US5418252A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for inhibiting cartilage degradation
Assignee: Eli Lilly and Co
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Filing: 1993-10-15
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Granted: 1995-05-23
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Expires: 2013-10-15
Abstract
Abstract A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula <IMAGE> (I) wherein R1 and R3 are independently hydrogen, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof.
Inventors
- 👤 Daniel C. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K31/381; A61K31/395; A61K31/40; A61K31/4025; A61K31/435; A61K31/44; A61K31/445; A61K31/4523; A61K31/4535; A61P; A61P43/00; C; C07; C07D; C07D409/00; C07D409/02; C07D409/10
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
64 words
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR5## wherein R 1 and R 3 are independently hydrogen, ##STR6## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
Claim 2
Independent Claim
64 words
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR5## wherein R 1 and R 3 are independently hydrogen, ##STR6## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
Claim 3
Dependent Claim
13 words
The method of Claim 1 wherein said compound is the hydrochloride salt thereof.
Claim 4
Dependent Claim
14 words
The method of Claim 1 wherein said compound is ##STR7## or its hydrochloride salt.
References Cited (Backward Citations)
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Cited
US4380635A
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Cited
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Cited
WO1993010113A1
Cited
WO1993010741A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-05-22 | 1998-11-21 | 1999-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-22 | 2002-11-21 | 2003-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-22 | 2006-11-21 | 2007-05-23 | $7700.00 | Window Closed / Lapsed |