US5491218A
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Artificial positive controls derived from bifunctional conjugates
Assignee: Siemens Healthcare Diagnostics Products GmbH
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Filing: 1994-04-01
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Granted: 1996-02-13
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Expires: 2014-04-01
Abstract
Abstract The invention relates to artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.
Inventors
- 👤 Stefan Brust
- 👤 Heinz-Juergen Friesen
- 👤 Guenther Nau
- 👤 Hans-Erwin Pauly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:40
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/531; G01N33/68; G01N33/6854; G01N33/96; Y; Y10; Y10S; Y10S435/00; Y10S435/967; Y10S435/972; Y10S530/00; Y10S530/861; Y10S530/862; Y10S530/863; Y10S530/866; Y10S530/867
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
38 words
A bi-functional conjugate comprising an antibody of nonhuman origin, wherein said conjugate has: i) a first binding site that specifically binds a specific pathogen; and ii) a second binding site that specifically binds a specific class of immunoglobulin.
Claim 2
Dependent Claim
38 words
A bi-functional conjugate comprising an antibody of nonhuman origin, wherein said conjugate has: i) a first binding site that specifically binds a specific pathogen; and ii) a second binding site that specifically binds a specific class of immunoglobulin.
Claim 3
Dependent Claim
40 words
The conjugate of claim 1 wherein said conjugate comprises two antibodies, wherein one of said two antibodies is an antibody that specifically binds said pathogen and the other antibody of said two antibodies specifically binds said specific class of immunoglobulin.
Claim 4
Dependent Claim
26 words
An artificial positive control comprising the conjugate of claim 1 wherein the second binding site is bound to an antibody of said specific class of immunoglobulin.
Claim 5
Dependent Claim
14 words
An artificial positive control comprising the conjugate of claim 1 in a human serum.
Claim 6
Dependent Claim
16 words
The conjugate of claim 2 wherein at least one of the antibodies is a monoclonal antibody.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-02-12 | 1999-08-14 | 2000-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-02-12 | 2003-08-14 | 2004-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-02-12 | 2007-08-14 | 2008-02-13 | $7700.00 | Window Closed / Lapsed |