US5507785A
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US
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Rate responsive cardiac pacemaker with biphasic impedance sensing and method
Assignee: INTERMEIDCS Inc
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Filing: 1994-12-21
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Granted: 1996-04-16
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Expires: 2014-12-21
Abstract
Abstract An implantable, rate responsive pacemaker, sensitive to impedance changes in the heart as an indicator of cardiac stroke volume or minute volume, wherein common interfering signals such as the intracardiac electrogram, myoelectric signals, pacing artifacts and other pacing after potentials are reduced or eliminated from the measurement of the impedance by the use of a biphasic test signal. The cardiac pacemaker has a signal injector which produces biphasic test pulses of similar duration and magnitude and of constant current, though of opposite polarity. The pacemaker also has a detector which senses voltage resulting from the applied biphasic current pulses in each phase. Since the injector and detector are separate circuits, they can be used with a variety of electrode configurations.
Inventors
- 👤 Don C. Deno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:39
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/365; A61N1/36514; A61N1/36521
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
178 words
A cardiac stimulation apparatus comprising means for stimulating a patient's heart; means for measuring impedance within the patient's body, said impedance measuring means including means for producing a constant current biphasic pulse pair, said pulse pair having a first pulse having current flowing in a first direction and a second pulse having current flowing in a second direction, means for electrically transmitting said pulse pair through at least a portion of said patient's body, means for detecting a first voltage associated with said first pulse across at least a part of said patient's body, means for producing a first signal proportional to said first voltage, means for detecting a second voltage associated with said second pulse across at least a part of said patient's body, means for producing a second signal proportional to said second voltage, and means for producing a combined signal from said first and second signals, means for deriving a metabolic demand parameter from said combined signal; and means for adjusting said means for stimulating said patient's heart in relation to said metabolic demand parameter.
Claim 2
Dependent Claim
178 words
A cardiac stimulation apparatus comprising means for stimulating a patient's heart; means for measuring impedance within the patient's body, said impedance measuring means including means for producing a constant current biphasic pulse pair, said pulse pair having a first pulse having current flowing in a first direction and a second pulse having current flowing in a second direction, means for electrically transmitting said pulse pair through at least a portion of said patient's body, means for detecting a first voltage associated with said first pulse across at least a part of said patient's body, means for producing a first signal proportional to said first voltage, means for detecting a second voltage associated with said second pulse across at least a part of said patient's body, means for producing a second signal proportional to said second voltage, and means for producing a combined signal from said first and second signals, means for deriving a metabolic demand parameter from said combined signal; and means for adjusting said means for stimulating said patient's heart in relation to said metabolic demand parameter.
Claim 3
Dependent Claim
27 words
The cardiac stimulation apparatus according to claim 1 wherein said means for producing a constant current biphasic pair comprise means for producing a plurality of biphasic pairs.
Claim 4
Dependent Claim
27 words
The cardiac stimulation apparatus according to claim 1 wherein said means for producing a combined signal comprise means for subtracting said second signal from said first signal.
Claim 5
Dependent Claim
48 words
The cardiac stimulation apparatus according to claim 3 wherein said means for subtracting said second signal from said first signal comprise a first capacitor for storing said first voltage, a second capacitor for storing said second voltage, and means for connecting said first and second capacitors in series.
Claim 6
Dependent Claim
133 words
The cardiac stimulation apparatus according to claim 4 wherein said means for electrically transmitting said pulse pair comprise a first electrode and a second electrode and wherein said means for producing said biphasic constant current pulse pair comprise a constant current source having a first electrical pole and a second electrical pole, a first switch for connecting said first electric pole to said first electrode during a first selected period of time, a second switch for connecting said second electric pole to said second electrode during said first selected period of time, a third switch for connecting said first electric pole to said second electrode during a second selected period of time, and a fourth switch for connecting said second electric pole to said first electrode during said second selected period of time.
Claim 7
Dependent Claim
47 words
The cardiac stimulation apparatus according to claim 5 wherein said constant current source comprises a source of electrical power, a capacitor electrically connected to said source of power, and a resistor electrically connected in series to said capacitor and to said first switch and said third switch.
