US5485229A
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Method and apparatus for determining electrical activity in the retinal nerve fiber layer using intrinsic birefringent properties of retinal ganglion cell axons
Assignee: Allergan Inc
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Filing: 1994-05-24
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Granted: 1996-01-16
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Expires: 2014-05-24
Abstract
Abstract Apparatus and method for measuring retinal function in discrete regions of a retina includes selecting a discrete region of a retina having ganglion cell axons extending therefrom and to an optic nerve head and directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate the optic nerve head. Thereafter the discrete region is stimulated with light. Apparatus is provided for detecting light reflected from the probe region, before, during and after stimulation for producing an electrical signal corresponding to the amount of shifted linearly polarized light as a function of time.
Inventors
- 👤 William A. Hare
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 12:56
CPC Classifications
A; A61; A61B; A61B3/00; A61B3/10; A61B3/12; A61B3/1225
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
119 words
A method for measuring retinal function in discrete regions of a retina, said method comprising the steps of: (a) selecting a discrete region of a retina having ganglion cell axons extending therefrom and to an optic nerve head; (b) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate the optic nerve head and having the ganglion cell axons from the discrete region extending therethrough; (c) stimulating the discrete region with light; (d) detecting light reflected from the probe region, before, during and after stimulation, unshifted linearly polarized light; and (e) analyzing a change in the detected reflected light after stimulation and producing an electrical signal corresponding thereto as a function of time.
Claim 2
Independent Claim
119 words
A method for measuring retinal function in discrete regions of a retina, said method comprising the steps of: (a) selecting a discrete region of a retina having ganglion cell axons extending therefrom and to an optic nerve head; (b) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate the optic nerve head and having the ganglion cell axons from the discrete region extending therethrough; (c) stimulating the discrete region with light; (d) detecting light reflected from the probe region, before, during and after stimulation, unshifted linearly polarized light; and (e) analyzing a change in the detected reflected light after stimulation and producing an electrical signal corresponding thereto as a function of time.
Claim 3
Dependent Claim
49 words
The method according to claim 1 wherein the step of selecting a discrete region further comprises selecting a plurality of adjacent selected regions and thereafter performing steps (b) through (e) on each of the plurality of adjacent selected regions and combining electrical signals in order to map the retina.
Claim 4
Dependent Claim
27 words
The method according to claim 1 further comprising the step of analyzing the electrical signal to determine activities of nerve fiber groups having different mean conduction velocities.
Claim 5
Independent Claim
114 words
A method for determining electrical activity in a retinal nerve fiber layer, said method comprising the steps of: (a) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate an optic nerve head; (b) selecting a region of retina distal from said optic nerve head having ganglion cell with axons extending through the probe region; (c) stimulating the ganglion cell axons in the distal region with light; (d) detecting light reflected from the probe region before, during and after stimulation, unshifted linearly polarized light; and (e) analyzing a change in the detected reflected light after stimulation and producing an electrical signal corresponding thereto as a function of time.
Claim 6
Independent Claim
114 words
A method for determining electrical activity in a retinal nerve fiber layer, said method comprising the steps of: (a) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate an optic nerve head; (b) selecting a region of retina distal from said optic nerve head having ganglion cell with axons extending through the probe region; (c) stimulating the ganglion cell axons in the distal region with light; (d) detecting light reflected from the probe region before, during and after stimulation, unshifted linearly polarized light; and (e) analyzing a change in the detected reflected light after stimulation and producing an electrical signal corresponding thereto as a function of time.
Claim 7
Dependent Claim
50 words
The method according to claim 4 wherein the step of selecting a region of retina further comprises selecting a plurality of selected regions and thereafter performing steps (a) through (e) on each of the plurality of adjacent selected regions and combining electrical signals in order to map an entire retina.
Claim 8
Dependent Claim
27 words
The method according to claim 4 further comprising the step of analyzing the electrical signal to determine activities of nerve fiber groups having different mean conduction velocities.
