US5378469A
Expired / Lapsed
US
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Collagen threads
Assignee: Organogenesis Inc
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Filing: 1991-10-07
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Granted: 1995-01-03
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Expires: 2011-10-07
Abstract
Abstract The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.
Inventors
- 👤 Paul D. Kemp
- 👤 Robert M. Carr, Jr.
- 👤 John G. Maresh
- 👤 John Cavallaro
- 👤 Jerome Gross
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/08; A61L27/14; A61L27/22; A61L27/24; A61L27/36; A61L27/38; A61L27/3804; A61L27/3808; A61L27/3813; A61L27/60; A61P; A61P43/00; D; D01; D01F; D01F4/00; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
58 words
A method of making thread comprising collagen, the method comprising: (a) extruding a solution comprising collagen into a dehydrating agent, the dehydrating agent having a higher osmotic pressure than that of the collagen solution and a pH from about 5 to 9; (b) maintaining the dehydrating agent under conditions to enable the extruded collagen to form a thread.
Claim 2
Independent Claim
58 words
A method of making thread comprising collagen, the method comprising: (a) extruding a solution comprising collagen into a dehydrating agent, the dehydrating agent having a higher osmotic pressure than that of the collagen solution and a pH from about 5 to 9; (b) maintaining the dehydrating agent under conditions to enable the extruded collagen to form a thread.
Claim 3
Dependent Claim
10 words
The method of claim 1, further comprising rinsing the thread.
Claim 4
Dependent Claim
21 words
The method of claim 2, wherein the thread is rinsed in a buffer having a pH of about 7 to 8.
Claim 5
Dependent Claim
14 words
The method of claim 2, further comprising drying the thread before and after rinsing.
Claim 6
Dependent Claim
14 words
The method of claim 1, further comprising forming native banded fibrils in the thread.
Claim 7
Dependent Claim
11 words
The method of claim 1, further comprising crosslinking the collagen thread.
Claim 8
Dependent Claim
19 words
The method of claim 1, further comprising rinsing the thread, drying the rinsed thread, and crosslinking the dried thread.
Claim 9
Dependent Claim
14 words
The method of claim 1, wherein the dehydrating agent comprises a water soluble polymer.
Claim 10
Dependent Claim
18 words
The method of claim 8, wherein the dehydrating agent comprises at least one of polyethylene glycol and dextran.
Claim 11
Dependent Claim
13 words
The method of claim 9, wherein the dehydrating agent further comprises phosphate buffer.
Claim 12
Dependent Claim
19 words
The method of claim 1, wherein the collagen solution is at a concentration of about 2 to 10 mg/ml.
Claim 13
Independent Claim
69 words
A method of making thread comprising collagen, the method comprising: (a) extruding a solution comprising collagen into a dehydrating agent having a higher osmotic pressure than that of the collagen solution and a pH from about 5 to 10; (b) maintaining the dehydrating agent under conditions to enable collagen thread formation; (c) rinsing the thread formed in step (b) in an aqueous buffer; and (d) crosslinking the collagen thread.
Claim 14
Independent Claim
69 words
A method of making thread comprising collagen, the method comprising: (a) extruding a solution comprising collagen into a dehydrating agent having a higher osmotic pressure than that of the collagen solution and a pH from about 5 to 10; (b) maintaining the dehydrating agent under conditions to enable collagen thread formation; (c) rinsing the thread formed in step (b) in an aqueous buffer; and (d) crosslinking the collagen thread.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-02 | 1998-07-04 | 1999-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-02 | 2002-07-04 | 2003-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-02 | 2006-07-04 | 2007-01-03 | $7700.00 | Window Closed / Lapsed |