US5489677A
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Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
Assignee: Ionis Pharmaceuticals Inc
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Filing: 1993-03-31
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Granted: 1996-02-06
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Expires: 2013-03-31
Abstract
Abstract Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected nucleoside sequence wherein the nucleosides are covalently bound through linking groups that contain adjacent nitrogen atoms.
Inventors
- 👤 Yogesh S. Sanghvi
- 👤 Phillip D. Cook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:24
CPC Classifications
C; C07; C07H; C07H21/00; A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; C07D; C07D405/00; C07D405/02; C07D405/04; C07D405/14; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
166 words
A compound having structure: ##STR8## wherein: L 1 -L 2 -L 3 -L 4 is CH 2 --O--NR--CH 2 , CH 2 --NR--O--CH 2 , O--NR--CH 2 --CH 2 , CH 2 --CH 2 --NR--O, CH 2 --CH 2 --O--NR, or NR--O--CH 2 --CH 2 ; R is H, alkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, or alkynyl having 2 to about 10 carbon atoms; B x is a nucleosidic base; Q is O, S, CH 2 , CHF or CF 2 ; n is 1-50; X is H, OH, alkyl, F, Cl, Br, CN, CF 3 , OCF 3 , OCN, O-alkyl, S-alkyl, N-alkyl, O-alkenyl, S-alkenyl, N-alkenyl, SOCH 3 , SO 2 CH 3 , ONO 2 , NO 2 , N 3 , NH 2 , aminoalkylamino, polyalkylamino or substituted silyl, wherein each said alkyl has from 1 to about 10 carbon atoms and each said alkenyl has from 2 to about 10 carbon atoms.
Claim 2
Dependent Claim
166 words
A compound having structure: ##STR8## wherein: L 1 -L 2 -L 3 -L 4 is CH 2 --O--NR--CH 2 , CH 2 --NR--O--CH 2 , O--NR--CH 2 --CH 2 , CH 2 --CH 2 --NR--O, CH 2 --CH 2 --O--NR, or NR--O--CH 2 --CH 2 ; R is H, alkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, or alkynyl having 2 to about 10 carbon atoms; B x is a nucleosidic base; Q is O, S, CH 2 , CHF or CF 2 ; n is 1-50; X is H, OH, alkyl, F, Cl, Br, CN, CF 3 , OCF 3 , OCN, O-alkyl, S-alkyl, N-alkyl, O-alkenyl, S-alkenyl, N-alkenyl, SOCH 3 , SO 2 CH 3 , ONO 2 , NO 2 , N 3 , NH 2 , aminoalkylamino, polyalkylamino or substituted silyl, wherein each said alkyl has from 1 to about 10 carbon atoms and each said alkenyl has from 2 to about 10 carbon atoms.
Claim 3
Dependent Claim
20 words
The compound of claim 1 wherein L 1 -L 2 -L 3 -L 4 is CH 2 --O--NR--CH 2 .
Claim 4
Dependent Claim
20 words
The compound of claim 1 wherein L 1 -L 2 -L 3 -L 4 is CH 2 --NR--O--CH 2 .
Claim 5
Dependent Claim
20 words
The compound of claim 1 wherein L 1 -L 2 -L 3 -L 4 is 0--NR--CH 2 --CH 2 .
Claim 6
Dependent Claim
20 words
The compound of claim 1 wherein L 1 -L 2 -L 3 -L 4 is NR--O--CH 2 --CH 2 .
Claim 7
Dependent Claim
14 words
The compound of claim 1 wherein R is C 1 to C 10 alkyl.
Claim 8
Dependent Claim
9 words
The compound of claim 1 wherein R is methyl.
Claim 9
Dependent Claim
9 words
The compound of claim 1 wherein R is H.
Claim 10
Dependent Claim
9 words
The compound of claim 1 wherein Q is O.
Claim 11
Dependent Claim
11 words
The compound of claim 1 wherein X is H or OH.
Claim 12
Dependent Claim
12 words
The compound of claim 1 wherein R is alkyl, alkenyl or alkynyl.
Claim 13
Dependent Claim
9 words
The compound of claim 1 wherein R is alkyl.
Claim 14
Dependent Claim
9 words
The compound of claim 1 wherein X is F.
Claim 15
Dependent Claim
9 words
The compound of claim 1 wherein X is O-alkyl.
Claim 16
Dependent Claim
15 words
The compound of claim 1 wherein X is O-alkyl having 1 to 4 carbon atoms.
Claim 17
Dependent Claim
9 words
The compound of claim 1 wherein X is O-methyl.
References Cited (Backward Citations)
WO1992005186A1
Cited
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