Purine analog nucleoside and nucleotide compounds

Claim 1

Nucleoside derivatives of formula I ##STR6## wherein Ba is an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) group, of the following formulae, respectively: ##STR7## wherein R 1 , R 2 , R 3 , which can be the same or different, are hydrogen, halogen, C 1 -C 7 -alkyl, C 2 -C 7 -alkenyl, hydroxy, mercapto, C 1 -C 7 -alkylthio, C 1 -C 7 -alkoxy, C 2 -C 7 -alkenyloxy, aryl-C 1 -C 5 -alkyl, aryl-C 2 -C 5 -alkenyl, aryl-C 1 -C 5 -alkoxy, aryl-C 2 -C 5 -alkenyloxy, aryloxy, nitro, amino-C 1 -C 7 -alkyl, C 1 -C 7 -alkylamino-C 1 -C 7 -alkyl, di-C 1 -C 7 -alkylamino-C 1 -C 7 -alkyl, amino, substituted amino group of the formula --NHR 4 or --N(R 4 ) 2 or an imino group --N═CH--R 4 , wherein R 4 is C 1 -C 7 -alkyl, C 2 -C 7 -alkenyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 7 -alkyl, C 3 -C 7 -cycloalkenyl, C 1 -C 7 -alkoxy-C 1 -C 7 -alkyl, halogen-C 1 -C 7 -alkyl, hydroxy-C 1 -C 7 -alkyl, aryl-C.sub. 1 -C 5 -alkyl, aryl-C 2 -C 5 -alkenyl, hetaryl-C 1 -C 5 -alkyl or hetaryl-C 2 -C 5 -alkenyl radical, wherein the aryl and hetaryl moieties are unsubstituted or are substituted one, two or three times by C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkoxy, halogen or hydroxyl, or R 4 is amino-C 1 -C 7 -alkyl, C 1 -C 7 -alkylamino-C 1 -C 7 -alkyl or di-C 1 -C 7 -alkylamino-C 1 -C 7 -alkyl and, in the case of the --NHR 4 and --N═CH--R 4 groups, R 4 can additionally be amino, C 1 -C 7 -alkylamino, di-C 1 -C 7 -alkylamino or C 1 -C 7 -alkoxy or, in the case of the --N(R 4 )2 group, the two nitrogen substituents R 4 together can form a C 1 -C 7 -alkylidene group which, in turn, can be unsubstituted or substituted by C 1 -C 7 -alkoxy, C 1 -C 7 -alkylamino or di-C 1 -C 7 -alkylamino, wherein said aryl is phenyl or naphthyl and said hetaryl is furanyl, thienyl or pyridyl, R 5 , R 6 , R 7 , and R 8 each are hydrogen, or one or two of R 5 , R 6 , R 7 , and R 8 are hydroxyl, halogen, cyano, azido or a substituted amino group --NHR 4 or --N(R 4 ) 2 , or and R 5 and R 7 can together represent a further bond between C-2' and C-3', and Y is hydrogen or C 1 -C 7 -alkylcarbonyl, monophosphate, diphosphate or triphosphate, with the provisos that a) when R 6 is a hydroxyl group, R 8 is other than a hydrogen atom or a hydroxyl group, b) when Ba is the group (B) , R 6 is other than a halogen, amino or azido group, c) when Ba is the group (D) and R 2 is hydrogen, R 1 is other than chlorine or amino and R 6 is other than hydrogen or chlorine, and d) When Ba is the group (E) and R 1 is amino, R 5 and R 7 cannot together represent a bond, as well as their possible α and β-anomers, , N 7 -, N 8 - or N 9 regioisomers (purine nomenclature), tautomers and salts, and nucleic acids which contain compounds of the formula I as constructional units.