US5476925A
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Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
Assignee: Northwestern University
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Filing: 1995-01-23
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Granted: 1995-12-19
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Expires: 2015-01-23
Abstract
Abstract Novel oligonucleotides, method for improving the hybridization properties of oligonucleotides and novel processes for preparing 3'-phosphorylated oligonucleotides.
Inventors
- 👤 Robert L. Letsinger
- 👤 Sergei M. Gryaznov
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:06
CPC Classifications
C; C07; C07H; C07H21/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
40 words
An oligodeoxyribonucleotide consisting of nucleosides wherein the base is selected from adenine, thymine, cytosine, guanine and uracil and from 1 to 4 internucleosides having the structure ##STR12## and ##STR13## and wherein the remainder of the internucleoside links are phosphodiester links.
Claim 2
Dependent Claim
40 words
An oligodeoxyribonucleotide consisting of nucleosides wherein the base is selected from adenine, thymine, cytosine, guanine and uracil and from 1 to 4 internucleosides having the structure ##STR12## and ##STR13## and wherein the remainder of the internucleoside links are phosphodiester links.
Claim 3
Dependent Claim
10 words
An oligodeoxyribonucleotide of claim 1 including 10 to 30 nucleosides.
Claim 4
Dependent Claim
15 words
An oligonucleotide of claim 1 having 1 or 2 internucleoside links of the structure: ##STR14##
Claim 5
Dependent Claim
11 words
An oligonucleotide of claim 3 having from 10 to 12 nucleosides.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1998-12-18 | 1999-06-19 | 1999-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-18 | 2003-06-19 | 2003-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-18 | 2007-06-19 | 2007-12-19 | $7700.00 | Window Closed / Lapsed |