethyl alcohol, a glycol, oleic acid, laurocapram and an essential oil.
Claim 55
Dependent Claim
13 words
The composition of claim 52, wherein said glycol is glycerol or propylene glycol.
Claim 56
Dependent Claim
13 words
The composition of claim 52, wherein said essential oil is menthol or eucalyptol.
Claim 57
Dependent Claim
28 words
The composition of claim 44, wherein said xanthine is present at a concentration ranging between 0.001% and 2% by weight, based on the total weight of the composition.
Claim 58
Dependent Claim
25 words
The composition of claim 35, wherein said topical composition is selected from the group consisting of a cream, a gel, a milk and a lotion.
Claim 59
Dependent Claim
13 words
The composition of claim 35, further comprising hydrated lipidic lamellar phases and liposomes.
Claim 60
Dependent Claim
100 words
A composition comprising 0.001% to 5% by weight, expressed by dry weight, based on the total weight of the composition, of a solvent extract of black horehound admixed with an excipient which is adapted for a topical administration of said composition to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and super-critical carbon dioxide gas.
Claim 61
Dependent Claim
100 words
A composition comprising 0.001% to 5% by weight, expressed by dry weight, based on the total weight of the composition, of a solvent extract of black horehound admixed with an excipient which is adapted for a topical administration of said composition to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and super-critical carbon dioxide gas.
Claim 62
Dependent Claim
23 words
The composition of claim 58, wherein the black horehound is selected from the group consisting of Ballota nigra, Ballota lanata and Ballota suavelens.
Claim 63
Dependent Claim
96 words
A composition comprising from 0.01% to 5% by weight, expressed by dry weight based on the total weight of the composition of a solvent extract of black horehound admixed with an excipient formulated for a topical administration to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 64
Dependent Claim
96 words
A composition comprising from 0.01% to 5% by weight, expressed by dry weight based on the total weight of the composition of a solvent extract of black horehound admixed with an excipient formulated for a topical administration to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 65
Dependent Claim
96 words
A composition comprising from 0.01% to 0.5% by weight, expressed by dry weight based on the total weight of the composition of a solvent extract of black horehound admixed with an excipient formulated for a topical administration to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 66
Dependent Claim
96 words
A composition comprising from 0.01% to 0.5% by weight, expressed by dry weight based on the total weight of the composition of a solvent extract of black horehound admixed with an excipient formulated for a topical administration to the skin, scalp or hair, said solvent being selected from the group consisting of an alcohol, an alcohol-water mixture, a C 1 -C 2 chlorinated solvent, an organic ester, an aromatic hydrocarbon, an halogenated aliphatic hydrocarbon, an halogenated aromatic hydrocarbon, a dialkylether, a dialkyl ketone, a carboxylic acid, dimethylformamide, dioxane, tetrahydrofuran, dimethyl sulfoxide and supercritical carbon dioxide gas.
Claim 67
Dependent Claim
53 words
A cosmetic composition for promoting pigmentation of the skin or hair of a person, formulated for topical administration to the skin, scalp or hair, comprising a pigmenting effective amount of at least one solvent extract of black horehound in a cosmetically acceptable excipient adapted for topical application to the skin, scalp or hair.
Claim 68
Dependent Claim
53 words
A cosmetic composition for promoting pigmentation of the skin or hair of a person, formulated for topical administration to the skin, scalp or hair, comprising a pigmenting effective amount of at least one solvent extract of black horehound in a cosmetically acceptable excipient adapted for topical application to the skin, scalp or hair.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-07 | 1999-11-06 | 2000-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-07 | 2003-11-06 | 2004-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-07 | 2007-11-06 | 2008-05-07 | $7700.00 | Window Closed / Lapsed |