US5474070A
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Method and apparatus for elastographic measurement and imaging
Assignee: The University of Texas System
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Filing: 1994-03-11
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Granted: 1995-12-12
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Expires: 2014-03-11
Abstract
Abstract An improved ultrasonic pulse-echo method and apparatus that has particular application in making precision measurements of compressibility in any backscattering material, in particular organic tissue, is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is detected from regions within the target along the sonic travel path or beam of the transducer. Resulting time shifts in echo segments corresponding to features in the target, corrected for regions of varying sonic speed along the sonic path, provide relative and quantitative information concerning the strain caused by the compressions. The stress imparted by the transducer and containing device is also determined, corrected for depth along the sonic path. The appropriate values for stress are divided into the respective values for strain along each path to yield an elastogram, or array of compressibility values, of the target.
Inventors
- 👤 Jonathan Ophir
- 👤 Ignacio Cespedes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:04
CPC Classifications
G; G01; G01S; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/8934; G01S15/8945; A; A61; A61B; A61B5/00; A61B5/0048; G01N; G01N29/00; G01N29/04; G01N29/07; G01N29/22; G01N29/223; G01N29/30; G01N29/36; G01N29/38; G01N29/44; G01N29/50; G01S7/00; G01S7/52; G01S7/52017; G01S7/52023; G01S7/52036; G01S7/52042; G01N2203/00; G01N2203/0058; G01N2203/0089; G01N2291/00; G01N2291/02; G01N2291/028; G01N2291/02827; G01N2291/10; G01N2291/101
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
271 words
A method for taking elastographic measurements of a heterogeneous target body comprising the steps of: (a) sonically coupling an ultrasonic source to the surface of a target body; (b) emitting a first pulse of ultrasonic energy from the source along a radiation axis in the target body; (c) recording the arrival time of the first echo sequence having at least one echo segment arriving in response to said first pulse of ultrasonic energy; (d) displacing the surface of the target body a known displacement, ΔX, along a force axis so as to compress the target body; (e) emitting a next pulse of ultrasonic energy from the source along said radiation axis in the target body following said movement; (f) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (g) measuring the differential displacement from at least one congruent echo segment of the two most recent pulses of ultrasonic energy; (h) calculating the strain from the differential displacement data obtained in step (g); (i) storing strain data that meets a predetermined quality standard in a retrievable medium; (j) normalizing the calculated strain data stored in step (i) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (k) repeating steps (d)-(j) until enough strain data has been stored to produce an image of the tissue body region under interrogation.
Claim 2
Independent Claim
271 words
A method for taking elastographic measurements of a heterogeneous target body comprising the steps of: (a) sonically coupling an ultrasonic source to the surface of a target body; (b) emitting a first pulse of ultrasonic energy from the source along a radiation axis in the target body; (c) recording the arrival time of the first echo sequence having at least one echo segment arriving in response to said first pulse of ultrasonic energy; (d) displacing the surface of the target body a known displacement, ΔX, along a force axis so as to compress the target body; (e) emitting a next pulse of ultrasonic energy from the source along said radiation axis in the target body following said movement; (f) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (g) measuring the differential displacement from at least one congruent echo segment of the two most recent pulses of ultrasonic energy; (h) calculating the strain from the differential displacement data obtained in step (g); (i) storing strain data that meets a predetermined quality standard in a retrievable medium; (j) normalizing the calculated strain data stored in step (i) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (k) repeating steps (d)-(j) until enough strain data has been stored to produce an image of the tissue body region under interrogation.
Claim 3
Dependent Claim
13 words
The method of claim 1, wherein said target body is a tissue body.
Claim 4
Dependent Claim
15 words
The method of claim 1, wherein the differential displacement is measured by a cross-correlation technique.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein the differential displacement is measured by a phase of the analytic signal.
Claim 6
Dependent Claim
17 words
The method of claim 1, wherein the differential displacement is measured by a phase of the cross-spectrum.
Claim 7
Dependent Claim
28 words
The method of claim 1, wherein said sonic coupling is achieved by placing an adjustable volume coupling device between the transducer and the surface of the target body.
Claim 8
Dependent Claim
16 words
The method of claim 6, wherein said coupling device is volume adjustable by inflation and deflation.
Claim 9
Dependent Claim
22 words
The method of claim 6, wherein the surface of the target body is displaced by changing the volume of the coupling device.
Claim 10
Dependent Claim
202 words
The method of claim 1, further comprising the steps of: (a) displacing the surface of the target body a known displacement, AX, along the force axis so as to decompress the target body; (b) emitting a next pulse of ultrasonic energy from the source along the radiation axis in the target body following said movement; (c) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (d) measuring the differential displacement from at least one congruent echo segment of the two most recent pulses of ultrasonic energy; (e) calculating the strain from the differential displacement data obtained in step (d); (f) storing strain data that meets a predetermined quality standard in a retrievable medium; (g) normalizing the calculated strain data stored in step (f) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (h) repeating steps (a)-(g) until the number of decompression intervals equal the number of compression intervals.
Claim 11
Dependent Claim
25 words
The method of claim 9, wherein each displacement of the surface of the target body results in an elastic wave traveling within the target body.