Claim 9
Independent Claim
130 words
A method of mapping retinal function comprising the steps of: (a) selecting discrete regions of a retina, each discrete region having ganglion cell axons extending therefrom, said ganglion cell axons extending through a corresponding probe region to an optic nerve head; (b) sequentially illuminating each of the probe regions with a linearly polarized beam of light, said probe region being proximate the optic nerve head; (c) stimulating each of the probe regions during laser illumination with a separate light source; (d) detecting light reflected from each of the probe regions; (e) analyzing a change in the detected reflected light after stimulation and producing electrical signals corresponding to an amount of birefringence change of the axons in the probe region; and (f) compiling a retinal map from the analyzed electrical signals.
Claim 10
Independent Claim
130 words
A method of mapping retinal function comprising the steps of: (a) selecting discrete regions of a retina, each discrete region having ganglion cell axons extending therefrom, said ganglion cell axons extending through a corresponding probe region to an optic nerve head; (b) sequentially illuminating each of the probe regions with a linearly polarized beam of light, said probe region being proximate the optic nerve head; (c) stimulating each of the probe regions during laser illumination with a separate light source; (d) detecting light reflected from each of the probe regions; (e) analyzing a change in the detected reflected light after stimulation and producing electrical signals corresponding to an amount of birefringence change of the axons in the probe region; and (f) compiling a retinal map from the analyzed electrical signals.
Claim 11
Dependent Claim
27 words
The method according to claim 7 further comprising the step of analyzing the electrical signals to determine activity of nerve fiber groups having different mean conduction velocities.
Claim 12
Dependent Claim
106 words
Apparatus for determining electrical activity in a retinal nerve fiber layer, said apparatus comprising: optical means for directing a linearly polarized beam of laser light on a probe region of retinal nerve fibers proximate an optic nerve head; light emitting means for stimulating a region of retinal ganglion cells distal from said optic nerve head, the region having ganglion cell axons extending through the probe region; photoelectric means for detecting a beam of laser light reflected from said probe region and emitting an electrical signal corresponding thereto; and polarizer means for filtering the beam of reflected laser light and passing filtered light to said photoelectric means.
Claim 13
Dependent Claim
106 words
Apparatus for determining electrical activity in a retinal nerve fiber layer, said apparatus comprising: optical means for directing a linearly polarized beam of laser light on a probe region of retinal nerve fibers proximate an optic nerve head; light emitting means for stimulating a region of retinal ganglion cells distal from said optic nerve head, the region having ganglion cell axons extending through the probe region; photoelectric means for detecting a beam of laser light reflected from said probe region and emitting an electrical signal corresponding thereto; and polarizer means for filtering the beam of reflected laser light and passing filtered light to said photoelectric means.
Claim 14
Dependent Claim
19 words
The apparatus according to claim 9 further comprising means for analyzing the electric signals for determination of retinal function.
Claim 15
Independent Claim
120 words
A method for determining a change in retinal function, said method comprising the steps of: (a) selecting a discrete region of a retina having ganglion cell axons extending therethrough and to an optic nerve head; (b) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate the optic nerve head and having the ganglion cell axons from the discrete region extending therethrough; (c) stimulating the discrete region with light; (d) detecting light reflected from the probe region, before, during and after stimulation, unshifted linearly polarized light; and (e) receiving shifted linearly polarized light after stimulation and producing an electrical signal corresponding to the amount of shifted linearly polarized light as a function of time.
Claim 16
Independent Claim
120 words
A method for determining a change in retinal function, said method comprising the steps of: (a) selecting a discrete region of a retina having ganglion cell axons extending therethrough and to an optic nerve head; (b) directing a linearly polarized beam of light on a probe region of retinal nerve fibers proximate the optic nerve head and having the ganglion cell axons from the discrete region extending therethrough; (c) stimulating the discrete region with light; (d) detecting light reflected from the probe region, before, during and after stimulation, unshifted linearly polarized light; and (e) receiving shifted linearly polarized light after stimulation and producing an electrical signal corresponding to the amount of shifted linearly polarized light as a function of time.
References Cited (Backward Citations)
No citation records indexed.
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