Claim 8
Dependent Claim
133 words
The cardiac stimulation apparatus according to claim 1 wherein said means for electrically transmitting said pulse pair comprise a first electrode and a second electrode and wherein said means for producing said biphasic constant current pulse pair comprise a constant current source having a first electrical pole and a second electrical pole, a first switch for connecting said first electric pole to said first electrode during a first selected period of time, a second switch for connecting said second electric pole to said second electrode during said first selected period of time, a third switch for connecting said first electric pole to said second electrode during a second selected period of time, and a fourth switch for connecting said second electric pole to said first electrode during said second selected period of time.
Claim 9
Dependent Claim
47 words
The cardiac stimulation apparatus according to claim 7 wherein said constant current source comprises a source of electrical power, a capacitor electrically connected to said source of power, and a resistor electrically connected in series to said capacitor and to said first switch and said third switch.
Claim 10
Dependent Claim
35 words
The cardiac stimulation apparatus according to claim 8 wherein said first pulse has a first current amplitude and said second pulse has a second current amplitude and said first and second amplitudes are substantially equivalent.
Claim 11
Dependent Claim
34 words
The cardiac stimulation apparatus according to claim 9 wherein said first pulse is between 1 microseconds and 50 microseconds in duration and said second pulse is between 1 microseconds and 50 microseconds in duration.
Claim 12
Dependent Claim
25 words
The cardiac stimulation apparatus according to claim 10 wherein the duration of said second pulse is substantially equivalent to the duration of said first pulse.
Claim 13
Dependent Claim
34 words
The cardiac stimulation apparatus according to claim 1 wherein said first pulse is between 1 microseconds and 50 microseconds in duration and said second pulse is between 1 microseconds and 50 microseconds in duration.
Claim 14
Dependent Claim
25 words
The cardiac stimulation apparatus according to claim 12 wherein the duration of said second pulse is substantially equivalent to the duration of said first pulse.
Claim 15
Dependent Claim
35 words
The cardiac stimulation apparatus according to claim 13 wherein said first pulse has a first current amplitude and said second pulse has a second current amplitude and said first and second amplitudes are substantially equivalent.
Claim 16
Dependent Claim
22 words
The cardiac stimulation apparatus according to claim 14 wherein said second amplitude differs from said first amplitude by less than about 0.1%.
Claim 17
Dependent Claim
25 words
The cardiac stimulation apparatus according to claim 15 wherein the duration of said second pulse differs from said first pulse by less than about 10%.
Claim 18
Dependent Claim
35 words
The cardiac stimulation apparatus according to claim 1 wherein said first pulse has a first current amplitude and said second pulse has a second current amplitude and said first and second amplitudes are substantially equivalent.
Claim 19
Dependent Claim
22 words
The cardiac stimulation apparatus according to claim 17 wherein said second amplitude differs from said first amplitude by less than about 10%.
Claim 20
Dependent Claim
22 words
The cardiac stimulation apparatus according to claim 18 wherein said second amplitude differs from said first amplitude by less than about 0.1%.
Claim 21
Independent Claim
132 words
A method of detecting a changing impedance within a patient's body comprising the steps of producing a constant current biphasic pulse pair, said pulse pair having a first pulse having current flowing in a first direction and a second pulse having current flowing in a second direction, transmitting said pulse pair through at least a portion of said patient's body, detecting a first voltage associated with said first pulse across at least a part of said patient's body, producing a first signal proportional to said first voltage, detecting a second voltage associated with said second pulse across at least a part of said patient's body, producing a second signal proportional to said second voltage, producing a combined signal from said first and second signals, and deriving an impedance from said combined signal.
Claim 22
Independent Claim
132 words
A method of detecting a changing impedance within a patient's body comprising the steps of producing a constant current biphasic pulse pair, said pulse pair having a first pulse having current flowing in a first direction and a second pulse having current flowing in a second direction, transmitting said pulse pair through at least a portion of said patient's body, detecting a first voltage associated with said first pulse across at least a part of said patient's body, producing a first signal proportional to said first voltage, detecting a second voltage associated with said second pulse across at least a part of said patient's body, producing a second signal proportional to said second voltage, producing a combined signal from said first and second signals, and deriving an impedance from said combined signal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
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