US5389611A
Expired / Lapsed
US
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Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent
Assignee: Morinaga Milk Industry Co Ltd
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Filing: 1991-12-09
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Granted: 1995-02-14
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Expires: 2011-12-09
Abstract
Abstract Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
Inventors
- 👤 Mamoru Tomita
- 👤 Kouzou Kawase
- 👤 Yoshitaka Tamura
- 👤 Mitsunori Takase
- 👤 Hiroshi Miyakawa
- 👤 Koji Yamauchi
- 👤 Hitoshi Saito
- 👤 Hiroaki Abe
- 👤 Seiichi Shimamura
- 👤 Susumu Kobayashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:50
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/005; A01; A01N; A01N63/00; A01N63/10; A23; A23B; A23B2/00; A23B2/70; A23B2/725; A23B2/729; A23B2/762; A23J; A23J3/00; A23J3/30; A23J3/32; A23J3/34; A23J3/341; A23J3/343; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/40; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61Q19/00; A61Q19/02; A61K2800/00; A61K2800/74; A61K2800/78; A61K2800/782
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
25 words
Lactoferrin hydrolyzate, obtained by hydrolyzing lactoferrin at a pH of from 1 to 4, such that said lactoferrin hydrolyzate has a decomposition rate of 6-20%.
Claim 2
Dependent Claim
25 words
Lactoferrin hydrolyzate, obtained by hydrolyzing lactoferrin at a pH of from 1 to 4, such that said lactoferrin hydrolyzate has a decomposition rate of 6-20%.
Claim 3
Dependent Claim
20 words
The lactoferrin hydrolyzate of claim 1, wherein said hydrolyzing is conducted at a temperature of from 80° to 130° C.
Claim 4
Dependent Claim
20 words
The lactoferrin hydrolyzate of claim 2, wherein said heating for a length of time of from 1 to 120 minutes.
Claim 5
Dependent Claim
12 words
The lactoferrin hydrolyzate of claim 1, having antibacterial and tyrosinase inhibition activities.
Claim 6
Dependent Claim
30 words
Lactoferrin hydrolyzate, obtained by enzymatically hydrolyzing lactoferrin with an acidic enzyme at a pH of from 1 to 4, such that said lactoferrin hydrolyzate has a decomposition rate of 6-20%.
Claim 7
Dependent Claim
30 words
Lactoferrin hydrolyzate, obtained by enzymatically hydrolyzing lactoferrin with an acidic enzyme at a pH of from 1 to 4, such that said lactoferrin hydrolyzate has a decomposition rate of 6-20%.
Claim 8
Dependent Claim
12 words
The lactoferrin hydrolyzate of claim 4, wherein said enzyme is swine pepsin.
Claim 9
Dependent Claim
19 words
The lactoferrin hydrolyzate of claim 4, wherein said hydrolyzing is conducted at a pH of from 2 to 3.
Claim 10
Dependent Claim
20 words
The lactoferrin hydrolyzate of claim 4, wherein said hydrolyzing is conducted at a temperature of from 15° to 55° C.
Claim 11
Dependent Claim
22 words
The lactoferrin hydrolyzate of claim 2, wherein said hydrolyzing is conducted for a length of time of from 30 to 600 minutes.
Claim 12
Dependent Claim
33 words
An antibacterial composition comprising the lactoferrin hydrolyzate of claim 1 in an excipient, medicine, cosmetic, food, feed or solution, said lactoferrin hydrolyzate being present in 25-1,000 parts per million,by weight of the composition.
Claim 13
Dependent Claim
34 words
An antibacterial composition comprising the lactoferrin hydrolyzate of claim 5 in an excipient, medicine, cosmetic, food, feed or solution, said lactoferrin hydrolyzate being present in 25-1,000 parts per million by weight of the composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-02-13 | 1998-08-15 | 1999-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-02-13 | 2002-08-15 | 2003-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-02-13 | 2006-08-15 | 2007-02-14 | $7700.00 | Window Closed / Lapsed |