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US5486204A
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Method of treating a non-penetrating head wound with hypothermia
Assignee: TEXAS HEALTH & SCIENCE CENTER, University of
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Filing: 1994-09-20
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Granted: 1996-01-23
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Expires: 2014-09-20
Abstract
Abstract A method of treating severe brain trauma with hypothermia includes the introduction of specified medication to reduce the risk of cardiac arrhythmia and other malfunctions that may result from the brain trauma or the hypothermia. The method further includes a protocol for the treatment which defines time, temperature, rate of change of temperature, and the timing of the introduction of medications. Finally, rigidly controlled rewarming reduces the incidence of rewarming shock in recovering patients.
Inventors
- 👤 Guy L. Clifton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:51
CPC Classifications
A; A61; A61F; A61F7/00; A61F7/10; A61K; A61K31/00; A61K31/56; A61K31/58
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
118 words
A method of treating brain injury in a human patient comprising the steps of (1) beginning to cool the patient within 6 hours of the brain injury; (2) beginning the introduction of a muscle relaxant and a sedative during the cooling step (1); (3) continuing to cool the patient to 33° C. intravascular temperature; (4) maintaining the patient at 32°-33° C. for 48 hours, continuing the introduction of muscle relaxant and sedative during the maintaining step (4); (5) warming the patient at a rate of 1° C. per 4 hours; (6) discontinuing the introduction of muscle relaxant and sedative when intravascular temperature reaches 35° C.; and (7) discontinuing the warming step when the patient reaches normal body temperature.
Claim 2
Independent Claim
118 words
A method of treating brain injury in a human patient comprising the steps of (1) beginning to cool the patient within 6 hours of the brain injury; (2) beginning the introduction of a muscle relaxant and a sedative during the cooling step (1); (3) continuing to cool the patient to 33° C. intravascular temperature; (4) maintaining the patient at 32°-33° C. for 48 hours, continuing the introduction of muscle relaxant and sedative during the maintaining step (4); (5) warming the patient at a rate of 1° C. per 4 hours; (6) discontinuing the introduction of muscle relaxant and sedative when intravascular temperature reaches 35° C.; and (7) discontinuing the warming step when the patient reaches normal body temperature.
Claim 3
Dependent Claim
28 words
The method of claim 1 wherein the step of cooling includes the steps of applying a cooling blanket to the patient and setting the blanket to 5° C.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein the muscle relaxant comprises vecuronium and the sedative comprises an opiate.
Claim 5
Dependent Claim
16 words
The method of claim 1 further comprising the step of monitoring intracranial pressure of the patient.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein the patient temperature is monitored by bladder temperature.
Claim 7
Dependent Claim
16 words
The method of claim 1 further comprising the step of introducing replacement potassium into the patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-22 | 1999-07-24 | 2000-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-22 | 2003-07-24 | 2004-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-22 | 2007-07-24 | 2008-01-23 | $7700.00 | Window Closed / Lapsed |