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US5440040A Expired / Lapsed US ⏱️ 0.0 years remaining

Pyrimidine intermediates

Assignee: Medivir AB
•
Filing: 1989-06-07
•
Granted: 1995-08-08
•
Expires: 2009-06-07
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Abstract

Abstract The present invention is directed to compounds of formula (I), ##STR1## wherein R 1 is OH, NH 2 ; R 2 is a heteroaromatic or aromatic substituent; R 3 is H, OH, F, OCH 3 ; R 4 is H, F, OH or an ether or ester residue thereof, OCH 3 , CN, C═CH, N 3 ; R 5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (α), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections. The present invention is also directed to compounds of formula (I'), ##STR2## wherein R 1 and R 2 are as defined above, as intermediates.

Inventors

  • 👤 Salo Gronowitz

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 22:25
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/34; C07D239/36; A; A61; A61P; A61P31/00; A61P31/12; C07D401/00; C07D401/02; C07D401/04; C07D403/00; C07D403/02; C07D403/04; C07D405/00; C07D405/02; C07D405/04; C07D409/00; C07D409/02; C07D409/04; C07D417/00; C07D417/02; C07D417/04; C07D495/00; C07D495/02; C07D495/04; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 137 words
A compound of the formula ##STR17## wherein R 1 and R 2 are defined as follows R 1 is OH, NH 2 ; R 2 is ##STR18## wherein X is O, S, N--R 7 , Se; R 6 is H, straight or branched C 1-10 alkyl, F, Cl, Br, I, X--R 7 , --CH═CH--R 7 , --C═C--R 7 , CO 2 R 7 , CH 2 X--R 7 ; R 7 is H, straight or branched C 1-15 alkyl, phenyl; with the provisos that when R 1 is OH, R 2 is not ##STR19## when R 6 is H, straight or branched C 1-10 alkyl, or X--R 7 when X is O and R 7 is H, or straight or branched C 1-15 alkyl; and when R 1 is NH 2 , R 2 is not ##STR20##
Claim 2
Dependent Claim 137 words
A compound of the formula ##STR17## wherein R 1 and R 2 are defined as follows R 1 is OH, NH 2 ; R 2 is ##STR18## wherein X is O, S, N--R 7 , Se; R 6 is H, straight or branched C 1-10 alkyl, F, Cl, Br, I, X--R 7 , --CH═CH--R 7 , --C═C--R 7 , CO 2 R 7 , CH 2 X--R 7 ; R 7 is H, straight or branched C 1-15 alkyl, phenyl; with the provisos that when R 1 is OH, R 2 is not ##STR19## when R 6 is H, straight or branched C 1-10 alkyl, or X--R 7 when X is O and R 7 is H, or straight or branched C 1-15 alkyl; and when R 1 is NH 2 , R 2 is not ##STR20##
Claim 3
Dependent Claim 50 words
A compound of the formula: ##STR21## wherein R 1 and R 2 are defined as follows: R 1 is OH, NH 2 ; R 2 is 2-thienyl, 2-seleniynyl, 2-furyl, 2-thiazolyl, 2-(1-methyl)pyrrolyl or methoxyphenyl, with the proviso that when R 1 is OH, R 2 is not 2-thienyl, 2-seleniynyl or methoxyphenyl.
Claim 4
Dependent Claim 50 words
A compound of the formula: ##STR21## wherein R 1 and R 2 are defined as follows: R 1 is OH, NH 2 ; R 2 is 2-thienyl, 2-seleniynyl, 2-furyl, 2-thiazolyl, 2-(1-methyl)pyrrolyl or methoxyphenyl, with the proviso that when R 1 is OH, R 2 is not 2-thienyl, 2-seleniynyl or methoxyphenyl.

References Cited (Backward Citations)

US4182859A Cited
US4211773A Cited
US4666892A Cited
WO1988004662A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1998-08-07 1999-02-06 1999-08-08 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2002-08-07 2003-02-06 2003-08-08 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2006-08-07 2007-02-06 2007-08-08 $7700.00 Window Closed / Lapsed

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