US5444164A
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TGF-β induced gene
Assignee: Bristol Myers Squibb Co
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Filing: 1992-05-04
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Granted: 1995-08-22
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Expires: 2012-05-04
Abstract
Abstract A new TGF- beta induced gene and protein is described. Treatment of TGF- beta growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF- beta , and is shown to inhibit the growth of tumor cells.
Inventors
- 👤 Anthony F. Purchio
- 👤 John E. Skonier
- 👤 Michael G. Neubauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:36
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/71
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
An isolated nueleic acid sequence whose expression is induced by contacting cells which are A549 cells or H2981 cells with a TGFβ protein which is selected from the group consisting of TGFβ-1 and TGFβ-2, said nucleic acid sequence having SEQ ID #1.
Claim 2
Dependent Claim
42 words
An isolated nueleic acid sequence whose expression is induced by contacting cells which are A549 cells or H2981 cells with a TGFβ protein which is selected from the group consisting of TGFβ-1 and TGFβ-2, said nucleic acid sequence having SEQ ID #1.
Claim 3
Dependent Claim
25 words
The nucleic acid sequence of claim 1, wherein said TGFβ protein induces the production of a 3.4 kilobase RNA transcript from said nucleic acid sequence.
Claim 4
Dependent Claim
19 words
The nucleic acid sequence according to claim 1, wherein said nucleic acid sequence encodes the expression of βIG-H3 protein.
Claim 5
Dependent Claim
53 words
An isolated nucleic acid sequence which encodes βIG-H3 protein, said protein having SEQ ID #2, and whereto said protein is encoded by a nucleic acid sequence whose expression is reduced in cells which are A549 and H2981 cells with a TGFβ protein which is selected from the group consisting of TGFβ-1 or TGFβ-2.
Claim 6
Dependent Claim
53 words
An isolated nucleic acid sequence which encodes βIG-H3 protein, said protein having SEQ ID #2, and whereto said protein is encoded by a nucleic acid sequence whose expression is reduced in cells which are A549 and H2981 cells with a TGFβ protein which is selected from the group consisting of TGFβ-1 or TGFβ-2.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-08-21 | 1999-02-20 | 1999-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-08-21 | 2003-02-20 | 2003-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-08-21 | 2007-02-20 | 2007-08-22 | $7700.00 | Window Closed / Lapsed |