Patent US2387751A successfully refreshed from Google Patents.
US5397902A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus and method for the preparation of a radiopharmaceutical formulation
Assignee: Lantheus Medical Imaging Inc
•
Filing: 1993-12-15
•
Granted: 1995-03-14
•
Expires: 2013-12-15
Abstract
Abstract Apparatus and method for producing a radiopharmaceutical formulation utilize a radiation-shielding container for receiving a vial having the non-radioactive components necessary to form a radiopharmaceutical formulation therein. A mixture of such non-radioactive components and a radioactive liquid added thereto is both heated and cooled using a thermoelectric element. The container comprises a hollow outer shielding member formed from a radiation shielding material and a vial holder formed from a highly heat conductive material received therewithin. The vial holder includes a skirt portion that defines a socket. The socket is sized to receive in an intimate heat transmissive relationship a mounting projection that is itself connected in thermally conductive contact with the thermoelectric element. Using the thermoelectric heating and cooling element, heat is both applied to and removed from the radioactive liquid and the non-radioactive components within the vial while the vial is held within the vial holder within the radiation shielding container, thereby to produce a radiopharmaceutical formulation within the vial.
Inventors
- 👤 James F. Castner
- 👤 Bobby E. Corry
- 👤 Thomas D. Harris
- 👤 Richard J. Looby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 02:53
CPC Classifications
G; G21; G21F; G21F5/00; G21F5/015; A; A61; A61J; A61J1/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
96 words
A radiation-shielding container for receiving a vial having the components necessary to form a radiopharmaceutical formulation contained therein and in which those components may be both heated and cooled, the container comprising: a hollow outer shielding member formed from a radiation shielding material; and a vial holder received within and substantially surrounded by the hollow outer shielding member, the vial holder being fabricated from a material having a high heat conductivity, the vial holder including a skirt portion that defines a socket, the socket being sized to receive a mounting projection in a heat transmissive relationship.
Claim 2
Dependent Claim
96 words
A radiation-shielding container for receiving a vial having the components necessary to form a radiopharmaceutical formulation contained therein and in which those components may be both heated and cooled, the container comprising: a hollow outer shielding member formed from a radiation shielding material; and a vial holder received within and substantially surrounded by the hollow outer shielding member, the vial holder being fabricated from a material having a high heat conductivity, the vial holder including a skirt portion that defines a socket, the socket being sized to receive a mounting projection in a heat transmissive relationship.
Claim 3
Dependent Claim
21 words
The radiation-shielding container of claim 1 further comprising a plug formed of a radiation shielding material disposed within the skirt portion.
Claim 4
Independent Claim
136 words
An apparatus in which the components necessary to form a radiopharmaceutical formulation contained within a vial are both heated and cooled, the apparatus comprising: a thermoelectric heating and cooling element; a mounting block having a mounting projection thereon, the block being connected in thermal conductive contact with the thermoelectric heating and cooling element, a radiation-shielding container for receiving a vial having the components of a radiopharmaceutical formulation contained therein, the container itself comprising: a hollow outer shielding member formed from a radiation shielding material, a vial holder received within and substantially surrounded by the hollow outer shielding member, the vial holder being fabricated from a material having a high heat conductivity, the vial holder including a skirt portion that defines a socket, the socket being sized to receive a mounting projection in a heat transmissive relationship.
Claim 5
Independent Claim
136 words
An apparatus in which the components necessary to form a radiopharmaceutical formulation contained within a vial are both heated and cooled, the apparatus comprising: a thermoelectric heating and cooling element; a mounting block having a mounting projection thereon, the block being connected in thermal conductive contact with the thermoelectric heating and cooling element, a radiation-shielding container for receiving a vial having the components of a radiopharmaceutical formulation contained therein, the container itself comprising: a hollow outer shielding member formed from a radiation shielding material, a vial holder received within and substantially surrounded by the hollow outer shielding member, the vial holder being fabricated from a material having a high heat conductivity, the vial holder including a skirt portion that defines a socket, the socket being sized to receive a mounting projection in a heat transmissive relationship.
Claim 6
Dependent Claim
20 words
The apparatus of claim 3 further comprising a plug formed of a radiation shielding material disposed within the skirt portion.
Claim 7
Independent Claim
200 words
A method for preparing a radiopharmaceutical formulation within a vial, the method comprising the steps of: a) inserting into a vial holder a vial having non-radioactive components necessary to form a radiopharmaceutical formulation, the vial holder being itself disposed within and substantially surrounded by a radiation-shielding container, the vial holder being fabricated from a material having a high thermal conductivity and including a skirt portion that defines a socket; b) adding a radioactive liquid to the non-radioactive components in the vial; c) disposing the vial holder in a heat transmissive relationship with a mounting projection on a mounting block by mounting the skirt portion of the vial holder onto the projection such that the projection extends into and is in heat transmissive relationship with the skirt portion of the vial holder, the mounting block being itself in thermal conductive contact with a thermoelectric heating and cooling element; and d) using the thermoelectric heating and cooling element, both applying heat to and removing heat from the mixture of the radioactive liquid and the non-radioactive components within the vial while the vial is held within the vial holder within the radiation shielding container, thereby to produce a radiopharmaceutical formulation within the vial.
Claim 8
Independent Claim
200 words
A method for preparing a radiopharmaceutical formulation within a vial, the method comprising the steps of: a) inserting into a vial holder a vial having non-radioactive components necessary to form a radiopharmaceutical formulation, the vial holder being itself disposed within and substantially surrounded by a radiation-shielding container, the vial holder being fabricated from a material having a high thermal conductivity and including a skirt portion that defines a socket; b) adding a radioactive liquid to the non-radioactive components in the vial; c) disposing the vial holder in a heat transmissive relationship with a mounting projection on a mounting block by mounting the skirt portion of the vial holder onto the projection such that the projection extends into and is in heat transmissive relationship with the skirt portion of the vial holder, the mounting block being itself in thermal conductive contact with a thermoelectric heating and cooling element; and d) using the thermoelectric heating and cooling element, both applying heat to and removing heat from the mixture of the radioactive liquid and the non-radioactive components within the vial while the vial is held within the vial holder within the radiation shielding container, thereby to produce a radiopharmaceutical formulation within the vial.
References Cited (Backward Citations)
US3531644A
Cited
US3655985A
Cited
GB1323873A
Cited
US3673411A
Cited
US3727059A
Cited
US3811591A
Cited
US4020355A
Cited
US3882315A
Cited
US3912935A
Cited
US3971955A
Cited
US4074824A
Cited
US4081688A
Cited
US4084097A
Cited
US4382512A
Cited
US4435358A
Cited
US4894550A
Cited
FR2540663A1
Cited
US4673813A
Cited
EP0211528A1
Cited
US4806098A
Cited
US4788438A
Cited
US5039863A
Cited
JPH02186300A
Cited
US5109160A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-13 | 1998-09-12 | 1999-03-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-13 | 2002-09-12 | 2003-03-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-13 | 2006-09-12 | 2007-03-14 | $7700.00 | Window Closed / Lapsed |