US5401759A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nimodipine enhanced growth and vascularization of neural grafts
Assignee: Bayer Healthcare LLC
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Filing: 1992-06-03
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Granted: 1995-03-28
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Expires: 2012-06-03
Abstract
Abstract The invention relates to a method of enhancing vascularization and growth of neural grafts in warm-blooded animals, especially man, comprising administering an effective amount of the nimodipine, a calcium channel blocker, having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester) to the animals to achieve such enhancement and growth. The method enhances the survival rate of transplantations.
Inventors
- 👤 Stephen B. Dunnett
- 👤 Stanley Finger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 00:15
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
30 words
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising administering an effective amount of nimodipine to said animal to achieve such enhancement and growth.
Claim 2
Independent Claim
30 words
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising administering an effective amount of nimodipine to said animal to achieve such enhancement and growth.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein nimodipine has the formula: 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester).
Claim 4
Dependent Claim
34 words
The method of claim 2 in which the active compound is administered to deliver an effective amount of about 0.1 to 5.0 milligrams per kilogram body weight per day for greater than six days.
Claim 5
Dependent Claim
28 words
The method of claim 3 wherein the effective amount is about 5.0 milligrams per kilogram body weight per day which is administered for at least fourteen (14) days.
Claim 6
Dependent Claim
25 words
The method of claim 4 in which an oral dosage of from about 20 milligrams to about 80 milligrams is administered, four times per day.
Claim 7
Independent Claim
36 words
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester) prior to transplantation.
Claim 8
Independent Claim
36 words
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester) prior to transplantation.
Claim 9
Dependent Claim
24 words
The method of claim 6 in which the effective amount of nimodipine is from about 10.0 to about 15.0 milligrams per kilogram of tissue.
Claim 10
Independent Claim
32 words
A method of enhancing the viability of neural graft tissue, comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester) prior to transplantation.
Claim 11
Independent Claim
32 words
A method of enhancing the viability of neural graft tissue, comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl-pyridine-3-(β-methoxyethyl ester)-5-(isopropyl ester) prior to transplantation.
Claim 12
Dependent Claim
12 words
The method of claim 1 in which the warm-blooded animal is man.
Claim 13
Dependent Claim
12 words
The method of claim 6 in which the warm-blooded animal is man.
References Cited (Backward Citations)
US4406906A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-03-27 | 1998-09-26 | 1999-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-27 | 2002-09-26 | 2003-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-27 | 2006-09-26 | 2007-03-28 | $7700.00 | Window Closed / Lapsed |