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US5489686A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties
Assignee: Warner Lambert Co LLC
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Filing: 1994-04-28
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Granted: 1996-02-06
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Expires: 2014-04-28
Abstract
Abstract This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
Inventors
- 👤 Clifton J. Blankley
- 👤 John C. Hodges
- 👤 Sylvester Klutchko
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:21
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/96; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61P; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P25/24; A61P25/26; A61P25/28; A61P9/00; A61P9/10; C07C; C07C205/00; C07C205/27; C07C205/35; C07C205/36; C07C205/38; C07C229/00; C07C229/02; C07C229/34; C07C229/36; C07C233/00; C07C233/01; C07C233/45; C07C233/46; C07C233/47; C07C43/00; C07C43/02; C07C43/20; C07C43/225; C07C43/23; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C47/00; C07C47/52; C07C47/575; C07D217/00; C07D217/22; C07D217/26; C07D233/54; C07D233/66; C07D233/72; C07D233/76; C07D233/78
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
35 words
A compound selected from: 3-Methoxy-2-(phenylmethoxy)phenylalanine 4-Methoxy-3-(phenylmethoxy)phenylalanine 3-Methoxy-2-(2-phenylethoxy)phenylalanine 3-Methoxy-2-(4-nitrophenoxy)phenylalanine 1,2,3,4-Tetrahydro-6-methoxy-5-(phenylmethoxy-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-7-methoxy-6-(phenylmethoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(2-phenylethoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(4-nitrophenoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid, ethyl ester, 1,2,3,4-Tetrahydro-6-methoxy-5-(4-nitrophenoxy)-3-isoquinolinecarboxylic acid, methyl ester, N-Acetyl-3-methoxy-2-(phenylmethoxy)phenylalanine, 1,2,3,4-Tetrahydro-5-hydroxy-6-methoxy-2-[methyl (phenylamino ) carbonyl]-3-isoquinolinecarboxylic acid, and 2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-3-isoquinolinecarboxylic acid, ethyl ester.
Claim 2
Dependent Claim
35 words
A compound selected from: 3-Methoxy-2-(phenylmethoxy)phenylalanine 4-Methoxy-3-(phenylmethoxy)phenylalanine 3-Methoxy-2-(2-phenylethoxy)phenylalanine 3-Methoxy-2-(4-nitrophenoxy)phenylalanine 1,2,3,4-Tetrahydro-6-methoxy-5-(phenylmethoxy-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-7-methoxy-6-(phenylmethoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(2-phenylethoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(4-nitrophenoxy)-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid, ethyl ester, 1,2,3,4-Tetrahydro-6-methoxy-5-(4-nitrophenoxy)-3-isoquinolinecarboxylic acid, methyl ester, N-Acetyl-3-methoxy-2-(phenylmethoxy)phenylalanine, 1,2,3,4-Tetrahydro-5-hydroxy-6-methoxy-2-[methyl (phenylamino ) carbonyl]-3-isoquinolinecarboxylic acid, and 2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-3-isoquinolinecarboxylic acid, ethyl ester.
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