US5384316A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4,16-diazatetracyclo[23.3.1.1.Hu 14,17=b . 0 Hu 4,9 triaconta-16,19-diene-2,3,10-trione derivatives
Assignee: Fisons Ltd
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Filing: 1991-08-14
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Granted: 1995-01-24
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Expires: 2011-08-14
Abstract
Abstract Compounds of formula (I) are provided, wherein R 1 represents OH or OCH 3 ; R 2 represents OH or H; R 3 represents methyl, ethyl, propyl or allyl; X represents O, (H,OH) or (H,H); m represents 0 or 1; n represents 1 or 2; and pharmaceutically acceptable derivatives thereof; provided that when n is 1, then R 3 is allyl or propyl. The compounds are indicated inter alia as immunosuppresive agents. ##STR1##
Inventors
- 👤 David K. Donald
- 👤 Mark Furber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:32
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/22; A; A61; A61P; A61P37/00; A61P37/02; A61P37/06; C07H; C07H19/00; C07H19/01
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
64 words
A compound of formula I, ##STR5## wherein R 1 represents OH or OCH 3 ; R 2 represents OH or H; R 3 represents methyl, ethyl, propyl or allyl; X represents O, (H,OH) or (H,H); m represents 0 or 1; n represents 1 or 2; or a pharmaceutically acceptable derivative thereof; provided that when n is 1, then R 3 is allyl or propyl.
Claim 2
Dependent Claim
64 words
A compound of formula I, ##STR5## wherein R 1 represents OH or OCH 3 ; R 2 represents OH or H; R 3 represents methyl, ethyl, propyl or allyl; X represents O, (H,OH) or (H,H); m represents 0 or 1; n represents 1 or 2; or a pharmaceutically acceptable derivative thereof; provided that when n is 1, then R 3 is allyl or propyl.
Claim 3
Dependent Claim
13 words
A compound according to claim 1, wherein R 1 represents OCH 3 .
Claim 4
Dependent Claim
14 words
A compound according to claim 1 or claim 2, wherein R 2 represents OH.
Claim 5
Dependent Claim
13 words
A compound according to claim 1 or claim 2, wherein X represents 0.
Claim 6
Dependent Claim
13 words
A compound according to claim 1 or claim 2, wherein m represents 1.
Claim 7
Dependent Claim
30 words
A pharmaceutical composition comprising a compound of formula I, as defined in claim 1, or a pharmaceutically acceptable derivative thereof, in association with a pharmaceutically acceptable adjuvant, diluent or carrier.
Claim 8
Dependent Claim
32 words
A method of effecting immunosuppression which comprises administering a therapeutically effective amount of a compound of formula I, as defined in claim 1, or a pharmaceutically acceptable derivative thereof, to a patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-23 | 1998-07-25 | 1999-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-23 | 2002-07-25 | 2003-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-23 | 2006-07-25 | 2007-01-24 | $7700.00 | Window Closed / Lapsed |