US5405369A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Photochemical ablation of gastro-intestinal tissue for augmentation of an organ
Assignee: University of Toledo Medical Center
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Filing: 1994-01-25
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Granted: 1995-04-11
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Expires: 2014-01-25
Abstract
Abstract The present invention provides a method for treating a human or animal patient amenable an organ augmentation with gastro-intestinal tissue which is, or will be surgically transplanted into the patient's organ. The gastro-intestinal tissue is sensitized with an effective amount of a photosensitive composition which accumulates in the gastro-intestinal tissue. The sensitized tissue is exposed to a source of electromagnetic radiation energy for a predetermined time, wavelength and intensity sufficient to cause cellular and/or mucosal tissue function of the sensitized tissue to diminish or cease.
Inventors
- 👤 Steven H. Selman
- 👤 Kenneth A. Kropp
- 👤 Gregory D. Haselhuhn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:50
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B17/00; A61N; A61N5/00; A61N5/06; A61N5/0601; A61N5/0613; A61N5/062; A61N5/0603; A61N2005/0609; A61N2005/061
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
90 words
A method for treating a human or animal patient amenable to an organ augmentation procedure, wherein gastro-intestinal tissue is surgically transplanted into the patient's organ, which method comprises sensitizing the gastro-intestinal tissue with an effective amount of a photosensitive composition which accumulates in the gastro-intestinal tissue and exposing the gastro-intestinal tissue to a source of electromagnetic radiation energy for a predetermined period of time and at a predetermined wavelength and intensity, whereby the photosensitive composition accumulated in the irradiated-exposed gastro-intestinal tissue absorbs the electromagnetic radiation or undergoes a photochemical reaction.
Claim 2
Independent Claim
90 words
A method for treating a human or animal patient amenable to an organ augmentation procedure, wherein gastro-intestinal tissue is surgically transplanted into the patient's organ, which method comprises sensitizing the gastro-intestinal tissue with an effective amount of a photosensitive composition which accumulates in the gastro-intestinal tissue and exposing the gastro-intestinal tissue to a source of electromagnetic radiation energy for a predetermined period of time and at a predetermined wavelength and intensity, whereby the photosensitive composition accumulated in the irradiated-exposed gastro-intestinal tissue absorbs the electromagnetic radiation or undergoes a photochemical reaction.
Claim 3
Dependent Claim
26 words
The method of claim 1, in which the electromagnetic radiation energy causes cellular and/or mucosal tissue function of the transplant intestinal tissue to diminish or cease.
Claim 4
Dependent Claim
28 words
The method of claim 1, in which the gastro-intestinal tissue is sensitized with the photosensitive composition prior to the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 5
Dependent Claim
27 words
The method of claim 1, in which the gastro-intestinal tissue is sensitized with the photosensitive composition during the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 6
Dependent Claim
27 words
The method of claim 1, in which the gastro-intestinal tissue is sensitized with the photosensitive composition after the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 7
Dependent Claim
17 words
The method of claim 1, in which the organ receiving the gastro-intestinal tissue is the patient's bladder.
Claim 8
Dependent Claim
20 words
The method of claim 1, in which the electromagnetic radiation energy comprises ultraviolet light, visible light, infrared light or ultrasound.
Claim 9
Dependent Claim
27 words
The method of claim 1, in which the gastro-intestinal tissue is sensitized by administering the photosensitive composition to the patient by injection, topical, oral or suppository administration.
Claim 10
Dependent Claim
26 words
The method of claim 1, in which the photosensitive composition is administered to the patient in an amount of about 0.05-10.0 mg/kg of the patient's weight.
Claim 11
Dependent Claim
39 words
The method of claim 1, in which an electromagnetic delivery means having a directional distal end is positioned adjacent or within the patient's sensitized gastro-intestinal tissue prior for delivery of the electromagnetic radiation energy to the sensitized gastro-intestinal tissue.
Claim 12
Dependent Claim
21 words
The method of claim 1, wherein the electromagnetic radiation delivery means comprises an optical fiber which directs light within defined boundaries.
Claim 13
Dependent Claim
19 words
The method of claim 1, wherein the electromagnetic radiation delivery means comprises an optical fiber which radially diffuses light.
Claim 14
Dependent Claim
15 words
The method of claim 1, which further includes treating the sensitized tissue with hyperthermic therapy.
Claim 15
Dependent Claim
20 words
The method of claim 1, in which the photosensitive composition comprises photofrin, protoporphyrin-IX, tin ethyl etiopurpurin dichloride or hematoporphyrin derivative.
