US5476954A — Process for preparing taxane derivatives, new der…

Claim 1

Independent Claim 271 words

Process for preparing taxane derivatives of general formula: ##STR17## in which R represents a t-butoxy or phenyl radical, R 1 represents a hydrogen atom or an acetyl radical and Ar represents an aryl radical, characterized in that: a) an oxazolidine derivative of general formula: ##STR18## in which Ar is defined as above, Boc represents a t-butoxycarbonyl radical and R 6 and R 7 , which may be identical or different, represent an alkyl radical containing 1 to 4 carbon atoms, optionally substituted with one or more aryl radicals, or an aryl, or alternatively R 6 and R 7 , together with the carbon atom to which they are linked, form a 4- to 7-membered ring, is condensed with a taxane derivative of general formula: ##STR19## in which R' 1 represents an acetyl radical or a group protecting the hydroxyl function and R 2 represents a group protecting the hydroxyl function, to obtain a product of general formula: ##STR20## in which Ar, R' 1 , R 2 , R 6 and R 7 are defined as above, b) the product is treated in an acid medium, under conditions which have no effect on R' 1 and R 2 , to obtain the product of general formula: ##STR21## in which R' 1 and R 2 are defined as above, c) the product is treated with a suitable reagent enabling a t-butoxycarbonyl or benzoyl radical to be introduced on the amino function to obtain a product of general formula: ##STR22## d) the protective groups R' 1 and R 2 are replaced by hydrogen atoms, and then e) the product obtained is isolated and, purified.

Claim 2

Dependent Claim 271 words

Process for preparing taxane derivatives of general formula: ##STR17## in which R represents a t-butoxy or phenyl radical, R 1 represents a hydrogen atom or an acetyl radical and Ar represents an aryl radical, characterized in that: a) an oxazolidine derivative of general formula: ##STR18## in which Ar is defined as above, Boc represents a t-butoxycarbonyl radical and R 6 and R 7 , which may be identical or different, represent an alkyl radical containing 1 to 4 carbon atoms, optionally substituted with one or more aryl radicals, or an aryl, or alternatively R 6 and R 7 , together with the carbon atom to which they are linked, form a 4- to 7-membered ring, is condensed with a taxane derivative of general formula: ##STR19## in which R' 1 represents an acetyl radical or a group protecting the hydroxyl function and R 2 represents a group protecting the hydroxyl function, to obtain a product of general formula: ##STR20## in which Ar, R' 1 , R 2 , R 6 and R 7 are defined as above, b) the product is treated in an acid medium, under conditions which have no effect on R' 1 and R 2 , to obtain the product of general formula: ##STR21## in which R' 1 and R 2 are defined as above, c) the product is treated with a suitable reagent enabling a t-butoxycarbonyl or benzoyl radical to be introduced on the amino function to obtain a product of general formula: ##STR22## d) the protective groups R' 1 and R 2 are replaced by hydrogen atoms, and then e) the product obtained is isolated and, purified.

Claim 3

Dependent Claim 111 words

Process according to claim 1 for the preparation of a product of general formula (I) in which R and R 1 are defined as in claim 1 and Ar represents an optionally substituted phenyl radical or an α- or β-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms and alkyl, aryl, arylalkyl, alkoxy, alkylthio, aryloxy, arylthio, mercapto, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, on the understanding that the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms and that the aryl radicals are phenyl or α- or β-naphthyl radicals.

Claim 4

Dependent Claim 34 words

Process according to one of claims 1 and 2, characterized in that the protective radicals represented by R' 1 and R 2 are 2,2,2-trichloroethoxycarbonyl radicals or radicals which can be converted to 2,2,2-trichloroethoxycarbonyl radicals.

Claim 5

Dependent Claim 42 words

Process according to one of claims 1 to 3, characterized in that the condensation of the product of general formula (II) with the taxane derivative of general formula (III) is performed in the presence of a condensing agent and an activating agent.

Claim 6

Dependent Claim 37 words

Process according to one of claims 1 to 4, characterized in that the selective treatment of the product of general formula (IV) is performed by means of an inorganic or organic acid, where appropriate in an alcohol.

Claim 7

Dependent Claim 37 words

Process according to one of claims 1 to 5, characterized in that the introduction of a t-butoxycarbonyl or benzoyl radical into the product of general formula (V) is performed by means of di-t-butyl dicarbonate or benzoyl chloride.

Claim 8

Dependent Claim 55 words

Process according to one of claims 1 to 6, characterized in that the replacement of the protective groups represented by R' 1 and R 2 by hydrogen atoms is performed with zinc in an acetic acid medium or by means of an inorganic or organic acid in an aliphatic alcohol in the presence of zinc.

Claim 9

Dependent Claim 98 words

The new taxane derivatives of general formula: ##STR23## in which R represents a t-butoxy or phenyl radical and Ar represents a substituted phenyl or α- or β-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms and alkyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, mercapto, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, on the understanding that the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms and that the aryl radicals are phenyl or α- or β-naphthyl radicals.

Claim 10

Dependent Claim 98 words

The new taxane derivatives of general formula: ##STR23## in which R represents a t-butoxy or phenyl radical and Ar represents a substituted phenyl or α- or β-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms and alkyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, mercapto, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, on the understanding that the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms and that the aryl radicals are phenyl or α- or β-naphthyl radicals.

Claim 11

Dependent Claim 12 words

The process according to claim 1, wherein the aryl radical is phenyl.

Claim 12

Dependent Claim 21 words

The process according to claim 2, wherein the halogen atoms are selected from the group comprising fluorine, chlorine, bromine and iodine.

Claim 13

Dependent Claim 21 words

The process according to claim 8, wherein the halogen atoms are selected from the group comprising fluorine, chlorine, bromine and iodine.

Claim 14

Dependent Claim 41 words

Pharmaceutical composition characterized in that it contains a sufficient amount of at least one derivative according to claim 8, in the pure state or in combination with one or more pharmaceutically acceptable products which can be either inert or physiologically active.

Claim 15

Dependent Claim 83 words

The oxazolidine derivatives of general formula: ##STR24## in which Ar is defined according to one of claims 1 and 2, Boc represents a t-butoxycarbonyl radical and R 6 and R 7 , which may be identical or different, represent an alkyl radical containing 1 to 4 carbon atoms, optionally substituted with one or more aryl radicals, or an aryl, or alternatively R 6 and R 7 , together with the carbon atom to which they are linked, form a 4- to 7-membered ring.

Claim 16

Dependent Claim 95 words

Process for preparing an oxazolidine derivative according to claim 13, characterized in that a methoxyalkene optionally substituted with one or more aryl radicals, a dimethoxyalkane optionally substituted with one or more aryl radicals or a gemdimethoxycycloalkane containing 4 to 7 carbon atoms is reacted with a phenylisoserine derivative of general formula: ##STR25## in which Ar is defined according to one of claims 1 and 2, Boc represents a t-butoxycarbonyl radical and R represents an alkyl radical containing 1 to 4 carbon atoms optionally substituted with a phenyl radical, and the product obtained is then saponified.

Claim 17

Dependent Claim 12 words

The process according to claim 13, wherein the aryl radical is phenyl.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-12-18	1999-06-19	1999-12-19	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-12-18	2003-06-19	2003-12-19	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-12-18	2007-06-19	2007-12-19	$7700.00	Window Closed / Lapsed

Process for preparing taxane derivatives, new derivatives obtained and pharmaceutical compositions containing them

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