US5496557A
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US
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Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances
Assignee: Organon NV
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Filing: 1991-01-30
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Granted: 1996-03-05
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Expires: 2011-01-30
Abstract
Abstract PCT No. PCT/NL91/00013 Sec. 371 Date Aug. 24, 1993 Sec. 102(e) Date Aug. 24, 1993 PCT Filed Jan. 30, 1991 PCT Pub. No. WO91/11176 PCT Pub. Date Aug. 8, 1991.An article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances, which wall is made using a biodegradable polymeric material permeable to the active substance, wherein the wall is composed mainly of a combination of at least two different polymeric materials in which one polymeric material is permeable to the active substance and is degradable and the other polymeric material is relatively poorly permeable to the active substance and is degradable and the conveyor path for the delivery of the active substance from the hollow space to the surroundings of the article is a continuous distance leading at least through the polymeric material permeable to the active substance.
Inventors
- 👤 Jan Feijen
- 👤 Hilbert Esselbrugge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0092; A01; A01N; A01N25/00; A01N25/34
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
163 words
An article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances, wherein the wall is comprised of a portion or portions of a first polymeric material that is permeable to the active substance and is degradable and a portion or portions of a second polymeric material that is poorly permeable to the active substance relative to the first polymeric material and is degradable, and wherein there is a transport path for the delivery of the active substance from the hollow space to the surroundings of the article which is a continuous distance leading through the first polymeric material permeable to the active substance, and wherein the first and second polymeric materials are selected from polyesters, polyorthoesters, poly(α-amino acids), polydepsipeptides, polyanhydrides and polyphosphazenes, co- or block co-polymers derived therefrom and stereo complexes of polymers formed from optically active monomers of these biodegradable polymers.
Claim 2
Dependent Claim
163 words
An article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances, wherein the wall is comprised of a portion or portions of a first polymeric material that is permeable to the active substance and is degradable and a portion or portions of a second polymeric material that is poorly permeable to the active substance relative to the first polymeric material and is degradable, and wherein there is a transport path for the delivery of the active substance from the hollow space to the surroundings of the article which is a continuous distance leading through the first polymeric material permeable to the active substance, and wherein the first and second polymeric materials are selected from polyesters, polyorthoesters, poly(α-amino acids), polydepsipeptides, polyanhydrides and polyphosphazenes, co- or block co-polymers derived therefrom and stereo complexes of polymers formed from optically active monomers of these biodegradable polymers.
Claim 3
Dependent Claim
63 words
An article as claimed in claim 1, wherein it is geometrically based on a hollow tube formed from the two polymeric materials in which the first polymeric material permeable to the active substance and the second poorly permeable polymeric material are each individually formed into a wall portion, which wall portions are assembled into a wall in the form of a two-layered laminate.
Claim 4
Dependent Claim
43 words
An article as claimed in claim 2, wherein the first polymeric material permeable to the active substance and the second poorly permeable polymeric material are composed to form the wall of the article which wall comprises a laminate of more than two layers.
Claim 5
Dependent Claim
39 words
An article as claimed in claim 2, wherein the individual wall sections of the first polymeric material permeable to the active substance and the second material poorly permeable to the active substance are assembled to form a one-layered wall.
Claim 6
Dependent Claim
22 words
An article as claimed in claim 1, wherein the active substances are selected from the group consisting of pharmaceuticals, hormones and peptides.
Claim 7
Dependent Claim
23 words
An article as claimed in claim 1, wherein the active substances are selected from the group consisting of cytostatics, pharmaceuticals, hormones and peptides.
Claim 8
Dependent Claim
22 words
An article as claimed in claim 3, wherein the active substances are selected from the group consisting of hormones, pharmaceuticals and peptides.
Claim 9
Dependent Claim
22 words
An article as claimed in claim 4, wherein the active substances are selected from the group consisting of peptides, pharmaceuticals and hormones.
Claim 10
Dependent Claim
23 words
An article as claimed in claim 1, wherein the active substances are selected from the group consisting of insecticides, herbicides, pheromones and repellents.
Claim 11
Dependent Claim
30 words
An article as claimed in claim 2, wherein the outside diameter of the hollow tube is not more than 5 mm and the length is not more than 10 cm.
Claim 12
Dependent Claim
27 words
An article as claimed in claim 10, wherein for human application the outside diameter of the hollow tube is 1.8 mm and the length is 4 cm.
Claim 13
Dependent Claim
30 words
An article as claimed in claim 1, wherein the permeability of the article to the active substance is effectuated by adjustment of the mutual relative permeability of the polymeric materials.
Claim 14
Dependent Claim
23 words
An article as claimed in claim 1, wherein the active substances are selected from the group consisting of insecticides, herbicides, pheromones and repellents.
Claim 15
Dependent Claim
30 words
An article as claimed in claim 3, wherein the outside diameter of the hollow tube is not more than 5 mm and the length is not more than 10 cm.
Claim 16
Dependent Claim
32 words
An article as claimed in claim 4, characterized in that the outside diameter of the hollow tube is not more than 5 mm and the length is not more than 10 cm.
Claim 17
Dependent Claim
29 words
An article as claimed in claim 10, characterized in that for veterinary application the outside diameter of the hollow tube is 3 mm and the length is 5 cm.
Claim 18
Dependent Claim
44 words
An article as claimed in claim 3, characterized in that the difference in permeability to the active substance is affectable within the employed combination of at least two polymeric materials by adjustment of the mutual relative porosity of the at least two polymeric materials.
Claim 19
Dependent Claim
44 words
An article as claimed in claim 4, characterized in that the difference in permeability to the active substance is affectable within the employed combination of at least two polymeric materials by adjustment of the mutual relative porosity of the at least two polymeric materials.
Claim 20
Dependent Claim
38 words
The article of claim 1, wherein the first and second polymeric materials are selected from the group consisting of the biodegradable copolymers consisting of polylactic acid, polyglycolic acid, poly(hydroxyvalerate), poly(β-hydroxybutyric acid), poly(ε-caprolactone), poly(α-amino acids) and copolymers derived therefrom.
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EP0168862A2
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EP0243263A2
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US4994279A
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GB2216411A
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WO1991005574A1
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-03-05 | 1999-09-04 | 2000-03-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-03-05 | 2003-09-04 | 2004-03-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-03-05 | 2007-09-04 | 2008-03-05 | $7700.00 | Window Closed / Lapsed |