Claim 16
Independent Claim
215 words
A method of treating a patient who will have, is having or has had an organ augmentation with gastro-intestinal tissue comprising the steps of: (a) providing an apparatus for diagnosing or treating tissue comprising: a catheter for insertion into the patient's organ, the catheter having a proximal end and a distal end; the catheter comprising at least one axially extending opening therethrough for receiving an electromagnetic radiation delivery means; the delivery means having a transparent or translucent distal end and an opaque and/or reflective proximal end; the delivery means being operatively connected to a source of energy for delivery of electromagnetic radiation to the distal end of the delivery means; b) determining the position of the delivery means relative to the gasto-intestinal tissue and surrounding tissue of the patient to ensure that the distal end of the delivery means is adjacent the gastro-intestinal tissue; c) administering to the patient an effective amount of a photosensitive composition at a point in time prior to or during irradiation of the gastro-intestinal tissue; and d) irradiating the gastro-intestinal tissue by delivering electromagnetic radiation energy through the distal end of the delivery means to the gastro-intestinal tissue; the energy being delivered for a predetermined time and at a predetermined wavelength and intensity sufficient to effectively treat the gastro-intestinal tissue.
Claim 17
Independent Claim
215 words
A method of treating a patient who will have, is having or has had an organ augmentation with gastro-intestinal tissue comprising the steps of: (a) providing an apparatus for diagnosing or treating tissue comprising: a catheter for insertion into the patient's organ, the catheter having a proximal end and a distal end; the catheter comprising at least one axially extending opening therethrough for receiving an electromagnetic radiation delivery means; the delivery means having a transparent or translucent distal end and an opaque and/or reflective proximal end; the delivery means being operatively connected to a source of energy for delivery of electromagnetic radiation to the distal end of the delivery means; b) determining the position of the delivery means relative to the gasto-intestinal tissue and surrounding tissue of the patient to ensure that the distal end of the delivery means is adjacent the gastro-intestinal tissue; c) administering to the patient an effective amount of a photosensitive composition at a point in time prior to or during irradiation of the gastro-intestinal tissue; and d) irradiating the gastro-intestinal tissue by delivering electromagnetic radiation energy through the distal end of the delivery means to the gastro-intestinal tissue; the energy being delivered for a predetermined time and at a predetermined wavelength and intensity sufficient to effectively treat the gastro-intestinal tissue.
Claim 18
Dependent Claim
26 words
The method of claim 15, in which the electromagnetic radiation energy causes cellular and/or mucosal tissue function of the transplant intestinal tissue to diminish or cease.
Claim 19
Dependent Claim
28 words
The method of claim 15, in which the gastro-intestinal tissue is sensitized with the photosensitive composition prior to the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 20
Dependent Claim
27 words
The method of claim 15, in which the gastro-intestinal tissue is sensitized with the photosensitive composition during the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 21
Dependent Claim
27 words
The method of claim 15, in which the gastro-intestinal tissue is sensitized with the photosensitive composition after the transplantation of the gastro-intestinal tissue into the patient's organ.
Claim 22
Dependent Claim
17 words
The method of claim 15, in which the organ receiving the gastro-intestinal tissue is the patient's bladder.
Claim 23
Dependent Claim
20 words
The method of claim 15, in which the electromagnetic radiation energy comprises ultraviolet light, visible light, infrared light or ultrasound.
Claim 24
Dependent Claim
27 words
The method of claim 15, in which the gastro-intestinal tissue is sensitized by administering the photosensitive composition to the patient by injection, topical, oral or suppository administration.
Claim 25
Dependent Claim
26 words
The method of claim 15, in which the photosensitive composition is administered to the patient in an amount of about 0.05-10.0 mg/kg of the patient's weight.
Claim 26
Dependent Claim
21 words
The method of claim 15, wherein the electromagnetic radiation delivery means comprises an optical fiber which directs light within defined boundaries.
Claim 27
Dependent Claim
19 words
The method of claim 15, wherein the electromagnetic radiation delivery means comprises an optical fiber which radially diffuses light.
Claim 28
Dependent Claim
15 words
The method of claim 15, which further includes treating the sensitized tissue with hyperthermic therapy.
Claim 29
Dependent Claim
20 words
The method of claim 15, in which the photosensitive composition comprises photofrin, protoporphyrin-IX, tin ethyl etiopurpurin dichloride or hematoporphyrin derivative.
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| 7.5 Years (Year 8) | 2002-04-10 | 2002-10-10 | 2003-04-11 | $3760.00 | Window Closed / Lapsed |
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