US5425580A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dosage form for micro-bubble echo contrast agents
Assignee: Takeda GmbH
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Filing: 1994-08-02
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Granted: 1995-06-20
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Expires: 2014-08-02
Abstract
Abstract A dosage form for micro bubble echo contrast media which comprises a syringe (6) and a mixing chamber (1) which is connected thereto and contains a predetermined amount of gas, plus a second syringe is described. The novel dosage form allows easy, standardised preparation of echo contrast media and gives high contrast (FIG. 3).
Inventors
- 👤 Klaus-Dieter Beller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:07
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/005; B; B01; B01F; B01F25/00; B01F25/30; B01F25/31; B01F25/311; B01F25/3111; B01F25/31112; B01F25/40; B01F25/42; B01F25/43; B01F25/431; B01F25/43197; B01F25/431971; B01F25/45; B01F25/452; B01F25/4521; B01F31/00; B01F31/44; B01F31/441; B01F33/00; B01F33/50; B01F33/501; B01F33/5011; B01F33/50112; B01F35/00; B01F35/71; B01F35/716; B01F35/7161; B01F35/7163; B01F35/717; B01F35/7174; A61J; A61J1/00; A61J1/14; A61J1/20; A61J1/2003; A61J1/202; A61J1/2044; A61J1/2096; B01F25/4317; B01F25/43172; B01F35/30; B01F35/32; B01F35/32005; B01F35/3202
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
50 words
A combination of a) means for generating micro bubbles in an echo contrast medium with b) a mixing chamber and c) a predetermined amount of sterile gas, wherein the means is a syringe which has an outlet sealed to the mixing chamber which contains the predetermined amount of sterile gas.
Claim 2
Dependent Claim
50 words
A combination of a) means for generating micro bubbles in an echo contrast medium with b) a mixing chamber and c) a predetermined amount of sterile gas, wherein the means is a syringe which has an outlet sealed to the mixing chamber which contains the predetermined amount of sterile gas.
Claim 3
Dependent Claim
23 words
A combination of claim 1 wherein the mixing chamber has an inner lumen in which the predetermined amount of sterile gas is contained.
Claim 4
Dependent Claim
22 words
A combination of claim 2 wherein the mixing chamber is tubular and comprises a plurality of mixing elements in the inner lumen.
Claim 5
Dependent Claim
15 words
A combination of claim 3 wherein the mixing elements are in the form of spikes.
Claim 6
Dependent Claim
16 words
A combination of claim 3 wherein the mixing elements are in a mutually offset helical arrangement.
Claim 7
Dependent Claim
15 words
A combination of claim 3 wherein the mixing chamber comprises one or more perforated diaphragms.
Claim 8
Dependent Claim
48 words
A set which is useful for applying micro-bubble echo contrast media and which comprises: a) a combination of claim 1, b) a second syringe, c) echo contrast medium, and d) optionally, another container; the echo contrast medium being contained in the second syringe or in the other container.
Claim 9
Dependent Claim
79 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, an inner lumen and a predetermined amount of sterile gas in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having an outlet means for connecting it to the outlet of the mixing chamber.
Claim 10
Dependent Claim
79 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, an inner lumen and a predetermined amount of sterile gas in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having an outlet means for connecting it to the outlet of the mixing chamber.
Claim 11
Dependent Claim
16 words
Apparatus according to claim 8, wherein the mixing chamber has mixing elements in the inner lumen.
Claim 12
Dependent Claim
15 words
Apparatus according to claim 9, wherein the mixing elements are in the form of spikes.
Claim 13
Dependent Claim
19 words
Apparatus according to claim 10, wherein the mixing elements have sharp edges in the direction of the syringe barrel.
Claim 14
Dependent Claim
16 words
Apparatus according to claim 9, wherein the mixing elements are in a mutually offset helical arrangement.
Claim 15
Dependent Claim
15 words
Apparatus according to claim 9, wherein the mixing chamber comprises one or more perforated diaphragms.
Claim 16
Dependent Claim
17 words
Apparatus according to claim 8, wherein the first syringe and the mixing chamber are fabricated from plastic.
Claim 17
Dependent Claim
23 words
Apparatus of claim 8 wherein the outlet means of the second syringe is directly connected to the outlet means of the mixing chamber.
Claim 18
Dependent Claim
15 words
Apparatus according to claim 15, wherein the second syringe contains a liquid contrast medium component.
Claim 19
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, one or more perforated diaphragms, an inner lumen and a plurality of mixing elements in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means for connecting it to the outlet of the mixing chamber.
Claim 20
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, one or more perforated diaphragms, an inner lumen and a plurality of mixing elements in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means for connecting it to the outlet of the mixing chamber.
Claim 21
Dependent Claim
22 words
Apparatus of claim 17 wherein the outlet means of the second syringe is directly connected to the outlet of the mixing chamber.
Claim 22
Dependent Claim
16 words
Apparatus of claim 18 wherein the first syringe and the mixing chamber are fabricated from plastic.
Claim 23
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having a inlet, an outlet, an inner lumen and a plurality of mixing elements, in the form of spikes, in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means for connecting it to the outlet of the mixing chamber.
Claim 24
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having a inlet, an outlet, an inner lumen and a plurality of mixing elements, in the form of spikes, in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means for connecting it to the outlet of the mixing chamber.
Claim 25
Dependent Claim
18 words
Apparatus of claim 20 wherein the mixing elements have sharp edges in the direction of the syringe barrel.
Claim 26
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, an inner lumen and a plurality of mixing elements, in a mutually offset helical arrangement, in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means directly connected to the outlet of the mixing chamber.
Claim 27
Dependent Claim
82 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; the mixing chamber having an inlet, an outlet, an inner lumen and a plurality of mixing elements, in a mutually offset helical arrangement, in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe having outlet means directly connected to the outlet of the mixing chamber.
Claim 28
Dependent Claim
83 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; a mixing chamber having an inlet, an outlet, an inner lumen and a plurality of mixing elements in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe containing a liquid contrast medium component and having outlet means directly connected to the outlet of the mixing chamber.
Claim 29
Dependent Claim
83 words
Apparatus useful for preparing micro bubble echo contrast media and comprising a first syringe, a mixing chamber and a second syringe; a mixing chamber having an inlet, an outlet, an inner lumen and a plurality of mixing elements in the inner lumen; the first syringe comprising a barrel and having an outlet sealed to the inlet of the mixing chamber; and the second syringe containing a liquid contrast medium component and having outlet means directly connected to the outlet of the mixing chamber.
References Cited (Backward Citations)
US2477598A
Cited
US3700215A
Cited
US4062524A
Cited
US4049241A
Cited
WO1983001210A1
Cited
EP0077752A2
Cited
EP0148116A1
Cited
DE3501331A1
Cited
DE3520772A1
Cited
US4743229A
Cited
US4753536A
Cited
WO1989008241A1
Cited
US4929088A
Cited
DE3838530A1
Cited
US4969747A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-06-19 | 1998-12-19 | 1999-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-06-19 | 2002-12-19 | 2003-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-06-19 | 2006-12-19 | 2007-06-20 | $7700.00 | Window Closed / Lapsed |