Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
92 words
A compound having the following formula: ##STR7## wherein R is a bivalent radical derived from an acyclic or cyclic hydrocarbon by removal of one hydrogen atom from each of two different carbon atoms; R' is hydrogen or lower alkyl, and wherein X is hydrogen (--H), halo, trifluoromethyl (--CF 3 ), cyano (--CN), or methylsulfoxide (--SOCH 3 ); and wherein, in its acyclic form, R contains at least three and no more than 12 carbon atoms, and in its cyclic form, R contains at least three and no more than eight carbon atoms.
Claim 2
Dependent Claim
92 words
A compound having the following formula: ##STR7## wherein R is a bivalent radical derived from an acyclic or cyclic hydrocarbon by removal of one hydrogen atom from each of two different carbon atoms; R' is hydrogen or lower alkyl, and wherein X is hydrogen (--H), halo, trifluoromethyl (--CF 3 ), cyano (--CN), or methylsulfoxide (--SOCH 3 ); and wherein, in its acyclic form, R contains at least three and no more than 12 carbon atoms, and in its cyclic form, R contains at least three and no more than eight carbon atoms.
Claim 3
Dependent Claim
91 words
A compound of the following formula: ##STR8## wherein R is selected from the group consisting of CH 2 CH(CH 3 ), (CH 2 ) 3 , (CH 2 ) 4 , (CH 2 ) 5 , (CH 2 ) 3 CH(CH 3 )CH 2 , (CH 2 ) 6 , (CH 2 ) 7 , (CH 2 ) 8 , (CH 2 ) 9 , CH 2 ) 10 , (CH 2 ) 11 , and (CH 2 ) 12 , and between C1 and C4 lower alkyl substituted derivatives thereof.
Claim 4
Dependent Claim
91 words
A compound of the following formula: ##STR8## wherein R is selected from the group consisting of CH 2 CH(CH 3 ), (CH 2 ) 3 , (CH 2 ) 4 , (CH 2 ) 5 , (CH 2 ) 3 CH(CH 3 )CH 2 , (CH 2 ) 6 , (CH 2 ) 7 , (CH 2 ) 8 , (CH 2 ) 9 , CH 2 ) 10 , (CH 2 ) 11 , and (CH 2 ) 12 , and between C1 and C4 lower alkyl substituted derivatives thereof.
Claim 5
Dependent Claim
39 words
A compound of the following formula: ##STR9## wherein X is hydrogen (--H), fluoro (--F), chloro (--Cl), bromo (--Br), trifluoromethyl (--CF 3 ), cyano (--CN), or methylsulfoxide (--SOCH 3 ) and n is a whole integer from 1 through 6.
Claim 6
Dependent Claim
39 words
A compound of the following formula: ##STR9## wherein X is hydrogen (--H), fluoro (--F), chloro (--Cl), bromo (--Br), trifluoromethyl (--CF 3 ), cyano (--CN), or methylsulfoxide (--SOCH 3 ) and n is a whole integer from 1 through 6.
Claim 7
Dependent Claim
13 words
The compound of claim 3 wherein n is 4 and X is chloro.
Claim 8
Dependent Claim
13 words
The compound of claim 2 wherein R is CH 2 CH(CH 3 ).
Claim 9
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 3 .
Claim 10
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 4 .
Claim 11
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 5 .
Claim 12
Dependent Claim
17 words
The compound of claim 2 wherein R is (CH 2 ) 3 CH(CH 3 )CH 2 .
Claim 13
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 6 .
Claim 14
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 7 .
Claim 15
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 8 .
Claim 16
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 9 .
Claim 17
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 10 .
Claim 18
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 11 .
Claim 19
Dependent Claim
13 words
The compound of claim 2 wherein R is (CH 2 ) 12 .
Claim 20
Dependent Claim
19 words
An anti-malaria composition containing an effective amount of ±-Trans-N 1 , N 2 -Bis(7-chloroquinolin-4-yl)-cyclohexane-1,2-diamine in a pharmaceutically acceptable carrier.
Claim 21
Dependent Claim
19 words
An anti-malaria composition containing an effective amount of ±-Trans-N 1 , N 2 -Bis(7-chloroquinolin-4-yl)-cyclohexane-1,2-diamine in a pharmaceutically acceptable carrier.
Claim 22
Independent Claim
35 words
A method for the treatment of malaria comprising administering to a host an N,N-bis(7-substituted-quinolin-4-yl)alkane diamine of claims 1-17 in a pharmaceutically acceptable carrier containing an amount of said diamine which is effective in treating malaria.
Claim 23
Dependent Claim
35 words
The method of claim 18 wherein the effective dose for treating malaria is that dose which is toxic to the malaria parasite infecting the host, but below the threshold of significant toxicity to the host.
Claim 24
Dependent Claim
14 words
An antimalarial composition comprising the compounds of claims 1-17 in a pharmaceutically acceptable carrier.