US5438050A
Expired / Lapsed
US
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Indolocarbazole derivatives, processes for their preparation and compositions containing them
Assignee: Goedecke GmbH
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Filing: 1994-01-21
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Granted: 1995-08-01
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Expires: 2014-01-21
Abstract
Abstract New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.
Inventors
- 👤 Jurgen Kleinschroth
- 👤 Johannes Hartenstein
- 👤 Hubert Barth
- 👤 Christoph Schachtele
- 👤 Claus Rudolph
- 👤 Gunter Weinheimer
- 👤 Hartmut Osswald
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:00
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/12; C07D487/14
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
140 words
A compound of the formula ##STR11## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 taken together are alkylene of from 2-4 carbon atoms unsubstituted or substituted by hydroxyl, alkoxy of 1-4 carbon atoms or amino which is unsubstituted or is mono- or di-substituted by benzyl or by alkyl of from 1-4 carbon atoms; X and Y are each hydrogen or one is hydrogen and the other is hydroxyl or alkoxy of from 1-4 carbon atoms; R 3 , R 4 , R 5 , R 6 , and R 10 are each independently hydrogen, bromine, chlorine, methyl, ethyl, hydroxyl methoxy, 2-aminoethoxy, 3-aminopropoxy, 1-amino-2-propoxy, 2-dimethylaminoethoxy, 3-dimethylamino-1-propoxy, 3-dimethylamino-2-propoxy, or 2-diethylaminoethoxy; R 6 and R 7 are hydrogen with the proviso that at least one and as many as four of R 3 to R 4 are not hydrogen.
Claim 2
Dependent Claim
140 words
A compound of the formula ##STR11## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 taken together are alkylene of from 2-4 carbon atoms unsubstituted or substituted by hydroxyl, alkoxy of 1-4 carbon atoms or amino which is unsubstituted or is mono- or di-substituted by benzyl or by alkyl of from 1-4 carbon atoms; X and Y are each hydrogen or one is hydrogen and the other is hydroxyl or alkoxy of from 1-4 carbon atoms; R 3 , R 4 , R 5 , R 6 , and R 10 are each independently hydrogen, bromine, chlorine, methyl, ethyl, hydroxyl methoxy, 2-aminoethoxy, 3-aminopropoxy, 1-amino-2-propoxy, 2-dimethylaminoethoxy, 3-dimethylamino-1-propoxy, 3-dimethylamino-2-propoxy, or 2-diethylaminoethoxy; R 6 and R 7 are hydrogen with the proviso that at least one and as many as four of R 3 to R 4 are not hydrogen.
Claim 3
Dependent Claim
8 words
A compound described as 12, 13-butano-6,7,12,13-tetrahydro-5-oxo-5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole.
Claim 4
Dependent Claim
8 words
A compound described as 12, 13-butano-6,7,12,13-tetrahydro-5-oxo-5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole.
Claim 5
Dependent Claim
143 words
The compound of the formula ##STR12## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 taken together are alkylene of from 2-4 carbon atoms unsubstituted or substituted by hydroxyl, alkoxy of 1-4 carbon atoms or amino which is unsubstituted or is mono- or di-substituted by benzyl or by alkyl of from 1-4 carbon atoms; X and Y are each hydrogen or one is hydrogen and the other is hydroxyl or alkoxy of from 1-4 carbon atoms; R 3 , R 4 , R 5 , R 6 , R 9 and R 10 are each independently hydrogen, bromine, chlorine, alkyl of from 1-4 carbon atoms or alkoxy of from 1-4 carbon atoms; R 6 and R 7 are hydrogen with the proviso that at least one and as many as four of R 3 to R 10 are not hydrogen.
Claim 6
Dependent Claim
143 words
The compound of the formula ##STR12## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 taken together are alkylene of from 2-4 carbon atoms unsubstituted or substituted by hydroxyl, alkoxy of 1-4 carbon atoms or amino which is unsubstituted or is mono- or di-substituted by benzyl or by alkyl of from 1-4 carbon atoms; X and Y are each hydrogen or one is hydrogen and the other is hydroxyl or alkoxy of from 1-4 carbon atoms; R 3 , R 4 , R 5 , R 6 , R 9 and R 10 are each independently hydrogen, bromine, chlorine, alkyl of from 1-4 carbon atoms or alkoxy of from 1-4 carbon atoms; R 6 and R 7 are hydrogen with the proviso that at least one and as many as four of R 3 to R 10 are not hydrogen.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition for treating blood vessel diseases comprising an effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
27 words
A method for treating diseases of blood vessels which comprises treating a host suffering therefrom with a pharmaceutical composition according to claim 1 in unit dosage form.
Claim 9
Dependent Claim
17 words
A compound according to claim 1 wherein R 5 or R 8 is methoxy, methyl, or chloro.
Claim 10
Dependent Claim
17 words
A compound according to claim 1 wherein R 4 or R 9 is methoxy, methyl, or chloro.
Claim 11
Dependent Claim
20 words
A compound according to claim 1 wherein R 5 and R 8 are both methoxy, hydroxyl, methyl, bromo, or chloro.
Claim 12
Dependent Claim
19 words
A compound according to claim 1 wherein R 4 and R 9 are both methoxy, methyl, bromo, or chloro.
Claim 13
Dependent Claim
24 words
A compound according to claim 1 wherein R 4 and R 5 or R 8 and R 9 are the same and are methoxy.
Claim 14
Dependent Claim
35 words
A compound according to claim 1 wherein R 4 , R 5 , R 8 , and R 9 are methoxy and R 3 , R 6 , R 7 and R 10 are hydrogen.
Claim 15
Dependent Claim
22 words
A pharmaceutical composition comprising an effective amount of a compound as defined in claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
32 words
A method for treating and/or preventing heart and blood vessel diseases which comprises administering to a mammal in need of such treatment a composition according to claim 12 in unit dosage form.
Claim 17
Dependent Claim
26 words
A compound according to claim 1 wherein R 1 and R 2 when taken together form a butylene or a propylene radical unsubstituted or hydroxy substituted.
References Cited (Backward Citations)
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| 7.5 Years (Year 8) | 2002-07-31 | 2003-01-30 | 2003-08-01 | $3760.00 | Window Closed / Lapsed |
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