US5373848A
Expired / Lapsed
US
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Ultrasonic time-domain method for sensing fluid flow
Assignee: HP Inc
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Filing: 1993-08-09
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Granted: 1994-12-20
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Expires: 2013-08-09
Abstract
Abstract Pulses of ultrasound are focused in the patient's body to create an interrogation volume where either the magnitude of velocity or the direction of blood flow is to be measured. The strength of the back-scattered signal is measured for each pulse and the mean squared rate of change of the envelope of the range-gated signal is estimated. In order to measure flow velocity independent of direction, the interrogation volume is generated substantially as a sphere by creating an ultrasonic wave envelope in which the components of the mean square spatial gradient are equal in all directions. The estimated mean square rate of change of the envelope of the back-scattered signal is then scaled to provide a direction-independent measurement of flow velocity. In order to determine the direction of flow, the interrogation volume is generated substantially as an ellipsoid. The long axis of the ellipsoidal interrogation volume is then rotated until the measured mean square rate of change of the envelope of the return signal is at a minimum, which is reached when the long axis is aligned with the flow direction. The interrogation volume is preferably rotated and translated using differential phasing of the ultrasonic signals from different transducer elements in a two-dimensional phased array.
Inventors
- 👤 Hewlett E. Melton, Jr.
- 👤 King-Wah W. Yeung
- 👤 Michael Greenstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:35
CPC Classifications
G; G01; G01S; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/8979; G01S15/8984; A; A61; A61B; A61B8/00; A61B8/06; G01S15/02; G01S15/50; G01S15/58; G01S15/582
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
164 words
A method for measuring blood flow within a blood vessel or organ comprising the following steps: A. repeatedly applying to each of a plurality of piezoelectric transducer elements a corresponding pulsed electrical transmit signal; B. in the transducer elements, sensing a receive signal that is back-scattered from blood within the blood vessel; C. electrically shaping and phasing the transmit and receive signals to generate an interrogation signal within an interrogation volume, within which blood flow is to be measured; D. for each application of the pulsed electrical excitation signals, sensing an ultrasonic return signal that is back-scattered from particles within the interrogation volume; E. converting the sensed ultrasonic return signals into a corresponding composite electrical return signal; F. calculating an estimate of a mean square rate of change in time of an envelope of the composite electrical return signal; and G. outputting a representation of a predetermined blood flow characteristic as a predetermined function of the estimated mean square rate of change in time.
Claim 2
Independent Claim
164 words
A method for measuring blood flow within a blood vessel or organ comprising the following steps: A. repeatedly applying to each of a plurality of piezoelectric transducer elements a corresponding pulsed electrical transmit signal; B. in the transducer elements, sensing a receive signal that is back-scattered from blood within the blood vessel; C. electrically shaping and phasing the transmit and receive signals to generate an interrogation signal within an interrogation volume, within which blood flow is to be measured; D. for each application of the pulsed electrical excitation signals, sensing an ultrasonic return signal that is back-scattered from particles within the interrogation volume; E. converting the sensed ultrasonic return signals into a corresponding composite electrical return signal; F. calculating an estimate of a mean square rate of change in time of an envelope of the composite electrical return signal; and G. outputting a representation of a predetermined blood flow characteristic as a predetermined function of the estimated mean square rate of change in time.
Claim 3
Dependent Claim
114 words
A method as defined in claim 1, in which the predetermined blood flow characteristic is the magnitude of flow velocity, comprising the following additional steps: A. shaping and phasing the electrical transmit and receive signals to the transducer elements so that the interrogation volume is substantially spherical and isotropic; and B. determining a proportionality factor equal to the mean square rate of change in space of the envelope of the return signal from the interrogation volume; in which the predetermined function of the estimated mean square rate of change in time used to calculate the magnitude of flow velocity comprises dividing the estimated mean square rate of change in time by the proportionality factor.
Claim 4
Dependent Claim
49 words
A method as defined in claim 2, in which the step of shaping and phasing the electrical transmit and receive signals includes generating the transmit and receive signals with mutual interference such that the mean square spatial gradient of the wave envelope is substantially constant within the interrogation volume.
Claim 5
Dependent Claim
40 words
A method as defined in claim 3, in which the step of shaping and phasing the electrical transmit and receive signals includes generating the interrogation volume with a range dimension substantially equal to an elevational dimension and an azimuthal dimension.
Claim 6
Dependent Claim
111 words
A method as defined in claim 1, in which the predetermined blood flow characteristic is the direction of blood flow, comprising the following additional steps: A. shaping and phasing the transmit and receive signals to the transducer elements so that the interrogation volume is substantially ellipsoidal with a long axis; B. generating a plurality of the ellipsoidal interrogation volumes with different directions of their respective long axes; and C. outputting as the representation of the flow direction the direction of the long axis of the ellipsoidal interrogation volume for which the estimated mean square rate of change in time of the envelope of the electrical return envelope signals is a minimum.
Claim 7
Dependent Claim
35 words
A method as defined in claim 5, in which the step of shaping and phasing the transmit and receive signals includes differential phasing of a plurality of transducer elements arranged as a two-dimensional phased array.
Claim 8
Independent Claim
229 words
A method for measuring the magnitude of velocity of blood flow in a blood vessle or organ comprising the following steps: A. repeatedly applying to each of a plurality of piezoelectric transducer elements a corresponding pulsed electrical excitation signal; B. in the transducer elements, sensing a receive signal that is back-scattered from blood within the blood vessel or organ; C. electrically shaping and phasing the transmit and receive signals to generate a substantially spherical and isotropic interrogation volume within which blood flow is to be measured, with the mean square gradient of a wave envelope of the interrogation volume substantially constant; D. for each application of the pulsed electrical excitation signals, sensing an ultrasonic return signal that is back-scattered from particles within the interrogation volume; E. converting each sensed ultrasonic return signal into a corresponding electrical return signal; F. calculating an estimate of a mean square rate of change in time of an envelope of the electrical return envelope signals; G. determining a proportionality factor equal to the mean square rate of change in space of a wave envelope of the interrogation volume; H. calculating an estimate of a mean square rate of change in time of the envelope of the return signals; and I. outputting a representation of the magnitude of blood flow velocity corresponding to the estimated mean square rate of change divided by the proportionality factor.
Claim 9
Independent Claim
229 words
A method for measuring the magnitude of velocity of blood flow in a blood vessle or organ comprising the following steps: A. repeatedly applying to each of a plurality of piezoelectric transducer elements a corresponding pulsed electrical excitation signal; B. in the transducer elements, sensing a receive signal that is back-scattered from blood within the blood vessel or organ; C. electrically shaping and phasing the transmit and receive signals to generate a substantially spherical and isotropic interrogation volume within which blood flow is to be measured, with the mean square gradient of a wave envelope of the interrogation volume substantially constant; D. for each application of the pulsed electrical excitation signals, sensing an ultrasonic return signal that is back-scattered from particles within the interrogation volume; E. converting each sensed ultrasonic return signal into a corresponding electrical return signal; F. calculating an estimate of a mean square rate of change in time of an envelope of the electrical return envelope signals; G. determining a proportionality factor equal to the mean square rate of change in space of a wave envelope of the interrogation volume; H. calculating an estimate of a mean square rate of change in time of the envelope of the return signals; and I. outputting a representation of the magnitude of blood flow velocity corresponding to the estimated mean square rate of change divided by the proportionality factor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-19 | 1998-06-20 | 1998-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-19 | 2002-06-20 | 2002-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-19 | 2006-06-20 | 2006-12-20 | $7700.00 | Window Closed / Lapsed |