Autonomic nervous system testing by bi-variate spectral analysis of heart period and QT interval variability

Claim 3

A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

Claim 4

A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

Claim 5

A method for testing the autonomic nervous system of a mammal as set forth in claim 3, further comprising the step of calculating said terminal portion of said T wave through linear regression analysis.

Claim 6

A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating power spectral densities comprises the step of performing fast Fourier analysis on said calculated RR and QT intervals.

Claim 9

A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein said predetermined period of time comprises a 24 hour period, and said step of analyzing comprises the steps of outputting said electrical data signals in the form of circadian patterns and performing analysis of circadian variation of said calculated RR and QT intervals with respect to each other.

Claim 10

A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

Claim 11

A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

Claim 12

Apparatus for testing the autonomic nervous system of a mammal, comprising: means for obtaining electrocardiographic (ECG) data from said mammal under a selectable state of autonomic stimulation for a predetermined period of time; means for calculating heart period (RR) intervals and QT intervals for a predetermined number of heart beats represented in said ECG data, and for outputting the calculated RR and QT intervals in the form of electrical data signals; means for calculating power spectral densities of said RR and QT intervals; and means for analyzing the calculated RR and QT interval power spectral densities with respect to each other as an indication of the state of balance between parasympathetic and sympathetic controls of the autonomic nervous system of said mammal.

Claim 13

Apparatus for testing the autonomic nervous system of a mammal, comprising: means for obtaining electrocardiographic (ECG) data from said mammal under a selectable state of autonomic stimulation for a predetermined period of time; means for calculating heart period (RR) intervals and QT intervals for a predetermined number of heart beats represented in said ECG data, and for outputting the calculated RR and QT intervals in the form of electrical data signals; means for calculating power spectral densities of said RR and QT intervals; and means for analyzing the calculated RR and QT interval power spectral densities with respect to each other as an indication of the state of balance between parasympathetic and sympathetic controls of the autonomic nervous system of said mammal.

Claim 14

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating RR and QT intervals measures QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

Claim 15

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating RR and QT intervals measures QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

Claim 16

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 12, further comprising means for calculating said terminal portion of said T wave through linear regression analysis.

Claim 17

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating power spectral densities comprises means for performing fast Fourier analysis on said calculated RR and QT intervals.

Claim 18

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for obtaining electrocardiographic (ECG) data comprises a magnetic tape recorder/player.

Claim 19

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for obtaining electrocardiographic (ECG) data comprises a 24 hour ambulatory ECG recorder.

Claim 20

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating heart period (RR) intervals and QT intervals comprises a waveform analyzer.

Claim 21

Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating power spectral densities of said RR and QT intervals comprises a programmed personal computer.