US5411479A — Cancer treatment and catheter for use in treatment

Claim 1

Independent Claim 177 words

Apparatus for isolation and treatment of a portion of the body comprising a first catheter adapted for percutaneous insertion into a vein or artery, comprising (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood and (2) a second catheter for returning blood removed through said main lumen to the patient.

Claim 2

Dependent Claim 177 words

Apparatus for isolation and treatment of a portion of the body comprising a first catheter adapted for percutaneous insertion into a vein or artery, comprising (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood and (2) a second catheter for returning blood removed through said main lumen to the patient.

Claim 3

Dependent Claim 19 words

The apparatus of claim 1 wherein said cranial end is tapered to a diameter of an angiographic guide wire.

Claim 4

Dependent Claim 20 words

The apparatus of claim 2 wherein said plastic tube has a fourth lumen adapted to accommodate an angiographic guide wire.

Claim 5

Dependent Claim 21 words

The apparatus of claim 1 wherein said second and third lumina connect and are common to the interiors of said balloons.

Claim 6

Dependent Claim 19 words

The apparatus of claim 1 wherein said second and third lumina lie within the wall of said plastic tube.

Claim 7

Dependent Claim 168 words

A catheter adapted for percutaneous insertion into a vein or artery, comprising: a plastic tube having a cranial end and a caudal end and defining a main lumen for outflowing blood, caudal and cranial balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen, a second and third lumina within said plastic tube, said second lumina connecting to the balloon at said caudal end and said third lumina connecting to the cranial of balloon at the cranial end for effecting inflation or deflation of said balloons, the cranial end of said plastic tube is adapted to carry a smaller return catheter and said cranial end tapers to fit about said return catheter.

Claim 8

Dependent Claim 168 words

A catheter adapted for percutaneous insertion into a vein or artery, comprising: a plastic tube having a cranial end and a caudal end and defining a main lumen for outflowing blood, caudal and cranial balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube, and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen, a second and third lumina within said plastic tube, said second lumina connecting to the balloon at said caudal end and said third lumina connecting to the cranial of balloon at the cranial end for effecting inflation or deflation of said balloons, the cranial end of said plastic tube is adapted to carry a smaller return catheter and said cranial end tapers to fit about said return catheter.

Claim 9

Dependent Claim 18 words

The apparatus of claim 1 wherein said plastic tube contains an additional lumen adapted to monitor blood pressure.

Claim 10

Dependent Claim 36 words

The apparatus of claim 1 wherein the length of said plastic tube obtaining said fenestrations is in the range of nine to ten centimeters and said plastic tube has a maximum outside diameter of 24 French.

Claim 11

Dependent Claim 32 words

An apparatus of claim 1 wherein said caudal end extends through the skin of the patient to the outside of the body and terminates in a Luer fitting and a shut-off valve.

Claim 12

Dependent Claim 46 words

The apparatus of claim 1 wherein said balloons are spaced apart to isolate effluent blood from the hepatic veins when said catheter is inserted in the inferior vena cava and said fenestrations are sufficient to remove blood issuing from said hepatic veins without elevating blood pressure.

Claim 13

Dependent Claim 206 words

A kit for removing a treating agent from blood perfused through a body organ of a patient, comprising: a first catheter for isolating and removing the blood issuing from said body organ and containing said treating agent; a detoxification means for treating said blood so removed to remove said treating agent; and a second catheter for returning the blood so treated to said patient; said first catheter comprising: a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood.

Claim 14

Dependent Claim 206 words

A kit for removing a treating agent from blood perfused through a body organ of a patient, comprising: a first catheter for isolating and removing the blood issuing from said body organ and containing said treating agent; a detoxification means for treating said blood so removed to remove said treating agent; and a second catheter for returning the blood so treated to said patient; said first catheter comprising: a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood.

Claim 15

Dependent Claim 23 words

The kit of claim 11 wherein the detoxification means includes a treatment selected from the group consisting of hemoperfusion, hemodialysis, hemofiltration and hemoabsorption.

Claim 16

Dependent Claim 53 words

The kit of claim 11 wherein said second catheter fits within said plastic tube and said cranial end tapers to fit thereabout such that the treated blood is returned past the cranial balloon and said kit includes arterial injection means for introducing said treating agent into an artery leading to said body organ.

Claim 17

Dependent Claim 20 words

The kit of claim 11 wherein said body organ is the liver and said treating agent is an anti-cancer agent.

Claim 18

Dependent Claim 26 words

The kit of claim 11 including, in addition, an angiographic guide wire and said cranial end is tapered to a diameter of an angiographic guide wire.

Claim 19

Dependent Claim 202 words

A process for removing a treating agent from blood perfused through a body organ of a patient comprising: isolating blood issuing from said body organ with a catheter; removing said blood containing said treating agent from said patient through said catheter; detoxifying the blood so removed to remove said treating agent; and returning the blood so detoxified to the patient; said catheter comprising: a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to the one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood.

Claim 20

Dependent Claim 202 words

A process for removing a treating agent from blood perfused through a body organ of a patient comprising: isolating blood issuing from said body organ with a catheter; removing said blood containing said treating agent from said patient through said catheter; detoxifying the blood so removed to remove said treating agent; and returning the blood so detoxified to the patient; said catheter comprising: a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end of said plastic tube and said balloons, when inflated, having a size sufficient to block the flow of blood in a vein into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen and second and third lumina within said plastic tube, said second lumen connecting to the one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons, said cranial end of said plastic tube being closed to any appreciable inflow of blood.

Claim 21

Dependent Claim 32 words

The process of claim 16 wherein said treating agent is an anti-cancer agent and said blood is returned to the superior vena cava, subclavian or jugular vein or to the right atrium.

Claim 22

Dependent Claim 169 words

A catheter adapted for percutaneous insertion into a vein or artery, comprising: a plastic tube having a cranial end and defining a main lumen for outflowing blood; two balloons fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, said balloons when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons and a return lumen within said main lumen and extending to said cranial end, said cranial end sealing thereabout to prevent blood inflow from said cranial end into said main lumen, said return lumen discharging into the vein or artery beyond said cranial end.

Claim 23

Dependent Claim 169 words

A catheter adapted for percutaneous insertion into a vein or artery, comprising: a plastic tube having a cranial end and defining a main lumen for outflowing blood; two balloons fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end, said balloons when inflated, having a size sufficient to block the flow of blood in a vein or artery into which said catheter is designed to be inserted; fenestrations in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube, said second lumen connecting to one of said balloons and said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons and a return lumen within said main lumen and extending to said cranial end, said cranial end sealing thereabout to prevent blood inflow from said cranial end into said main lumen, said return lumen discharging into the vein or artery beyond said cranial end.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-05-01	1998-10-31	1999-05-02	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-05-01	2002-10-31	2003-05-02	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-05-01	2006-10-31	2007-05-02	$7700.00	Window Closed / Lapsed

Cancer treatment and catheter for use in treatment

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