US5389381A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin
Assignee: Sanofi SA
•
Filing: 1994-01-05
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Granted: 1995-02-14
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Expires: 2014-01-05
Abstract
Abstract Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.
Inventors
- 👤 Christopher P. Phillips
- 👤 Robert A. Snow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:44
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K38/00; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/69; A61K47/6949; A61K47/6951; C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/5406; C07K14/76; C07K14/77; C07K7/00; C07K7/04; C07K7/08; C07K7/083; C12; C12N; C12N9/00; C12N9/0004; C12N9/0065; C12N9/0089; C12N9/96; Y; Y02; Y02A; Y02A90/00; Y02A90/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
72 words
A method of treating a disease condition caused by superoxide anions on tissue in a mammal comprising administering an effective amount of a composition comprising from about 150 to about 150,000 units/ml of a covalently bound low diol polyethylene oxide superoxide dismutase: from about 0.1 to about 20% w/v of cyclodextrin: and from about 0.01 to about 50 nM buffer, said composition having a pH of from about 5.7 to about 6.5.
Claim 2
Independent Claim
72 words
A method of treating a disease condition caused by superoxide anions on tissue in a mammal comprising administering an effective amount of a composition comprising from about 150 to about 150,000 units/ml of a covalently bound low diol polyethylene oxide superoxide dismutase: from about 0.1 to about 20% w/v of cyclodextrin: and from about 0.01 to about 50 nM buffer, said composition having a pH of from about 5.7 to about 6.5.
Claim 3
Independent Claim
73 words
A method of treating a disease condition caused by superoxide anions on tissue in a mammal comprising administering an effective amount of a composition comprising: from about 150 to about 150,000 units/ml of a covalently bound low diol polyethylene oxide bovine superoxide dismutase: from about 0.1 to about 20% w/v of cyclodextrin; and from about 0.01 to about 50 nM buffer, said composition having a pH of from about 5,7 to about 6.5.
Claim 4
Independent Claim
73 words
A method of treating a disease condition caused by superoxide anions on tissue in a mammal comprising administering an effective amount of a composition comprising: from about 150 to about 150,000 units/ml of a covalently bound low diol polyethylene oxide bovine superoxide dismutase: from about 0.1 to about 20% w/v of cyclodextrin; and from about 0.01 to about 50 nM buffer, said composition having a pH of from about 5,7 to about 6.5.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said disease condition is inflammation.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein said disease condition is ischemia.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein said disease condition is reperfusion injury.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein said disease condition is trauma.
Claim 9
Dependent Claim
11 words
The method of claim 2 wherein said disease condition is inflammation.
Claim 10
Dependent Claim
11 words
The method of claim 2 wherein said disease condition is ischemia.
Claim 11
Dependent Claim
12 words
The method of claim 2 wherein said disease condition is reperfusion injury.
Claim 12
Dependent Claim
11 words
The method of claim 2 wherein said disease condition is trauma.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-02-13 | 1998-08-15 | 1999-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-02-13 | 2002-08-15 | 2003-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-02-13 | 2006-08-15 | 2007-02-14 | $7700.00 | Window Closed / Lapsed |