Triazolopyridazine compounds, their production and use

Claim 1

A compound of the formula: ##STR30## wherein R 1 stands for (i) a hydrogen atom, (ii) a C 1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxy, amino, carboxyl, nitro, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen or (iii) a halogen atom; R 2 and R 3 independently stand for stand for a hydrogen atom or a C 1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxy, amino, carboxyl, nitro, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen; X stands for an oxygen atom or S(O) p , wherein p is a whole number of from 0 to 2; Y stands for (i) a group of the formula: ##STR31## wherein R 4 and R 5 independently stand for a hydrogen atom or a C 1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxy, amino, carboxyl, nitro, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen or (ii) a divalent homocyclic or heterocyclic ring selected from the group consisting of ##STR32## which may be substituted with 1 to 5 substituents selected from the group consisting of a C 1-6 alkyl group which may be substituted with 1 to 4 substituents selected from the group consisting of hydroxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen, an amino group which may be substituted with 1 or 2 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 acyl, pyrrolidino, morpholino, piperidino and piperazino, a hydroxy, a carboxyl, a nitro, a C 1-6 alkoxy, and a halogen; R 6 and R 7 each stands for (i) a hydrogen, (ii) a C 1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxy, amino, carboxyl, amino, carboxyl, nitro, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen, (iii) a C 3-6 cycloalkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxy, amino, carboxyl, nitro, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkyl-carbonyloxy and halogen, (iv) a C 6-14 aryl group which may be substituted with one to five substituents selected from the group consisting of a C 1-6 alkyl which may be substituted with one to four substituents selected from the group consisting of hydroxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy and halogen, an amino which can be substituted with one or two substituents selected from the group consisting of C 1-6 alkyl, pyrrolidino, morpholino, piperidino and piperazino, an acetamido, a hydroxy, a carboxyl, a nitro, a C 1-6 alkoxy, a C 1-6 alkylcarbonyloxy and a halogen, or (v) R 6 and R 7 taken together with the adjacent nitrogen atom form a nitrogen-containing heterocyclic ring selected from the group consisting of ##STR33## which may be substituted with 1 to 5 substituents selected from the group consisting of a C 1-6 alkyl group which may be substituted with 1 to 4 substituents selected from the group consisting of hydroxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkoxy, C 1-6 alkylcarbonyloxy, and halogen, an amino group which may be substituted with 1 or 2 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 acyl, pyrrolidino, morpholino, piperidino and piperazino, a hydroxy, a carboxyl, a nitro, a C 1-6 alkoxy and a halogen; m stands for a whole number of from 0 to 4; n stands for a whole number of from 0 to 4; or a pharmaceutically acceptable salt thereof.