Claim 12
Dependent Claim
44 words
The method of claim 10, wherein the elapsed time between the emission of the first and last pulse of ultrasonic energy from the source is large enough to allow the elastic wave to travel to the desired depth of interrogation within the target body.
Claim 13
Dependent Claim
108 words
The method of claim 1 further comprising the step of calculating the displacement shift of the interrogated target body region from its initial position at each displacement interval, ΔTB n , using the following formula: ##EQU6## where: ΔTB n is the interrogated target body region displacement at displacement interval n; X o is the initial displacement of the target body surface along the force axis; X n is the displacement of the target body surface along the force axis at displacement interval n; NS n is the normalized strain at displacement interval n; and dx is the differential displacement of the target body surface along the force axis.
Claim 14
Dependent Claim
22 words
The method of claim 12, wherein the equation for calculating the displacement shift of the interrogated target body region is solved numerically.
Claim 15
Dependent Claim
28 words
The method of claim 1, wherein said ultrasound source comprises an array of transducers capable of emitting ultrasound energy in a preselected sequence at a preselected emission interval.
Claim 16
Independent Claim
447 words
A method for taking elastographic measurements of a heterogeneous target body comprising the steps of: (a) sonically coupling an ultrasonic source to a target body; (b) emitting a first pulse of ultrasonic energy from the source along a radiation axis in the target body; (c) recording the arrival time of the first echo sequence having at least one echo segment arriving in response to said first pulse of ultrasonic energy; (d) moving the ultrasonic source a known displacement, ΔX, along a force axis so as to compress the target body; (e) emitting a next pulse of ultrasonic energy from the source along the radiation axis in the target body following said movement; (f) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (g) measuring the differential displacement from at least one congruent echo segment of the first pulse and most recent pulse of ultrasonic energy; (h) calculating the strain from the differential displacement data obtained in step (g); (i) storing strain data that meets a predetermined quality standard in a retrievable medium; (j) normalizing the calculated strain data stored in step (i) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (k) repeating steps (d)-(j) until the ultrasonic source has traveled a desired compression distance; (l) moving the ultrasonic source a known displacement, ΔX, along the force axis so as to decompress the target body; (m) emitting a next pulse of ultrasonic energy from the source along the radiation axis in the target body following said movement; (n) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (o) measuring the strain from at least one congruent echo segment of the first pulse and most recent pulse of ultrasonic energy; (p) calculating the strain from the differential displacement data obtained in step (o); (q) storing strain data that meets a predetermined quality standard in a retrievable medium; (r) normalizing the calculated strain data stored in step (q) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (s) repeating steps (l)-(r) until the ultrasonic source has traveled a desired decompression distance.
Claim 17
Independent Claim
447 words
A method for taking elastographic measurements of a heterogeneous target body comprising the steps of: (a) sonically coupling an ultrasonic source to a target body; (b) emitting a first pulse of ultrasonic energy from the source along a radiation axis in the target body; (c) recording the arrival time of the first echo sequence having at least one echo segment arriving in response to said first pulse of ultrasonic energy; (d) moving the ultrasonic source a known displacement, ΔX, along a force axis so as to compress the target body; (e) emitting a next pulse of ultrasonic energy from the source along the radiation axis in the target body following said movement; (f) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (g) measuring the differential displacement from at least one congruent echo segment of the first pulse and most recent pulse of ultrasonic energy; (h) calculating the strain from the differential displacement data obtained in step (g); (i) storing strain data that meets a predetermined quality standard in a retrievable medium; (j) normalizing the calculated strain data stored in step (i) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (k) repeating steps (d)-(j) until the ultrasonic source has traveled a desired compression distance; (l) moving the ultrasonic source a known displacement, ΔX, along the force axis so as to decompress the target body; (m) emitting a next pulse of ultrasonic energy from the source along the radiation axis in the target body following said movement; (n) recording the arrival time of a next echo sequence arriving in response to said next pulse of ultrasonic energy, said echo sequence having at least one echo segment that is congruent with at least one said echo segment that arrived in response to the preceding pulse; (o) measuring the strain from at least one congruent echo segment of the first pulse and most recent pulse of ultrasonic energy; (p) calculating the strain from the differential displacement data obtained in step (o); (q) storing strain data that meets a predetermined quality standard in a retrievable medium; (r) normalizing the calculated strain data stored in step (q) using the formula: NS n =CS n /n where: NS n =normalized strain at displacement interval n CS n =calculated strain at displacement interval n; and (s) repeating steps (l)-(r) until the ultrasonic source has traveled a desired decompression distance.
Claim 18
Dependent Claim
14 words
The method of claim 15, wherein the displacement is measured by a cross-correlation technique.
Claim 19
Dependent Claim
17 words
The method of claim 15, wherein the strain is measured by a phase of the analytic signal.
Claim 20
Dependent Claim
16 words
The method of claim 15, wherein the strain is measured by a phase of the cross-spectrum.
Claim 21
Dependent Claim
18 words
The method of claim 15, further comprising the step of displaying an image of the stored strain data.
Claim 22
Dependent Claim
27 words
The method of claim 15, wherein the compression distance that the ultrasonic source is moved is equal to the decompression distance that the ultrasonic source was moved.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-12-11 | 1999-06-12 | 1999-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-11 | 2003-06-12 | 2003-12-12 | $3760.00 | Window Closed / Lapsed |
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